Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension

National Medical Journal of China

Volumn 86, Issue 16, 2006, Pages 1138-1143

  Zhang, Jing Qun ^a   Sun, Hong Lei ^a   Ma, Ye Xin ^a   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Hypertension, renovascular; Receptor, angiotensin

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; SHORT HAIRPIN RNA; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CLAMP; ARTICLE; BLOOD PRESSURE REGULATION; CAROTID ARTERY; CATHETERIZATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG TARGETING; GENE THERAPY; HEART HYPERTROPHY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART WEIGHT; HISTOPATHOLOGY; NONHUMAN; PLASMID; PROMOTER REGION; PROTEIN EXPRESSION; RAT; RAT STRAIN; RENAL ARTERY; RENOVASCULAR HYPERTENSION; RNA INTERFERENCE; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; TUNICA MEDIA; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; DISEASE MODELS, ANIMAL; GENE THERAPY; HYPERTENSION, RENOVASCULAR; MALE; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RNA INTERFERENCE; TREATMENT OUTCOME; VENTRICULAR REMODELING;

EID: 33745444212     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Galli SM, Phillips MI. Angiotensm II AT(1A) receptor antisense lowers blood pressure in acute 2-kidney, 1-clip hypertension. Hypertension,2001,38 (3 Pt 2):674-678.
2. Peng JF, Kimura B, Fregly NJ, et al. Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. Hypertension, 1998,31:1317-1323.
3. Phillips MI, Mohuczy-Dominiak D, Coffey M, et al. Prolonged reduction of high blood pressure with an in vivo, nonpathogenic, adeno-associated viral vector delivery of AT1-R mRNA antisense. Hypertension, 1997,29(1 Pt 2):374-80.
4. Elbashir SM, Harborth J, Lendeckel W, et al. (2001a). Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature,411: 494-498.
5. Chinese source. 2005,85:1601-1604.
6. Butticaz C, Ciuffi A, Munoz M, et al. Protection from HIV-1 infection of primary CD4 T cells by CCR5 silencing is effective for the full spectrum of CCR5 expression. Antivir Ther,2003,8:373-377.
7. Giladi H, Ketzinel-Gilad M, Rivkin L, et al. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther,2003,8:769-776.
8. Chinese source. 2005,85:630-634.
9. Ding H, Schwarz DS, Keene A, et al. Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell, 2003,2:209-217.
10. Brantl S. Antisense-RNA regulation and RNA interference. Biochimica Biophysics Acta, 2002,1575:15-25.
11. Shan ZZ, Dai SM, Chen H, et al. Hypertension-associated left ventricular hypertrophy is related to the expression of cardiac proto-oncogene c-fos. Chinese J Pharmacol toxicolo,1998,12:161-165.
12. Elbashir SM, Martinez J, Patkaniowska A, et al. (2001c). Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J, 20: 6877-6888.
13. Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs Exhibit Strand Bias. Cell,2003, 115:209-216.
14. Reynolds A, Leake D, Boese Q, et al. Rational siRNA design for RNA interference. Nat Biotechnol,2004,22:326-330.
15. de Gasparo M, Catt KJ, Inagami T, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev, 2000,52:415-472.
16. Goldblatt H, Lynch J, Hanzal RF, et al. Studies on experimental hypertension: production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med, 1934,59:347-379.
17. Wiesel P, Mazzolai L, Nussberger J, et al. Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension, 1997,29:1025-1030.
18. Cervenka L, Vladislav Horacek V, Vaneckova I, et al. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension, 2002,40:735-741.
19. Hannon GJ. RNA interference. Nature, 2002,418:244-251.