Identification of human platelet glycoprotein VI-specific IgG autoantibody and its fragments

Blood Coagulation and Fibrinolysis

Volumn 17, Issue 5, 2006, Pages 403-407

  Chu, Xiaoxia ^a   Hou, Ming ^a   Peng, Jun ^a   Zhu, Yuanyuan ^a   Zhang, Feng ^a   Ji, Xuebin ^a   Wang, Lin ^a   Ma, Daoxin ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Glycoprotein VI; Idiopathic thrombocytopenic purpura; Platelet aggregation

Indexed keywords

AUTOANTIBODY; GLYCOPROTEIN VI; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY;

ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOREACTIVITY; PLASMA; PRIORITY JOURNAL; SCREENING TEST; THROMBOCYTE ADHESION; THROMBOCYTE FUNCTION; THROMBOEMBOLISM; THROMBOGENESIS;

EID: 33745407707     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mbc.0000233371.26228.44     Document Type: Article

References (20)

1. Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood 2003; 102:449-461.
2. Best D, Senis YA, Jarvis GE, Eagleton HJ, Roberts DJ, Saito T, et al. GPVI levels in platelets: relationship to platelet function at high shear. Blood 2003; 102:2811-2818.
3. Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood 2000; 96:1798-1807.
4. Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, et al. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 2003; 102:1701-1707.
5. Olsson A, Andersson PO, Tengborn L, Wadenvik H. Serum from patients with chronic idiopathic thrombocytopenic purpura frequently affect the platelet function. Thromb Res 2002; 107:135-139.
6. Sugiyama T, Ishibashi T, Okuma M. Functional role of the antigen recognized by an antiplatelet antibody specific for a putative collagen receptor in platelet-collagen interaction. Int J Hematol 1993; 58:99-104.
7. Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, et al. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. Blood 2004; 104:1350-1355.
8. Karpatkin S. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet 1997; 349:1531-1536.
9. Hou M, Peng J, Shi Y, Zhang CQ, Qin P, Zhao CL, et al. Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haernatol 2003; 70:353-357.
10. Deckmyn H, Vanhoorelbeke K, Peerlinck K. Inhibitory and activating human antiplatelet antibodies. Baillieres Clin Haematol 1998; 11:343-359.
11. Dickfeld T, Ruf A, Pogatsa-Murray G, Muller I, Engelmann B, Taubitz W, et al. Differential antiplatelet effects of various glycoprotein IIb-IIIa antagonists. Thromb Res 2001; 101:53-64.
12. Coller BS. GPIIb/IIIa antagonists: pathophysiologic and therapeutic insights from studies of c7E3 Fab. Thromb Haemost 1997; 78:730-735.
13. Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave JP, et al. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med 2001; 193:459-469.
14. Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhofer D, et al. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003; 197:41-49.
15. Qian MD, Villeval JL, Xiong X, Jandrot-Perrus M, Nagashima K, Tonra J, et al. Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library. Hum Antibodies 2002; 11:97-105.
16. Smethurst PA, Joutsi-Korhonen L, O'Connor MN, Wilson E, Jennings NS, Garner SF, et al. Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood 2004; 103:903-911.
17. McMillan R. The pathogenesis of chronic immune (idiopathic) thrombocytopenic purpura. Semin Hematol 2000; 37 (Suppl 1):5-9.
18. Rand ML, Dean JA. Platelet function in autoimmune (idiopathic) thrombocytopenic purpura. Acta Paediatr Suppl 1998; 424:57-60.
19. Stockelberg D, Hou M, Jacobsson S, Kutti J, Wadenvik H. Light chain-restricted autoantibodies in chronic idiopathic thrombocytopenic purpura, but no evidence for circulating clone B-lymphocytes. Ann Hematol 1996; 72:29-34.
20. McMillan R, Lopez-Dee J, Bowditch R. Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP. Thromb Haemost 2001; 85:821-823.