The non-steroidal anti-inflammatory drug, diclofenac, inhibits Na+ current in rat myoblasts

Biochemical and Biophysical Research Communications

Volumn 346, Issue 4, 2006, Pages 1275-1283

  Fei, Xiao Wei ^a   Liu, Lin Yun ^a   Xu, Jian Guang ^b   Zhang, Zhi Hong ^a   Mei, Yan Ai ^a  

^a Institute of Genetics   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Diclofenac; Na+ current; NSAIDs; Rat myoblasts; Voltage clamp

Indexed keywords

DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM ION;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; HYPERPOLARIZATION; MYOBLAST; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; STEADY STATE; VOLTAGE CLAMP; WHOLE CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; KINETICS; MEMBRANE POTENTIALS; MYOBLASTS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

EID: 33745348272     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.06.034     Document Type: Article

References (29)

1. Todd P.A., and Sorkin E.M. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 35 (1988) 244-285
2. Dawood M.Y. Nonsteroidal antiinflammatory drugs and reproduction. Am. J. Obstet. Gynecol. 169 (1993) 1255-1265
3. Small R.E. Diclofenac sodium. Clin. Pharmacol. 8 (1989) 545-558
4. Vane J.R. Introduction: mechanism of action of NSAIDs. Br. J. Rheumatol. 35 (1996) 1-3
5. Tonussi C.R., and Ferreira S.H. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur. J. Pharmacol. 251 (1994) 173-179
6. Asomoza-Espinosa R., Alonso-López R., Mixcoatl-Zecuatl T., Aguirre-Bañuelos P., Torres-López J.E., and Granados-Soto V. Sildenafil increases diclofenac antinociception in the formalin test. Eur. J. Pharmacol. 418 (2001) 195-200
7. + channels in the peripheral antinociceptive effect induced by dipyrone. Eur. J. Pharmacol. 444 (2002) 47-52
8. + channels by diclofenac. Eur. J. Pharmacol. 438 (2002) 85-91
9. Voilley N., de Weille J., Mamet J., and Lazdunski M. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J. Neurosci. 21 (2001) 8026-8033
10. Lee H.M., Kim H.I., Shin Y.K., Lee C.S., Park M., and Song J.H. Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons. Brain Res. 992 (2003) 120-127
11. + currents. Cell Motil. Cytoskeleton 58 (2004) 127-136
12. + current in rat cerebellar granule cells. Neuropharmacology 48 (2005) 918-926
13. Occhiodoro T., Bernheim L., Liu J.H., Bijlenga P., Sinnreich M., Bader C.R., and Fischer-Lougheed J. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 434 (1998) 177-182
14. 2+ signaling during terminal differentiation (fusion) of human myoblasts. Proc. Natl. Acad. Sci. USA 97 (2000) 7627-7632
15. Fischer-Lougheed J., Liu J.H., Espinos E., Mordasini D., Bader C.R., Belin D., and Bernheim L. Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels. J. Cell Biol. 153 (2001) 677-685
16. + current in rat myoblasts. Cell. Physiol. Biochem. 14 (2004) 225-230
17. + channel currents in rat myoblasts by 4-aminopyridine. Toxicol. Appl. Pharmacol. 207 (2005) 275-282
18. + current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol. Pharmacol. 57 (2000) 135-143
19. +. J. Gen. Physiol. 125 (2005) 465-481
20. Fozzard H.A., and Hanck D.A. Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. Physiol. Rev. 76 (1996) 887-926
21. Catterall W.A. From ionic current to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26 (2000) 13-25
22. Nuss H.B., Tomaselli G.F., and Marban E. Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (μ1) channels. J. Gen. Physiol. 106 (1995) 1193-1209
23. Li R.A., Ennis I.L., Tomaselli G.F., and Marban E. Structural basis of differences in isoform-specific gating and lidocaine blocking between cardiac and skeletal muscle sodium channels. Mol. Pharmacol. 61 (2002) 136-141
24. Goldin A.L. Resurgence of sodium channel research. Annu. Rev. Physiol. 63 (2001) 871-894
25. Goldin A.L. Diversity of mammalian voltage-gated sodium channels. Ann. N. Y. Acad. Sci. 868 (1999) 38-50
26. Butterworth J.F., and Strichartz G.R. Molecular mechanisms of local anesthesia: a review. Anesthesiology 72 (1990) 711-734
27. Laerum E., Ommundsen O.E., Gronseth J.E., Christiansen A., and Fagertun H.E. Oral diclofenac in the prophylactic treatment of recurrent renal colic. A double-blind comparison with placebo. Eur. Urol. 28 (1995) 108-111
28. Laerum E., and Murtagh J. Renal colic and recurrent urinary calculi. Management and prevention. Aust. Fam. Physician 30 (2001) 36-41
29. Jett M.F., Ramesha C.S., Brown C.D., Chiu S., Emmett C., Voronin T., Sun T., O'Yang C., Hunter J.C., Eglen R.M., and Johnson R.M. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J. Pharmacol. Exp. Ther. 288 (1999) 1288-1297