A variation of the translation attenuation model can explain the inducible regulation of the pBC16 tetracycline resistance gene in Bacillus subtilis

Journal of Bacteriology

Volumn 188, Issue 13, 2006, Pages 4749-4758

  Lodato, Patricia B ^a,b   Rogers, Elizabeth J ^a   Lovett, Paul S ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; MESSENGER RNA; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CAT GENE; ERM GENE; GENE EXPRESSION; GENE MUTATION; GRAM POSITIVE BACTERIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECONDARY STRUCTURE; REPRESSOR GENE; RIBOSOME; START CODON; STOP CODON; TET GENE; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BASE SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PLASMIDS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TETRACYCLINE; TETRACYCLINE RESISTANCE;

BACILLUS SUBTILIS; POSIBACTERIA;

EID: 33745465385     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01937-05     Document Type: Article

References (37)

1. Alexieva, Z., E. J. Duvall, N. P. Ambulos, Jr., U. J. Kim, and P. S. Lovett. 1988. Chloramphenicol induction of cat-86 requires ribosome stalling at a specific site in the leader. Proc. Natl. Acad. Sci. USA 85:3057-3061.
2. Ambulos, N. P., Jr., E. J. Duvall, and P. S. Lovett. 1987. Method for blot-hybridization analysis of mRNA molecules from Bacillus subtilis. Gene 51:279-284.
3. Ambulos, N. P., Jr., T. Smith, W. Mulbry, and P. S. Lovett. 1990. CUG as a mutant start codon for cat-86 and xylE in Bacillus subtilis. Gene 94:125-128.
4. Aoki, T., M. Kaneta, and H. Watabe. 1993. Detection of tetracycline resistance protein encoded by Bacillus subtilis plasmid pNS1. Biol. Pharm. Bull. 16:81-83.
5. Bechhofer, D. H., and D. Dubnau. 1987. Induced mRNA stability in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 84:498-502.
6. Bernhard, K., H. Schrempf, and W. Goebel. 1978. Bacteriocin and antibiotic resistance plasmids in Bacillus cereus and Bacillus subtilis. J. Bacteriol. 133:897-903.
7. Bradford, M. M. 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-252.
8. Brodersen, D. E., W. M. Clemons, Jr., A. P. Carter, R. J. Morgan-Warren, B. T. Wimberly, and V. Ramakrishnan. 2000. The structural basis for the action of the antibiotics tetracycline, pactamycin and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-1154.
9. Dreher, J., and H. Matzura. 1991. Chloramphenicol-induced stabilization of cat messenger RNA in Bacillus subtilis. Mol. Microbiol. 5:3025-3034.
10. Dubnau, D. 1984. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics. Crit. Rev. Biochem. 16:103-132.
11. Duvall, E. J., N. P. Ambulos, Jr., and P. S. Lovett. 1987. Drug-free induction of a chloramphenicol acetyltransferase gene in Bacillus subtilis by stalling ribosomes in a regulatory leader. J. Bacteriol. 169:4235-4241.
12. Duvall, E. J., and P. S. Lovett. 1986. Chloramphenicol induces translation of the mRNA for a chloramphenicol-resistance gene in Bacillus subtilis. Proc. Natl. Acad. Sci. USA 83:3939-3943.
13. Francia, M. V., and D. B. Clewell. 2002. Amplification of the tetracycline resistance determinant of pAMα1 in Enterococcus faecalis requires a site-specific recombination event involving relaxase. J. Bacteriol. 184:5187-5193.
14. Hansen, J. L., J. A. Ippolito, N. Ban, P. Nissen, P. B. Moore, and T. A. Steitz. 2002. The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol. Cell 10:117-128.
15. Hansen, J. L., P. B. Moore, and T. A. Steitz. 2003. Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J. Mol. Biol. 330:1061-1075.
16. R controls. Gene 37:131-138.
17. Khan, S. A., and R. P. Novick. 1983. Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus. Plasmid 10:251-259.
18. Lacks, S. A., P. Lopez, B. Greenberg, and M. Espinosa. 1986. Identification and analysis of genes for tetracycline resistance and replication functions in the broad-host-range plasmid pLS1. J. Mol. Biol. 192:753-765.
19. Lovett, P. S. 1990. Translational attenuation as the regulator of inducible cat genes. J. Bacteriol. 172:1-6.
20. Mayford, M., and B. Weisblum. 1989. Messenger RNA from Staphylococcus aureus that specifies macrolide-lincosamide-streptogramin resistance: demonstration of its conformation and of the leader it encodes. J. Mol. Biol. 185:765-780.
21. McMurry, L. M., and S. B. Levy. 2000. Tetracycline resistance in gram-positive bacteria, p. 660-677. In V. A. Fischetti, R. P. Novick, J. J. Ferreti, D. A. Portnoy, and J. I. Rood (ed.), Gram-positive pathogens. ASM Press, Washington, D.C.
22. Mongkolsuk, S., and P. S. Lovett. 1984. Selective expression of a plasmid cat gene at a late stage of Bacillus subtilis sporulation. Proc. Natl. Acad. Sci. USA 81:3457-3460.
23. Moscoso, M., G. del Solar, and M. Espinosa. 1995. In vitro recognition of the replication origin of pLS1 and of plasmids of the pLS1 family by the RepB initiator protein. J. Bacteriol. 177:7041-7049.
24. Palva, A., G. Vigren, M. Simonen, H. Rintala, and P. Laamanen. 1990. Nucleotide sequence of the tetracycline resistance gene of pBC16 from Bacillus cereus. Nucleic Acids Res. 18:1635.
25. Platteeuw, C., F. Michiels, H. Joos, J. Seurinck, and W. M. De Vos. 1995. Characterization and heterologous expression of the tet(L) gene and identification of iso-ISS1 elements from Enterococcus faecalis plasmid pJH1. Gene 160:89-93.
26. Polak, J., and R. P. Novick. 1982. Closely related plasmids from Staphylococcus and soil bacteria. Plasmid 7:152-162.
27. Sandler, P., and B. Weisblum. 1988. Erythromycin-induced stabilization of ermA messenger RNA in Staphylococcus aureus and Bacillus subtilis. J. Mol. Biol. 203:905-915.
28. Schwarz, S., M. Cardoso, and H. Wegener. 1992. Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus. Antimicrob. Agents Chemother. 36:580-588.
29. Selinger, L. B., N. F. McGregor, G. G. Khachatourians, and M. F. Hynes. 1990. Mobilization of closely related plasmids pUB110 and pBC16 by Bacillus plasmid pXO503 requires trans-acting open reading frame beta. J. Bacteriol. 172:3290-3297.
30. Stasinopoulos, S. J., G. A. Farr, and D. H. Bechhofer. 1998. Bacillus subtilis tetA(L) gene expression: evidence for regulation by translational reinitiation. Mol. Microbiol. 30:923-932.
31. Van Bambeke, F., Y. Glupczynski, P. Plesiat, J. C. Pechere, and P. M. Tulkens. 2003. Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy. J. Antimicrob. Chemother. 51:1055-1065.
32. Wei, Y., and D. H. Bechhofer. 2002. Tetracycline induces stabilization of mRNA in Bacillus subtilis. J. Bacteriol. 184:889-894.
33. Weisblum, B. 1983. Inducible resistance to macrolides, lincosamides, and streptogramin B type antibiotics: the resistance phenotype, its biological diversity, and structural elements that regulate expression, p. 91-121. In J. Beckwith, J. Davies, and J. A. Gallent (ed.), Gene function in procaryotes. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
34. Glu as indicated by different nuclease digestion patterns. J. Biol. Chem. 254:9608-9616.
35. Xayaphoummine, A., T. Bucher, F. Thalmann, and H. Isambert. 2003. Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations. Proc. Natl. Acad. Sci. USA 100:15310-15315.
36. Xayaphoujnmine, A., T. Bucher, and H. Isambert. 2005. Kinefold web server for RNA/DNA folding path and structure prediction including pseudoknots and knots. Nucleic Acids Res. 33:605-610.
37. Yin, C.-C., M. L. Aldema-Ramos, I. Borges-Walmsley, R. W. Taylor, A. R. Walmsley, S. B. Levy, and P. A. Bullough. 2000. The quaternary molecular architecture of TetA, a secondary tetracycline transporter from Escherichia coli. Mol. Microbiol. 38:482-492.