Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery

American Journal of Physiology

Volumn 273, Issue 3 PART 1, 1997, Pages

  Holste, Linda C ^a   Connolly, Cynthia C ^a   Moore, Mary Courtney ^a   Neal, Doss W ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glycogen; Glycogen synthase; Hyperglycemia; Insulin; Liver

Indexed keywords

EID: 33745397007     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Abumrad, N. N., A. D. Cherrington, P. E. Williams, W. W. Lacy, and D. Rabin. Absorption and disposition of a glucose load in the conscious dog. Am. J. Physiol. 242 (Endocrinol. Metab. 5): E398-E406, 1982.
2. Adkins, B. A., S. R. Myers, G. K. Hendrick, R. W. Stevenson, P. E. Williams, and A. D. Cherrington. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J. Clin. Invest. 79: 557-565, 1987.
3. Allsop, J. R., R. R. Wolfe, and J. F. Burke. The reliability of rates of glucose appearance in vivo calculated from constant tracer infusions. Biochem. J. 172: 407-416, 1978.
4. Biolo, G., P. Tessari, S. Inchiostro, D. Bruttomesso, C. Fongher, L. Sabadin, M. G. Fratton, A. Valerio, and A. Tiengo. Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E455-E463, 1992.
5. Chan, T. M., and J. H. Exton. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal. Biochem. 71: 96-105, 1976.
6. Cherrington, A. D., R. W. Stevenson, K. E. Steiner, M. A. Davis, S. R. Myers, B. A. Adkins, N. N. Abumrad, and P. E. Williams. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab. Rev. 3: 307-332, 1987.
7. Cobelli, C., A. Mari, and E. Ferrannini. Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E679-E689, 1987.
8. Dinneen, S., A. Alazid, D. Turk, and R. Rizza. Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM. Diabetologia 38: 337-343, 1995.
9. Elia, M., P. Folmer, A. Schlatmann, A. Goren, and S. Austin. Carbohydrate, fat, and protein metabolism in muscle and in the whole body after mixed meal ingestion. Metabolism 37: 542-551, 1988.
10. Finegood, D. T., B. N. Bergman, and M. Vranic. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Diabetes 36: 914-924, 1987.
11. Hartley, C. J., and J. S. Cole. An ultrasonic pulsed Doppier system for measuring blood flow in small vessels. J. Appl. Physlol. 37: 626-629, 1974.
12. Leevy, C. M., C. L. Mendenhall, W. Lesko, and M. M. Howard. Estimation of hepatic blood flow with indocyanine green. J. Clin. Invest. 41:1169-1179, 1962.
13. Liljenquist, J. E., G. L. Mueller, A. D. Cherrington, J. M. Perry, and D. Rabinowitz. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J. Clin. Endocrinol. Metab. 48: 171-175, 1979.
14. McGuinness, O. P., T. Fugiwara, S. Murrell, D. Bracy, D. Neal, D. O'Connor, and A. D. Cherrington. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E314-E322, 1993.
15. McMahon, J., H. Marsh, and B. Bizza. Comparison of the pattern of postprandial carbohydrate metabolism after ingestion of a glucose drink or a mixed meal. J. Clin. Endocrinol. Metab. 68: 647-653, 1989.
16. Moore, M. C., A. D. Cherrington, G. Cline, M. J. Pagliassotti, E. M. Jones, D. W. Neal, C. Badet, and G. I. Shulman. Sources of carbon for hepatic glycogen synthesis in the conscious dog.J. Clin. Invest. 88: 578-587, 1991.
17. Moore, M. C., P. Flakoll, M. J. Pagliassotti, C. Venable, M. Monohan, and A. D. Cherrington. Concomitant amino acid infusion decreases net hepatic glucose uptake (NHGU) during intraportal (Po) glucose administration (Abstract). Diabetes 44, Suppl. 1:90A, 1995.
18. Moore, M. C., M. J. Pagliassotti, L. L. Swift, J. Asher, J. Murrell, D. Neal, and A. D. Cherrington. Disposition of a mixed meal by the conscious dog. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E666-E675, 1994.
19. Moore, M. C., L. Rossetti, M. J. Pagliassotti, M. Monahan, C. Venable, D. Neal, and A. D. Cherrington. Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis. Am. J. Physiol. 271 (Endacrinol. Metab. 34): E215-E222, 1996.
20. Myers, S. R., D. W. Biggers, D. W. Neal, and A. D. Cherrington. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J. Clin. Invest. 88:158-167, 1991.
21. Myers, S. R., O. P. McGuinness, D. W. Neal, and A. D. Cherrington, Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J. Clin. Invest. 87: 930-939, 1991.
22. Nuttall, P. Q., and M. C. Gannon. An improved assay for hepatic synthase in liver extracts with emphasis on synthase R. Anal. Biochem. 178: 311-319, 1989.
23. Pagliassotti, M. J., L. C. Holste, M. C. Moore, D. W. Neal, and A. D. Cherrington. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J. Clin. Invest. 97: 81-91, 1996.
24. Schefler, W. C. Statistics: Concepts, and Applications. Menlo Park, CA: Benjamin/Cummings Publishing, 1988, p. 141-148.
25. Sherwin, R. S., M. Fisher, R. Hendler, and P. Felig. Hyperglucagonemia and blood glucose regulation in normal, obese, and diabetic subjects. N. Engl. J. Med. 294: 455-461, 1976.
26. Shulman, G. I., J. E. Liljenquist, P. E. Williams, W. W. Lacy, and A, D. Cherrington. Glucose disposal during insulinopenia in somatostatin-treated dogs: the roles of glucose and glucagon. J. Clin. Invest. 62: 487-491, 1978.
27. Stalhmans, W. Glucagon and liver glycogen metabolism. In: Glucagon I, edited by P. J. Lefèbvre. Berlin: Springer-Verlag, 1983, p. 291-314.
28. Unger, R. H., and P. J. Lefèbvre. Glucagon physiology. In: Glucagon, edited by P. J. Lefèbvre and R. H. Unger. Elmsford, NY: Pergamon, 1972, p. 213-244.
29. Van Schaftingen, E. Glycolysis revisited. Diabetologia 36: 581-588, 1993.