Operant conditioning and the orbitofrontal cortex in schizophrenic patients: Unexpected evidence for intact functioning

Schizophrenia Research

Volumn 30, Issue 2, 1998, Pages 169-174

  Wilder, Kelly E ^a   Weinberger, Daniel R ^a   Goldberg, Terry E ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DECISION MAKING; FEMALE; HUMAN; INSTRUMENTAL CONDITIONING; LONG TERM MEMORY; MALE; ORBITAL CORTEX; PATHOLOGICAL GAMBLING; PRIORITY JOURNAL; REWARD; SCHIZOPHRENIA; WORKING MEMORY;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ATTENTION; CASE-CONTROL STUDIES; CONDITIONING, OPERANT; FEMALE; GAMBLING; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; PUNISHMENT; REWARD; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; VOLITION;

EID: 0032502344     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(97)00135-7     Document Type: Article

References (21)

1. Abbruzzese, M., Bellodi, L., Ferri, S., Scarone, S., 1995. Frontal lobe dysfunction in schizophrenia and obsessive compulsive disorder: a neuropsychological study. Brain Cognition 27, 202-212.
2. Bechara, A., Damasio, A.R., Damasio, H., Anderson, S.W., 1994. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15.
3. Deakin, J.F., Slater, P., Simpson, M.D., Royston, M.C., 1990. Hyperinnervation of orbital frontal cortex in schizophrenia. Br. J. Psychiatry 157, 459-460.
4. Doty, R.L., Shaman, P., Dann, M., 1984. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol. Behav. 12, 205-211.
5. Eslinger, P.J., Damasio, A.R., 1985. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 35, 1731-1741.
6. Faraone, S.V., Seidman, L.J., Oscar-Berman, L.J., Kreman, W.S., Toomey, R., Tsuang, M.T., 1997. Object alternation deficits in first-degree relatives of schizophrenic patients. Schiz. Res. 24, 45
7. Fuster, J.M., 1989. The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe, 2nd ed. New York, Raven Press.
8. Goldberg, T.E., Gold, J.M., 1996. Neurocognitive functioning in patients with schizophrenia. In Bloom, F.E., Kupfer, D.J. (Eds), Psychopharmacology: The Fourth Generation of Progress. New York, Raven Press, pp. 1245-1257
9. Greenberg, M.H., Weiner, B., 1966. Effects of reinforcement history upon risk taking behavior. J. Exp. Psychol. 71, 587-592.
10. Hasher, L., Zachs, R.T., 1984. Automatic processing of fundamental information. Am. Psychol. 39, 1372-1388.
11. Houlihan, D.J., Flaum, M., Arnold, S.E., Keshavan, M., Aliger, R., 1994. Further evidence for olfactory identification deficits in schizophrenia. Schiz. Res. 12. 179-182.
12. Hurwitz, T., Kopala, L., Clark, C., Jones, B., 1988. Olfactory deficits in schizophrenia. Biol. Psychiatry 23, 123-128.
13. Kopala, L.C., Good, K.P., Honer, W.G., 1994. Olfactory hallucinations and olfactory identification ability in patients with schizophrenia and other psychiatric disorders. Schiz. Res. 12, 205-211.
14. Malaspina, D., Wray, A., Harkavy Friendman, J., Amador, X., Yale, S., Hasam, A., Gorman, J., Kaufmann, C., 1994. Odor discrimination deficits in schizophreniz: association with eye movement dysfunction. J. Neuropsychiatry 6, 273-278.
15. Malloy, P., Bihrl, A., Duffy, J., Cimino, C., 1993. The orbitomedial frontal syndrone. Arch. Clin. Neuropsychol. 8, 185-201.
16. Miller, L., Meyer, D.E., Lanzetta, J.T., 1969. Choice among equal expected value alternatives: sequential effects of winning probability level on risk preferences. J. Exp. Psychol. 79. 419-423.
17. Schneider, J.W., 1973. Reinforcer effectiveness as a function of reinforcer rate and magnitude: a comparison of concurrent performances. J. Exp. Analysis Behav. 20, 461-471.
18. Seidman, L.J., Talbot, N.L., Kalinowski, A.G., McCarley, R.W., Faranoe, S.V., Dremen, W.S., Pepple, J.R., Tsuang, M.T., 1992. Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia: olfactory identification and Wisconsin Card sorting performance. Schiz. Res. 6, 55-65.
19. Steinhauer, G.D., 1984. Preference for predictable small rewards over unpredictable larger rewards. Psychol. Rep. 54, 467-471.
20. Wichmann, T., Vitek, J.L., DeLong, M.R., 1995. Parkinson' disease and the basal ganglia: lessons from the laboratory and from neurosurgery. Neuroscientist 1, 236-244.
21. Wu, J., Buchsbaum, M.S., Moy, K., Denlea, N., Kesslak, P., Tseng, H., Plosnaj, D., Potkin, S., Bracha, S., Cotman, C., 1993. Olfactory memory in unmedicated schizophrenics. Schiz. Res. 9, 41-47.