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Volumn 24, Issue 29-30, 2006, Pages 5655-5669

DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination

Author keywords

Biocompatible nanoparticles; Cellular responses; DNA vaccination; HIV 1 tat

Indexed keywords

DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MACROGOL; NANOPARTICLE; PLASMID DNA; POLY(METHYL METHACRYLATE); POLYMER; TRANSACTIVATOR PROTEIN;

EID: 33745284588     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.05.058     Document Type: Article
Times cited : (57)

References (68)
  • 1
    • 0034086797 scopus 로고    scopus 로고
    • DNA vaccines: a key for inducing long-term cellular immunity
    • Gurunathan S., Wu C.Y., and Seder R.A. DNA vaccines: a key for inducing long-term cellular immunity. Curr Opin Immunol 12 (2000) 442-447
    • (2000) Curr Opin Immunol , vol.12 , pp. 442-447
    • Gurunathan, S.1    Wu, C.Y.2    Seder, R.A.3
  • 2
    • 23244456102 scopus 로고    scopus 로고
    • DNA vaccines: progress and challenges
    • Donnelly J.J., Wahren B., and Liu M.A. DNA vaccines: progress and challenges. J Immunol 175 (2005) 633-639
    • (2005) J Immunol , vol.175 , pp. 633-639
    • Donnelly, J.J.1    Wahren, B.2    Liu, M.A.3
  • 3
    • 17444435761 scopus 로고    scopus 로고
    • Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients
    • Calarota S., Bratt G., Nordlund S., Hinkula J., Leandersson A.C., Sandstrom E., et al. Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients. Lancet 351 (1998) 1320-1325
    • (1998) Lancet , vol.351 , pp. 1320-1325
    • Calarota, S.1    Bratt, G.2    Nordlund, S.3    Hinkula, J.4    Leandersson, A.C.5    Sandstrom, E.6
  • 4
    • 0032538597 scopus 로고    scopus 로고
    • Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
    • Wang R., Doolan D.L., Le T.P., Hedstrom R.C., Coonan K.M., Charoenvit Y., et al. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282 (1998) 476-480
    • (1998) Science , vol.282 , pp. 476-480
    • Wang, R.1    Doolan, D.L.2    Le, T.P.3    Hedstrom, R.C.4    Coonan, K.M.5    Charoenvit, Y.6
  • 5
    • 25144454136 scopus 로고    scopus 로고
    • Non-viral vector as vaccine carrier
    • Chen W.C., and Huang L. Non-viral vector as vaccine carrier. Adv Gen 54 (2005) 315-337
    • (2005) Adv Gen , vol.54 , pp. 315-337
    • Chen, W.C.1    Huang, L.2
  • 7
    • 0031753113 scopus 로고    scopus 로고
    • Design and delivery of non-parental vaccines
    • Nugent J., Wan Po L., and Scott E. Design and delivery of non-parental vaccines. J Clin Pharm Ther 23 (1998) 257-285
    • (1998) J Clin Pharm Ther , vol.23 , pp. 257-285
    • Nugent, J.1    Wan Po, L.2    Scott, E.3
  • 8
    • 0030942803 scopus 로고    scopus 로고
    • Characterization of liposome-mediated gene delivery. Expression, stability and pharmacokinetics of plasmid DNA
    • Thierry A.R., Rabinovich P., Peng B., Mahan L.C., Bryant J.L., and Gallo R.C. Characterization of liposome-mediated gene delivery. Expression, stability and pharmacokinetics of plasmid DNA. Gene Ther 4 (1997) 226-237
    • (1997) Gene Ther , vol.4 , pp. 226-237
    • Thierry, A.R.1    Rabinovich, P.2    Peng, B.3    Mahan, L.C.4    Bryant, J.L.5    Gallo, R.C.6
  • 9
    • 2942601682 scopus 로고    scopus 로고
    • Microparticles for the delivery of DNA vaccines
    • O'Hagan D.T., Singh M., and Ulmer J.B. Microparticles for the delivery of DNA vaccines. Immunol Rev 199 (2004) 191-200
    • (2004) Immunol Rev , vol.199 , pp. 191-200
    • O'Hagan, D.T.1    Singh, M.2    Ulmer, J.B.3
  • 10
    • 0034182386 scopus 로고    scopus 로고
    • Nano and microparticles as controlled drug delivery devices
    • Majeti N.V., and Kumar R. Nano and microparticles as controlled drug delivery devices. J Pharm Sci 3 (2000) 234-258
    • (2000) J Pharm Sci , vol.3 , pp. 234-258
    • Majeti, N.V.1    Kumar, R.2
  • 12
    • 0030590503 scopus 로고    scopus 로고
    • Biocompatibility of biomaterials: hemocompatibility, immunocompatibility and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers
    • Rihova B. Biocompatibility of biomaterials: hemocompatibility, immunocompatibility and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers. Adv Drug Deliv Rev 21 (1996) 157-176
    • (1996) Adv Drug Deliv Rev , vol.21 , pp. 157-176
    • Rihova, B.1
  • 13
    • 0035997326 scopus 로고    scopus 로고
    • Genetic immunization using nanoparticles engineered from microemulsion precursors
    • Cui Z., and Mumper R.J. Genetic immunization using nanoparticles engineered from microemulsion precursors. Pharm Res 19 (2002) 939-946
    • (2002) Pharm Res , vol.19 , pp. 939-946
    • Cui, Z.1    Mumper, R.J.2
  • 14
    • 0037123697 scopus 로고    scopus 로고
    • Topical immunization using nanoengineered genetic vaccines
    • Cui Z., and Mumper R.J. Topical immunization using nanoengineered genetic vaccines. J Control Release 81 (2002) 173-184
    • (2002) J Control Release , vol.81 , pp. 173-184
    • Cui, Z.1    Mumper, R.J.2
  • 15
    • 0036733907 scopus 로고    scopus 로고
    • Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses
    • Cui Z., and Mumper R.J. Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses. J Pharm Pharmacol 54 (2002) 1195-1203
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1195-1203
    • Cui, Z.1    Mumper, R.J.2
  • 16
    • 19544389448 scopus 로고    scopus 로고
    • Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination
    • Oster C.G., Kim N., Grode L., Barbu-Tudoran L., Schaper A.K., Kaufmann S.H., et al. Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination. J Control Release 104 (2005) 359-377
    • (2005) J Control Release , vol.104 , pp. 359-377
    • Oster, C.G.1    Kim, N.2    Grode, L.3    Barbu-Tudoran, L.4    Schaper, A.K.5    Kaufmann, S.H.6
  • 17
    • 3142526410 scopus 로고    scopus 로고
    • Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles
    • Mollenkopf H.J., Dietrich G., Fensterle J., Grode L., Diehl K.D., Knapp B., et al. Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles. Vaccine 22 (2004) 2690-2695
    • (2004) Vaccine , vol.22 , pp. 2690-2695
    • Mollenkopf, H.J.1    Dietrich, G.2    Fensterle, J.3    Grode, L.4    Diehl, K.D.5    Knapp, B.6
  • 18
    • 0032862290 scopus 로고    scopus 로고
    • Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines
    • Jabbal-Gill I., Lin W., Jenkins P., Jimenez M., Illum L., Davis S.S., et al. Potential of polymeric lamellar substrate particles (PLSP) as adjuvants for vaccines. Vaccine 18 (1999) 238-250
    • (1999) Vaccine , vol.18 , pp. 238-250
    • Jabbal-Gill, I.1    Lin, W.2    Jenkins, P.3    Jimenez, M.4    Illum, L.5    Davis, S.S.6
  • 19
    • 0029071816 scopus 로고
    • A single administration of tetanus toxoid in biodegradable microspheres elicit T cell and antibody responses similar or superior to those obtained with aluminium hydroxide
    • Men Y., Thomasin C., Merkle H., and Gander B. A single administration of tetanus toxoid in biodegradable microspheres elicit T cell and antibody responses similar or superior to those obtained with aluminium hydroxide. Vaccine 13 (1995) 683-689
    • (1995) Vaccine , vol.13 , pp. 683-689
    • Men, Y.1    Thomasin, C.2    Merkle, H.3    Gander, B.4
  • 20
    • 0343247711 scopus 로고    scopus 로고
    • Biodegradation and biocompatibility of PLA and PLGA microspheres
    • Anderson J.M., and Shive M.S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 28 (1997) 5-24
    • (1997) Adv Drug Deliv Rev , vol.28 , pp. 5-24
    • Anderson, J.M.1    Shive, M.S.2
  • 21
    • 0025834747 scopus 로고
    • Biodegradable and biocompatible poly(d, l-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies
    • Eldridge J.H., Staas J.K., Meulbroek J.A., Tice T.R., and Gilley R.M. Biodegradable and biocompatible poly(d, l-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect Immun 59 (1991) 2978-2986
    • (1991) Infect Immun , vol.59 , pp. 2978-2986
    • Eldridge, J.H.1    Staas, J.K.2    Meulbroek, J.A.3    Tice, T.R.4    Gilley, R.M.5
  • 22
    • 0034601247 scopus 로고    scopus 로고
    • Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination
    • Johansen P., Men Y., Merkle H.P., and Gander B. Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination. Eur J Pharm Biopharm 50 (2000) 129-146
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 129-146
    • Johansen, P.1    Men, Y.2    Merkle, H.P.3    Gander, B.4
  • 23
    • 85044700671 scopus 로고    scopus 로고
    • Recent advances in vaccine adjuvants for systemic and mucosal administration
    • O'Hagan D.T. Recent advances in vaccine adjuvants for systemic and mucosal administration. J Pharm Pharmacol 59 (1998) 1-10
    • (1998) J Pharm Pharmacol , vol.59 , pp. 1-10
    • O'Hagan, D.T.1
  • 24
    • 0035502382 scopus 로고    scopus 로고
    • Recent developments in vaccine delivery systems
    • O'Hagan D.T. Recent developments in vaccine delivery systems. Curr Drug Targets Infect Disord 1 (2001) 273-286
    • (2001) Curr Drug Targets Infect Disord , vol.1 , pp. 273-286
    • O'Hagan, D.T.1
  • 25
    • 0027305289 scopus 로고
    • Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles
    • O'Hagan D.T., Jeffery H., and Davis S.S. Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles. Vaccine 11 (1993) 965-969
    • (1993) Vaccine , vol.11 , pp. 965-969
    • O'Hagan, D.T.1    Jeffery, H.2    Davis, S.S.3
  • 27
    • 0343516410 scopus 로고
    • Adjuvants and the mucosal immune system
    • Spriggs D.R., and Koff W.C. (Eds), CRC, Boca Raton
    • Nedrud J.G., and Lamm M.E. Adjuvants and the mucosal immune system. In: Spriggs D.R., and Koff W.C. (Eds). Topics in vaccine adjuvant research (1991), CRC, Boca Raton 51-67
    • (1991) Topics in vaccine adjuvant research , pp. 51-67
    • Nedrud, J.G.1    Lamm, M.E.2
  • 28
    • 17644426388 scopus 로고    scopus 로고
    • Adsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2 SF162) to anionic PLG microparticles retains the structural integrity of the protein, whereas encapsulation in PLG microparticles does not
    • Singh M., Chesko J., Kazzaz J., Ugozzoli M., Kan E., Srivastava I., et al. Adsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2 SF162) to anionic PLG microparticles retains the structural integrity of the protein, whereas encapsulation in PLG microparticles does not. Pharm Res 21 (2004) 2148-2152
    • (2004) Pharm Res , vol.21 , pp. 2148-2152
    • Singh, M.1    Chesko, J.2    Kazzaz, J.3    Ugozzoli, M.4    Kan, E.5    Srivastava, I.6
  • 29
    • 28444435109 scopus 로고    scopus 로고
    • Stability of bovine serum albumin complexed with PEG-poly(l-histidine) diblock copolymer in PLGA microspheres
    • Kim J.H., Taluja A., Knutson K., and Han Bae Y. Stability of bovine serum albumin complexed with PEG-poly(l-histidine) diblock copolymer in PLGA microspheres. J Control Release 109 (2005) 86-100
    • (2005) J Control Release , vol.109 , pp. 86-100
    • Kim, J.H.1    Taluja, A.2    Knutson, K.3    Han Bae, Y.4
  • 30
    • 0034849493 scopus 로고    scopus 로고
    • Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines
    • O'Hagan D., Singh M., Ugozzoli M., Wild C., Barnett S., Chen M., et al. Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines. J Virol 75 (2001) 9037-9043
    • (2001) J Virol , vol.75 , pp. 9037-9043
    • O'Hagan, D.1    Singh, M.2    Ugozzoli, M.3    Wild, C.4    Barnett, S.5    Chen, M.6
  • 31
    • 12844272901 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine
    • Xie H., Gursel I., Ivins B.E., Singh M., O'Hagan D.T., Ulmer J.B., et al. CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infect Immun 73 (2005) 828-833
    • (2005) Infect Immun , vol.73 , pp. 828-833
    • Xie, H.1    Gursel, I.2    Ivins, B.E.3    Singh, M.4    O'Hagan, D.T.5    Ulmer, J.B.6
  • 32
    • 20844448215 scopus 로고    scopus 로고
    • Cationic microparticles are a potent delivery system for a HCV DNA vaccine
    • O'Hagan D.T., Singh M., Dong C., Ugozzoli M., Berger K., Glazer E., et al. Cationic microparticles are a potent delivery system for a HCV DNA vaccine. Vaccine 23 (2004) 672-680
    • (2004) Vaccine , vol.23 , pp. 672-680
    • O'Hagan, D.T.1    Singh, M.2    Dong, C.3    Ugozzoli, M.4    Berger, K.5    Glazer, E.6
  • 33
  • 34
    • 0842289361 scopus 로고    scopus 로고
    • Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B
    • Singh M., Kazzaz J., Chesko J., Soenawan E., Ugozzoli M., Giuliani M., et al. Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B. J Pharm Sci 93 (2004) 273-282
    • (2004) J Pharm Sci , vol.93 , pp. 273-282
    • Singh, M.1    Kazzaz, J.2    Chesko, J.3    Soenawan, E.4    Ugozzoli, M.5    Giuliani, M.6
  • 35
    • 0025869514 scopus 로고
    • High antibody titers in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines
    • Stieneker F., Kreuter J., and Lower J. High antibody titers in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines. AIDS 5 (1991) 431-435
    • (1991) AIDS , vol.5 , pp. 431-435
    • Stieneker, F.1    Kreuter, J.2    Lower, J.3
  • 36
    • 4544301217 scopus 로고    scopus 로고
    • Recent advances in the development of HIV-1 Tat-based vaccines
    • Caputo A., Gavioli R., and Ensoli B. Recent advances in the development of HIV-1 Tat-based vaccines. Curr HIV Res 2 (2004) 357-376
    • (2004) Curr HIV Res , vol.2 , pp. 357-376
    • Caputo, A.1    Gavioli, R.2    Ensoli, B.3
  • 37
    • 9244262981 scopus 로고    scopus 로고
    • Nonstructural HIV proteins as targets for prophylactic or therapeutic vaccines
    • Ferrantelli F., Cafaro A., and Ensoli B. Nonstructural HIV proteins as targets for prophylactic or therapeutic vaccines. Curr Opin Biotechnol 15 (2004) 543-556
    • (2004) Curr Opin Biotechnol , vol.15 , pp. 543-556
    • Ferrantelli, F.1    Cafaro, A.2    Ensoli, B.3
  • 38
    • 0034276087 scopus 로고    scopus 로고
    • Core shell functional nanospheres for oligonucleotide delivery. III. Stealth nanospheres
    • Sparnacci K., Tondelli L., and Laus M. Core shell functional nanospheres for oligonucleotide delivery. III. Stealth nanospheres. J Polym Sci, Polym Chem 38 (2000) 3347-3354
    • (2000) J Polym Sci, Polym Chem , vol.38 , pp. 3347-3354
    • Sparnacci, K.1    Tondelli, L.2    Laus, M.3
  • 39
    • 0022510846 scopus 로고
    • Purification and physicochemical properties of polyacrylic nanoparticles
    • Rolland A., Gibassier D., Sado P., and Le Verge R. Purification and physicochemical properties of polyacrylic nanoparticles. J Pharm Belg 41 (1986) 94-105
    • (1986) J Pharm Belg , vol.41 , pp. 94-105
    • Rolland, A.1    Gibassier, D.2    Sado, P.3    Le Verge, R.4
  • 41
  • 42
    • 0024754766 scopus 로고
    • Studies on suspension and emulsion. 58. Xps analysis (esca) of the surface-composition of poly(styrene 2-hydroxyethyl methacrylate) microspheres produced by emulsifier-free emulsion polymerization
    • Okubo M., Yamamoto Y., and Kamei S. Studies on suspension and emulsion. 58. Xps analysis (esca) of the surface-composition of poly(styrene 2-hydroxyethyl methacrylate) microspheres produced by emulsifier-free emulsion polymerization. Colloid Polym Sci 267 (1989) 861-865
    • (1989) Colloid Polym Sci , vol.267 , pp. 861-865
    • Okubo, M.1    Yamamoto, Y.2    Kamei, S.3
  • 43
    • 0021967217 scopus 로고
    • The trans-activator gene of human T-lymphotropic virus type III (HTLV-III)
    • Arya S.K., Guo C., Joseph S.F., and Wong-Staal F. The trans-activator gene of human T-lymphotropic virus type III (HTLV-III). Science 229 (1985) 69-73
    • (1985) Science , vol.229 , pp. 69-73
    • Arya, S.K.1    Guo, C.2    Joseph, S.F.3    Wong-Staal, F.4
  • 44
    • 0023037537 scopus 로고
    • Expression and characterization of the trans-activator of HTLV-III/LAV virus
    • Wright C.M., Felber B.K., Paskalis H., and Pavlakis G.N. Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science 234 (1986) 988-992
    • (1986) Science , vol.234 , pp. 988-992
    • Wright, C.M.1    Felber, B.K.2    Paskalis, H.3    Pavlakis, G.N.4
  • 45
    • 0025240391 scopus 로고
    • Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector
    • Caputo A., Sodroski J.G., and Haseltine W.A. Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector. J Acquir Immune Defic Syndr 3 (1990) 372-379
    • (1990) J Acquir Immune Defic Syndr , vol.3 , pp. 372-379
    • Caputo, A.1    Sodroski, J.G.2    Haseltine, W.A.3
  • 46
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 47
    • 0037424111 scopus 로고    scopus 로고
    • Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat
    • Caputo A., Gavioli R., Altavilla G., Brocca-Cofano E., Boarini C., Betti M., et al. Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat. Vaccine 21 (2003) 1103-1111
    • (2003) Vaccine , vol.21 , pp. 1103-1111
    • Caputo, A.1    Gavioli, R.2    Altavilla, G.3    Brocca-Cofano, E.4    Boarini, C.5    Betti, M.6
  • 48
    • 0027458469 scopus 로고
    • Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation
    • Ensoli B., Buonaguro L., Barillari G., Fiorelli V., Gendelman R., Morgan R.A., et al. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 67 (1993) 277-287
    • (1993) J Virol , vol.67 , pp. 277-287
    • Ensoli, B.1    Buonaguro, L.2    Barillari, G.3    Fiorelli, V.4    Gendelman, R.5    Morgan, R.A.6
  • 49
    • 0030862924 scopus 로고    scopus 로고
    • HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region
    • Chang H.C., Samaniego F., Nair B.C., Buonaguro L., and Ensoli B. HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. AIDS 11 (1997) 1421-1431
    • (1997) AIDS , vol.11 , pp. 1421-1431
    • Chang, H.C.1    Samaniego, F.2    Nair, B.C.3    Buonaguro, L.4    Ensoli, B.5
  • 50
    • 0036136322 scopus 로고    scopus 로고
    • Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    • Fanales-Belasio E., Moretti S., Nappi F., Barillari G., Micheletti F., Cafaro A., et al. Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses. J Immunol 168 (2002) 197-206
    • (2002) J Immunol , vol.168 , pp. 197-206
    • Fanales-Belasio, E.1    Moretti, S.2    Nappi, F.3    Barillari, G.4    Micheletti, F.5    Cafaro, A.6
  • 51
    • 4143058116 scopus 로고    scopus 로고
    • Codon optimization of the tat antigen of human immunodeficiency virus type 1 generates strong immune responses in mice following genetic immunization
    • Ramakrishna L., Anand K.K., Mohankumar K.M., and Ranga U. Codon optimization of the tat antigen of human immunodeficiency virus type 1 generates strong immune responses in mice following genetic immunization. J Virol 78 (2004) 9174-9189
    • (2004) J Virol , vol.78 , pp. 9174-9189
    • Ramakrishna, L.1    Anand, K.K.2    Mohankumar, K.M.3    Ranga, U.4
  • 52
    • 4644302152 scopus 로고    scopus 로고
    • HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity
    • Gavioli R., Gallerani E., Fortini C., Fabris M., Bottoni A., Canella A., et al. HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity. J Immunol 173 (2004) 3838-3843
    • (2004) J Immunol , vol.173 , pp. 3838-3843
    • Gavioli, R.1    Gallerani, E.2    Fortini, C.3    Fabris, M.4    Bottoni, A.5    Canella, A.6
  • 53
    • 3142538773 scopus 로고    scopus 로고
    • Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application
    • Caputo A., Brocca-Cofano E., Castaldello A., De Michele R., Altavilla G., Marchisio M., et al. Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application. Vaccine 22 (2004) 2910-2924
    • (2004) Vaccine , vol.22 , pp. 2910-2924
    • Caputo, A.1    Brocca-Cofano, E.2    Castaldello, A.3    De Michele, R.4    Altavilla, G.5    Marchisio, M.6
  • 55
    • 0033136285 scopus 로고    scopus 로고
    • DNA immunization with HIV-1 tat mutated in the transactivation domain induces humoral and cellular immune response against wild-type Tat
    • Caselli E., Betti M., Grossi M.P., Balboni P.G., Rossi C., Boarini C., et al. DNA immunization with HIV-1 tat mutated in the transactivation domain induces humoral and cellular immune response against wild-type Tat. J Immunol 162 (1999) 5631-5638
    • (1999) J Immunol , vol.162 , pp. 5631-5638
    • Caselli, E.1    Betti, M.2    Grossi, M.P.3    Balboni, P.G.4    Rossi, C.5    Boarini, C.6
  • 56
    • 9244259077 scopus 로고    scopus 로고
    • DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells
    • Jilek S., Merkle H.P., and Walter E. DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells. Adv Drug Deliv Rev 57 (2005) 377-390
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 377-390
    • Jilek, S.1    Merkle, H.P.2    Walter, E.3
  • 57
    • 0031637377 scopus 로고    scopus 로고
    • Biodegradable polymer microspheres as vaccine adjuvants and delivery systems
    • Gupta R.K., Chang A.C., and Siber G.R. Biodegradable polymer microspheres as vaccine adjuvants and delivery systems. Dev Biol Stand 92 (1998) 63-78
    • (1998) Dev Biol Stand , vol.92 , pp. 63-78
    • Gupta, R.K.1    Chang, A.C.2    Siber, G.R.3
  • 58
    • 2942620224 scopus 로고    scopus 로고
    • Strong T cell type-1 immune responses to HIV-1 Tat (1-72) protein-coated nanoparticles
    • Cui Z., Patel J., Tuzova M., Ray P., Phillips R., Woodward J.G., et al. Strong T cell type-1 immune responses to HIV-1 Tat (1-72) protein-coated nanoparticles. Vaccine 22 (2004) 2631-2640
    • (2004) Vaccine , vol.22 , pp. 2631-2640
    • Cui, Z.1    Patel, J.2    Tuzova, M.3    Ray, P.4    Phillips, R.5    Woodward, J.G.6
  • 59
    • 3142530535 scopus 로고    scopus 로고
    • Immunogenicity of a cationic microparticle-adsorbed plasmid DNA encoding Japanase encephalistis virus envelope protein
    • Kaur R., Rauthan M., and Vrati S. Immunogenicity of a cationic microparticle-adsorbed plasmid DNA encoding Japanase encephalistis virus envelope protein. Vaccine 22 (2004) 2776-2782
    • (2004) Vaccine , vol.22 , pp. 2776-2782
    • Kaur, R.1    Rauthan, M.2    Vrati, S.3
  • 60
    • 0038709309 scopus 로고    scopus 로고
    • Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles
    • Otten G., Schaefer M., Greer C., Calderon-Cacia M., Coit D., Kazzaz J., et al. Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles. J Virol 77 (2003) 6087-6092
    • (2003) J Virol , vol.77 , pp. 6087-6092
    • Otten, G.1    Schaefer, M.2    Greer, C.3    Calderon-Cacia, M.4    Coit, D.5    Kazzaz, J.6
  • 61
    • 0344982963 scopus 로고    scopus 로고
    • Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles
    • Denis-Mize K.S., Dupuis M., Singh M., Woo C., Ugozzoli M., O'Hagan D.T., et al. Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles. Cell Immunol 225 (2003) 12-20
    • (2003) Cell Immunol , vol.225 , pp. 12-20
    • Denis-Mize, K.S.1    Dupuis, M.2    Singh, M.3    Woo, C.4    Ugozzoli, M.5    O'Hagan, D.T.6
  • 63
    • 20444433853 scopus 로고    scopus 로고
    • Covalent conjugation of polyethyleneimine on biodegradable microparticles for delivery of plasmid DNA vaccines
    • Kasturi S.P., Sachaphibulkij K., and Roy K. Covalent conjugation of polyethyleneimine on biodegradable microparticles for delivery of plasmid DNA vaccines. Biomaterials 26 (2005) 6375-6385
    • (2005) Biomaterials , vol.26 , pp. 6375-6385
    • Kasturi, S.P.1    Sachaphibulkij, K.2    Roy, K.3
  • 64
    • 0017288984 scopus 로고
    • New adjvants on a polymethylmethacrylate base
    • Kreuter J., and Speiser P.P. New adjvants on a polymethylmethacrylate base. Infect Immunol 13 (1976) 204-210
    • (1976) Infect Immunol , vol.13 , pp. 204-210
    • Kreuter, J.1    Speiser, P.P.2
  • 65
    • 17444447880 scopus 로고    scopus 로고
    • Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes
    • Hinkula J., Svanholm C., Schawartz S., Lundholm P., Brytting M., Engstrom G., et al. Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes. J Virol 71 (1997) 5528-5539
    • (1997) J Virol , vol.71 , pp. 5528-5539
    • Hinkula, J.1    Svanholm, C.2    Schawartz, S.3    Lundholm, P.4    Brytting, M.5    Engstrom, G.6
  • 66
    • 0030752480 scopus 로고    scopus 로고
    • Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses
    • Hinkula J., Lundholm P., and Wahren B. Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses. Vaccine 15 (1997) 874-878
    • (1997) Vaccine , vol.15 , pp. 874-878
    • Hinkula, J.1    Lundholm, P.2    Wahren, B.3
  • 67
    • 0035961544 scopus 로고    scopus 로고
    • DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector
    • Tahtinem M., Strengell M., Collings A., Pitkanen J., Kjerrstrom A., Hakkarainen K., et al. DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector. Vaccine 19 (2001) 2039-2047
    • (2001) Vaccine , vol.19 , pp. 2039-2047
    • Tahtinem, M.1    Strengell, M.2    Collings, A.3    Pitkanen, J.4    Kjerrstrom, A.5    Hakkarainen, K.6
  • 68
    • 0035815501 scopus 로고    scopus 로고
    • Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P)
    • Cafaro A., Titti F., Fracasso C., Maggiorella M.T., Baroncelli S., Caputo A., et al. Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P). Vaccine 19 (2001) 2862-2877
    • (2001) Vaccine , vol.19 , pp. 2862-2877
    • Cafaro, A.1    Titti, F.2    Fracasso, C.3    Maggiorella, M.T.4    Baroncelli, S.5    Caputo, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.