Aptamers selected for higher-affinity binding are not more specific for the target ligand

Journal of the American Chemical Society

Volumn 128, Issue 24, 2006, Pages 7929-7937

  Carothers, James M ^a,b   Oestreich, Stephanie C ^a,c   Szostak, Jack W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Berkeley   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; MOLECULAR STRUCTURE; PHOSPHATES; RNA; SUGARS;

APTAMERS; GUANOSINE TRIPHOSPHATE (GTP); LIGANDS;

NUCLEIC ACIDS;

APTAMER; COMPLEMENTARY RNA; FUNCTIONAL GROUP; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE DERIVATIVE; LIGAND;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; LIGAND BINDING; MOLECULAR INTERACTION; RNA BINDING; RNA RNA INTERACTION; RNA STABILITY; RNA STRUCTURE;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BINDING SITES; GUANOSINE TRIPHOSPHATE; LIGANDS; NUCLEIC ACID CONFORMATION; RNA;

EID: 33745347470     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja060952q     Document Type: Article

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