Oestrogen receptor genetics: A needle that cuts through many haystacks?

European Heart Journal

Volumn 27, Issue 13, 2006, Pages 1519-1520

  Shearman, Amanda M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA1; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; EDITORIAL; ENVIRONMENTAL FACTOR; ESR1 GENE; ESTROGEN ACTIVITY; GENE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENETIC RISK; GENOTYPE; HAPLOTYPE; HORMONE RECEPTOR INTERACTION; HUMAN; PRIORITY JOURNAL; RISK FACTOR;

CARDIOVASCULAR DISEASES; ESTROGEN RECEPTOR ALPHA; FEMALE; GENOTYPE; HUMANS; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 33745454694     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl065     Document Type: Editorial

References (16)

1. Lehtimaki T, Kunnas TA, Mattila KM, Perola M, Penttila A, Koivula T, Karhunen PJ. Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study. J Mol Med 2002;80:176-180.
2. Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Brosnihan KB, Meyers DA, Bleecker ER. Estrogen-receptor polymorphisms an d effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 2002;346:967-974.
3. Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA, Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 2002;105:1879-1882.
4. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003;290:2263-2270.
5. Koivu TA, Fan YM, Mattila KM, Dastidar P, Jokela H, Nikkari ST, Kunnas T, Punnonen R, Lehtimaki T. The effect of hormone replacement therapy on atherosclerotic severity in relation to ESR1 genotype in postmenopausal women. Maturitas 2003;44:29-38.
6. Schuit SC, Oei HH, Witteman JC, Geurts van Kessel CH, van Meurs JB, Nijhuis RL, van Leeuwen JP, de Jong FH, Zillikens MC, Hofman A, Pols HA, Uitterlinden AG. Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. JAMA 2004;291:2969-2677.
7. Lawlor DA, Timpson N, Ebrahim S, Day INM, Smith GD. The association of estrogen receptor α-haplotype with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J 2006;27:1597-1604. First published on March 21, 2006, doi:10.1093/eurheartj/ehi833.
8. Majewski J, Ott J. Distribution and characterization of regulatory elements in the human genome. Genome Res 2002;12:1827-1836.
9. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003;33:177-182.
10. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-loannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-309.
11. Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SCE, Uitterlinden AG, Pols HAP, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE. Estrogen receptor α gene variation is associated with risk of myocardial infarction in over 7000 men from 5 cohorts. Circ Res 2006;98:590-592.
12. Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ. Estrogen receptor α gene variation risk of stroke. Stroke 2005;36:2281-2282.
13. Lussana F, Faioni EM, Mavilia C, Bucciarelli P, Brandi ML, Cattaneo M. Association of estrogen receptor-alpha gene polymorphisms with venous thrombosis. Haematologica 2006;91:279-280.
14. Koch W, Hoppmann P, Pfeufer A, Mueller JC, Schomig A, Kastrati A. No replication of association between estrogen receptor alpha gene polymorphisms and susceptibility to myocardial infarction in a large sample of patients of European descent. Circulation 2005;112:2138-2142.
15. de Maat MP, Bladbjerg EM, Kluft C, Winkler UH, Rekers H, Skouby SO, Jespersen J. Estrogen receptor 1 haplotype does not regulate oral contraceptive-induced changes in haemostasis and inflammation risk factors for venous and arterial thrombosis. Hum Reprod 2006;21:1473-1476.
16. Ioannidis JPA, Ralston SH, Bennett ST, Brandi ML, Grinberg D, Karassa FB, Langdahl B, van Meurs JBJ, Mosekilde L, Scollen S, Albagha OME, Bustamante M, Carey AH, Dunning AM, Enjuanes A, van Leeuwen JPTM, Mavilia C, Masi L, McGuigan FEA, Nogues X, Pols HAP, Reid DM, Schuit SCE, Sherlock RE, Uitterlinden AG. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA 2004;292:2105-2144.