4-Chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury

Journal of Neurotrauma

Volumn 23, Issue 6, 2006, Pages 866-881

  Yates, Jennifer R ^a,e   Heyes, Melvyn P ^b,c   Blight, Andrew R ^a,d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c PSYCHOGENICS INC   (United States)

^d ACORDA THERAPEUTICS INC   (United States)

^e Colby College   (United States)

Author keywords

Guinea pig; Inflammation; Kynurenine pathway; Macrophage; Neurotoxin; Spinal cord trauma

Indexed keywords

3 HYDROXYANTHRANILATE 3,4 DIOXYGENASE; 4 CHLORO 3 HYDROXYANTHRANILIC ACID; KYNURENIC ACID; NEUROTOXIN; QUINOLINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GUINEA PIG; IMMUNOREACTIVITY; INFLAMMATION; MACROPHAGE ACTIVATION; MICROGLIA; MOTOR PERFORMANCE; NERVE FIBER; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; TISSUE INJURY; WHITE MATTER;

3-HYDROXYANTHRANILIC ACID; ALGORITHMS; ANIMALS; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; FEMALE; GUINEA PIGS; KYNURENIC ACID; MYELIN SHEATH; PERMEABILITY; PROPRIOCEPTION; QUINOLINIC ACID; REFERENCE STANDARDS; REFLEX, MONOSYNAPTIC; SPINAL CORD COMPRESSION; SPINAL CORD INJURIES;

EID: 33745482548     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2006.23.866     Document Type: Article

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