Image quality assessment of a pre-clinical flat-panel volumetric micro-CT scanner

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6142 I, Issue , 2006, Pages

  Du, Louise Y ^a,b   Lee, Ting Yim ^a,b,c   Holdsworth, David W ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Image quality; Micro CT; Performance evaluation; Small animal imaging; X ray

Indexed keywords

ANIMAL IMAGING; HUMAN DISEASES; MICRO-CT; PERFORMANCE EVALUATION; PERFUSION IMAGING; SMALL ANIMAL IMAGING; SPATIAL RESOLUTION;

DIAGNOSIS; DISEASES; IMAGE QUALITY; MEDICAL IMAGING; TUMORS; X RAYS;

COMPUTERIZED TOMOGRAPHY;

EID: 33745366060     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.650970     Document Type: Conference Paper

References (26)

1. Ritman EL. Molecular imaging in small animals-roles for micro-CT. J Cell Biochem Suppl 2002;39:116-124.
2. Wang G. Vannier MW. Micro-CT scanners for biomedical applications: an overview. Adv Imaging 2001;16:18-27.
3. Paulus MJ, Gleason SS, Kennel SJ, Hunsicker PR, Johnson DK. High resolution X-ray computed tomography: an emerging tool for small animal cancer research. Neoplasia 2000;2(1-2):62-70.
4. Paulus MJ, Sari-Sarraf H, Gleason SS, Bobrek M, Hicks JS, Johnson DK. A new x-ray computed tomography system for laboratory mouse imaging. IEEE Trans Nucl Sci 1999;43(3):538-564.
5. Paulus MJ, Gleason SS, Easterly ME, Foltz CJ. A review of high-resolution X-ray computed tomography and other imaging modalities for small animal research. Lab Anim (NY) 2001;30(3):36-45.
6. Hoffman JM, Croft BY. Future directions in small animal imaging. Lab Anim (NY) 2001;30(3):32-35.
7. Holdsworth DW, Thornton MM. Micro-CT in small animal and specimen imaging. Trends Biotech 2002;20(8):S34-39.
8. Silva MD, Savinainen A, Kapadia R, et al. Quantitative analysis of micro-CT imaging and histopathological signatures of experimental arthritis in rats. Mol Imaging 2004;3(4)312-318.
9. Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman JM. Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum 2000;43:175-183.
10. Bentley MD, Ortiz MC, Ritman EL, Romero JC. The use of microcomputed tomography to study microvasculature in small rodents. Am J Physiol Regul Integr Comp Physiol 2002;282(5):R1267-1279.
11. Ortiz MC, Garcia-Sanz A, Bentley MD, Fortepiani LA. Microcomputed tomography of kidneys following chronic bile duct ligation. Kidney Int 2000;58(4):1632-1640.
12. Wan S-Y, Kiraly AP, Ritman EL, Higgins WE, Extraction of the hepatic vasculature in rats using 3-D micro-CT images. IEEE Trans Med Imaging 2000;19(9):964-971.
13. Lerman A, Ritman EL. Evaluation of microvascular anatomy by micro-CT. Herz 1999;24(7):531-533.
14. Ritman EL. Micro-computed tomography-current status and developments. Annu Rev Biomed Eng 2004;6:185-208.
15. Lee TY, Belesky V, Kalapos P, Lee D, Hachinski V, Spence D. CT perfusion imaging in cerebral ischemia. Stroke 2005;36(1):1-3; author reply 1-3.
16. Lee TY, Purdie TG, Stewart E. CT imaging of angiogenesis. Q J Nucl Med 2003;47(3):171-187.
17. Purdie TG, Henderson E, Lee TY. Functional CT imaging of angiogenesis in rabbit VX2 softtissue tumour. Phys Med Biol 2001;46(12):3161-3175.
18. Lee TY. Functional CT: physiological models. Trends Biotech 2002;20(8):S3-8.
19. Greschus S, Kiessling F, Lichy MP, et al. Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging. Neoplasia 2005;7(8):730-740.
20. Kiessling F, Greschus S, Lichy MP, et al. Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med 2004;10(10):1133-1138.
21. Feldkamp LA, Davis LC, Kress JW. Practical cone-beam algorithm. J Opt Soc Am A 1984; 1:612-619.
22. Judy PF. The line spread function and modulation transfer function of a computed tomographic scanner. Med Phys 1976;3(4):233-236.
23. Ford NL, Thornton MM, Holdsworth DW. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 2003;30(11):2869-2877.
24. Boone JM, Velazquez O, Cherry SR. Small-animal X-ray dose from micro-CT. Mol Imaging 2004;3(3):149-158.
25. Sato F, Sasaki S, Kawashima N, Chino F. Late effects of whole or partial body x-irradiation on mice: life shortening. Int J Radiat Biol Relat Stud Phys Chem Med 1981;39(6):607-615.
26. Paganetti H. Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. Int J Radiat Oncol Biol Phys 2005;63(3):892-900.