메뉴 건너뛰기




Volumn 80, Issue 13, 2006, Pages 6399-6410

Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; LYSINE; RNA DIRECTED DNA POLYMERASE; TENOFOVIR; VIRUS RNA;

EID: 33745272288     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02308-05     Document Type: Article
Times cited : (13)

References (77)
  • 1
    • 0037108794 scopus 로고    scopus 로고
    • Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: Risk without reward
    • Abbas, U. L., and J. W. Mellors. 2002. Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: risk without reward. Proc. Natl. Acad. Sci. USA 99:13377-13378.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13377-13378
    • Abbas, U.L.1    Mellors, J.W.2
  • 2
    • 0035058439 scopus 로고    scopus 로고
    • Improving immune function and controlling viral replication in HIV-1-infected patients with immune-based therapies
    • Angel, J. B. 2001. Improving immune function and controlling viral replication in HIV-1-infected patients with immune-based therapies. AIDS Reader 11:209-221.
    • (2001) AIDS Reader , vol.11 , pp. 209-221
    • Angel, J.B.1
  • 5
    • 0037053373 scopus 로고    scopus 로고
    • Association of chemokine-mediated block to HIV entry with coreceptor internalization
    • Brandt, S. M., R. Mariani, A. U. Holland, T. J. Hope, and N. R. Landau. 2002. Association of chemokine-mediated block to HIV entry with coreceptor internalization. J. Biol. Chem. 277:17291-17299.
    • (2002) J. Biol. Chem. , vol.277 , pp. 17291-17299
    • Brandt, S.M.1    Mariani, R.2    Holland, A.U.3    Hope, T.J.4    Landau, N.R.5
  • 7
    • 0038806648 scopus 로고    scopus 로고
    • Management of severely immunocompromised human immunodeficiency virus type 1-infected African orphans with structured treatment interruption: Another kind of salvage therapy
    • Chakraborty, R., R. Musoke, T. Palakudy, A. Cross, and A. D'Agostino. 2003. Management of severely immunocompromised human immunodeficiency virus type 1-infected African orphans with structured treatment interruption: another kind of salvage therapy. Clin. Infect. Dis. 36:1483-1485.
    • (2003) Clin. Infect. Dis. , vol.36 , pp. 1483-1485
    • Chakraborty, R.1    Musoke, R.2    Palakudy, T.3    Cross, A.4    D'Agostino, A.5
  • 9
    • 0034946066 scopus 로고    scopus 로고
    • Durable HIV treatment benefit despite low-level viremia. Reassessing definitions of success or failure
    • Decks, S. G. 2001. Durable HIV treatment benefit despite low-level viremia. Reassessing definitions of success or failure. JAMA 286:224-226.
    • (2001) JAMA , vol.286 , pp. 224-226
    • Decks, S.G.1
  • 10
    • 0037436291 scopus 로고    scopus 로고
    • Persistence of drug-resistant HIV-1 after a structured treatment interruption and its impact on treatment response
    • Deeks, S. G., R. M. Grant, T. Wrin, E. E. Paxinos, T. Liegler, R. Hoh, J. N. Martin, and C. J. Petropoulos. 2003. Persistence of drug-resistant HIV-1 after a structured treatment interruption and its impact on treatment response. AIDS 17:361-370.
    • (2003) AIDS , vol.17 , pp. 361-370
    • Deeks, S.G.1    Grant, R.M.2    Wrin, T.3    Paxinos, E.E.4    Liegler, T.5    Hoh, R.6    Martin, J.N.7    Petropoulos, C.J.8
  • 11
    • 9144231780 scopus 로고    scopus 로고
    • Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1
    • Deeks, S. G., J. N. Martin, E. Sinclair, J. Harris, T. B. Neilands, H. T. Maecker, E. Hagos, T. Wrin, C. J. Petropoulos, B. Bredt, and J. M. McCune. 2004. Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1. J. Infect. Dis. 189:312-321.
    • (2004) J. Infect. Dis. , vol.189 , pp. 312-321
    • Deeks, S.G.1    Martin, J.N.2    Sinclair, E.3    Harris, J.4    Neilands, T.B.5    Maecker, H.T.6    Hagos, E.7    Wrin, T.8    Petropoulos, C.J.9    Bredt, B.10    McCune, J.M.11
  • 13
    • 0033819349 scopus 로고    scopus 로고
    • Characterization of lymphocyte subsets in rhesus macaques during the first year of life
    • DeMaria, M. A., M. Casto, M. O'Connell, R. P. Johnson, and M. Rosenzweig. 2000. Characterization of lymphocyte subsets in rhesus macaques during the first year of life. Eur. J. Haematol. 65:245-257.
    • (2000) Eur. J. Haematol. , vol.65 , pp. 245-257
    • DeMaria, M.A.1    Casto, M.2    O'Connell, M.3    Johnson, R.P.4    Rosenzweig, M.5
  • 14
    • 0037032905 scopus 로고    scopus 로고
    • Expansion of preterminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption
    • D'Offizi, G., C. Montesano, C. Agrati, C. Gioia, M. Amicosante, S. Topino, P. Narciso, L. P. Pucillo, G. Ippolito, and F. Poccia. 2002. Expansion of preterminally differentiated CD8 T cells in chronic HIV-positive patients presenting a rapid viral rebound during structured treatment interruption. AIDS 16:2431-2438.
    • (2002) AIDS , vol.16 , pp. 2431-2438
    • D'Offizi, G.1    Montesano, C.2    Agrati, C.3    Gioia, C.4    Amicosante, M.5    Topino, S.6    Narciso, P.7    Pucillo, L.P.8    Ippolito, G.9    Poccia, F.10
  • 19
    • 0033020671 scopus 로고    scopus 로고
    • Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV
    • Evans, D. T., L. A. Knapp, P. Jing, J. L. Mitchen, M. Dykhuizen, D. C. Montefiori, C. D. Pauza, and D. I. Watkins. 1999. Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV. Immunol. Lett. 66:53-59.
    • (1999) Immunol. Lett. , vol.66 , pp. 53-59
    • Evans, D.T.1    Knapp, L.A.2    Jing, P.3    Mitchen, J.L.4    Dykhuizen, M.5    Montefiori, D.C.6    Pauza, C.D.7    Watkins, D.I.8
  • 22
    • 15544387158 scopus 로고    scopus 로고
    • Simian immunodeficiency virus (SIV) envelope quasi-species transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: Increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals
    • Online
    • Greenier, J. L., K. K. A. Van Rompay, D. Monteflori, P. Earl, B. Moss, and M. L. Marthas. 2005. Simian immunodeficiency virus (SIV) envelope quasi-species transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals. Virol. J. 2:11. [Online.] http://www.virologyj.com/content/2/1/11.
    • (2005) Virol. J. , vol.2 , pp. 11
    • Greenier, J.L.1    Van Rompay, K.K.A.2    Monteflori, D.3    Earl, P.4    Moss, B.5    Marthas, M.L.6
  • 24
    • 0032874020 scopus 로고    scopus 로고
    • Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj
    • Hodge, S., J. De Rosayro, A. Glenn, I. C. Ojukwu, S. Dewhurst, H. M. McClure, N. Bischofberger, D. C. Anderson, S. A. Klumpp, and F. J. Novembre. 1999. Postinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj. J. Virol. 73:8630-8639.
    • (1999) J. Virol. , vol.73 , pp. 8630-8639
    • Hodge, S.1    De Rosayro, J.2    Glenn, A.3    Ojukwu, I.C.4    Dewhurst, S.5    McClure, H.M.6    Bischofberger, N.7    Anderson, D.C.8    Klumpp, S.A.9    Novembre, F.J.10
  • 25
    • 20844451906 scopus 로고    scopus 로고
    • Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated
    • Johnson, J. A., J. F. Li, L. Morris, N. Martinson, G. Gray, J. McIntyre, and W. Heneine. 2005. Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated. J. Infect. Dis. 192:16-23.
    • (2005) J. Infect. Dis. , vol.192 , pp. 16-23
    • Johnson, J.A.1    Li, J.F.2    Morris, L.3    Martinson, N.4    Gray, G.5    McIntyre, J.6    Heneine, W.7
  • 26
    • 33751027170 scopus 로고    scopus 로고
    • A sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase
    • in press
    • Johnson, J. A., K. K. A. Van Rompay, E. Delwart, and W. Heneine. A sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase. AIDS Res. Hum. Retrovir., in press.
    • AIDS Res. Hum. Retrovir.
    • Johnson, J.A.1    Van Rompay, K.K.A.2    Delwart, E.3    Heneine, W.4
  • 27
    • 0028788331 scopus 로고
    • The appearance of drug resistance-associated point mutations in HIV type 1 plasma RNA precedes their appearance in proviral DNA
    • Kaye, S., E. Comber, M. Tenant-Flowers, and C. Loveday. 1995. The appearance of drug resistance-associated point mutations in HIV type 1 plasma RNA precedes their appearance in proviral DNA. AIDS Res. Hum. Retrovir. 11:1221-1225.
    • (1995) AIDS Res. Hum. Retrovir. , vol.11 , pp. 1221-1225
    • Kaye, S.1    Comber, E.2    Tenant-Flowers, M.3    Loveday, C.4
  • 28
    • 0031452947 scopus 로고    scopus 로고
    • A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing
    • Knapp, L. A., E. Lehmann, M. S. Piekarczyk, J. A. Urvater, and D. I. Walkins. 1997. A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens 50:657-661.
    • (1997) Tissue Antigens , vol.50 , pp. 657-661
    • Knapp, L.A.1    Lehmann, E.2    Piekarczyk, M.S.3    Urvater, J.A.4    Walkins, D.I.5
  • 29
    • 0035915990 scopus 로고    scopus 로고
    • Development of virus-specific immune responses in SHIVKU-infected macaques treated with PMPA
    • Kumar, A., S. Buch, L. Foresman, N. Bischofberger, J. D. Lifson, and O. Narayan. 2001. Development of virus-specific immune responses in SHIVKU-infected macaques treated with PMPA. Virology 279:97-108.
    • (2001) Virology , vol.279 , pp. 97-108
    • Kumar, A.1    Buch, S.2    Foresman, L.3    Bischofberger, N.4    Lifson, J.D.5    Narayan, O.6
  • 33
    • 0035915372 scopus 로고    scopus 로고
    • Structured treatment interruptions for the management of HIV infection
    • Lori, F., and J. Lisziewicz. 2001. Structured treatment interruptions for the management of HIV infection. JAMA 286:2981-2987.
    • (2001) JAMA , vol.286 , pp. 2981-2987
    • Lori, F.1    Lisziewicz, J.2
  • 34
    • 0037234103 scopus 로고    scopus 로고
    • Therapeutic dendritic-cell vaccine for simian AIDS
    • Lu, W., X. Wu, Y. Lu, W. Guo, and J.-M. Andrieu. 2003. Therapeutic dendritic-cell vaccine for simian AIDS. Nat. Med. 9:27-32.
    • (2003) Nat. Med. , vol.9 , pp. 27-32
    • Lu, W.1    Wu, X.2    Lu, Y.3    Guo, W.4    Andrieu, J.-M.5
  • 35
    • 17544371675 scopus 로고    scopus 로고
    • Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: Control of viral replication and absence of persistent HIV-1-specific immune responses
    • Luzuriaga, K., M. McManus, M. Catalina, S. Mayack, M. Sharkey, M. Stevenson, and J. L. Sullivan. 2000. Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses. J. Virol. 74:6984-6991.
    • (2000) J. Virol. , vol.74 , pp. 6984-6991
    • Luzuriaga, K.1    McManus, M.2    Catalina, M.3    Mayack, S.4    Sharkey, M.5    Stevenson, M.6    Sullivan, J.L.7
  • 36
    • 1242296969 scopus 로고    scopus 로고
    • Highly uneven distribution of tenofovir-selected simian immunodeficiency virus drug resistance genotypes in different anatomical sites of rhesus macaques
    • Magierowska, M., F. Bernardin, S. Garg, S. Staprans, M. D. Miller, K. K. A. Van Rompay, and E. L. Delwart. 2004. Highly uneven distribution of tenofovir-selected simian immunodeficiency virus drug resistance genotypes in different anatomical sites of rhesus macaques. J. Virol. 78:2434-2444.
    • (2004) J. Virol. , vol.78 , pp. 2434-2444
    • Magierowska, M.1    Bernardin, F.2    Garg, S.3    Staprans, S.4    Miller, M.D.5    Van Rompay, K.K.A.6    Delwart, E.L.7
  • 39
    • 11244304648 scopus 로고    scopus 로고
    • Treatment interruption for virologie failure or as sparing regimen in children with chronic HIV-I infection
    • Monpoux, F., J. Tricoire, M. Lalande, V. Reliquet, B. Bebin, and I. Thuret. 2004. Treatment interruption for virologie failure or as sparing regimen in children with chronic HIV-I infection. AIDS 18:2401-2409.
    • (2004) AIDS , vol.18 , pp. 2401-2409
    • Monpoux, F.1    Tricoire, J.2    Lalande, M.3    Reliquet, V.4    Bebin, B.5    Thuret, I.6
  • 40
    • 13944274099 scopus 로고    scopus 로고
    • Structured treatment interruptions: A risky business
    • Montaner, J., M. Harris, and R. Hogg. 2005. Structured treatment interruptions: a risky business. Clin. Infect. Dis. 40:601-603.
    • (2005) Clin. Infect. Dis. , vol.40 , pp. 601-603
    • Montaner, J.1    Harris, M.2    Hogg, R.3
  • 41
    • 19944423187 scopus 로고    scopus 로고
    • Evaluating neutralizing antibodies against HIV, SIV and SHIV in luciferase reporter gene assays
    • J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, and R. Coico (ed.). John Wiley & Sons, Inc., Hoboken, N.J.
    • Montefiori, D. C. 2004. Evaluating neutralizing antibodies against HIV, SIV and SHIV in luciferase reporter gene assays, p. 12.11.1-12.11.15. In J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, and R. Coico (ed.), Current protocols in immunology. John Wiley & Sons, Inc., Hoboken, N.J.
    • (2004) Current Protocols in Immunology
    • Montefiori, D.C.1
  • 42
    • 0037227585 scopus 로고    scopus 로고
    • Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251
    • Nacsa, J., J. Stanton, K. J. Kunstman, W.-P. Tsai, D. I. Watkins, S. M. Wolinsky, and G. Franchini. 2003. Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251. Virology 305:210-218.
    • (2003) Virology , vol.305 , pp. 210-218
    • Nacsa, J.1    Stanton, J.2    Kunstman, K.J.3    Tsai, W.-P.4    Watkins, D.I.5    Wolinsky, S.M.6    Franchini, G.7
  • 46
    • 0242384226 scopus 로고    scopus 로고
    • Detection of antigen-specific T cell interferon γ expression by ELISPOT and cytokine flow cytometry assays in rhesus macaques
    • Pahar, B., J. Li, T. Rourke, C. J. Miller, and M. B. McChesney. 2003. Detection of antigen-specific T cell interferon γ expression by ELISPOT and cytokine flow cytometry assays in rhesus macaques. J. Immunol. Methods 282:103-115.
    • (2003) J. Immunol. Methods , vol.282 , pp. 103-115
    • Pahar, B.1    Li, J.2    Rourke, T.3    Miller, C.J.4    McChesney, M.B.5
  • 52
    • 20144386998 scopus 로고    scopus 로고
    • Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: Multicentre cohort study
    • First published 4 March 2005; doi: 10.1136/bmj.38369.669850.8F
    • Sabin, C. A., T. Hill, F. Lampe, R. Matthias, S. Bhagani, R. Gilson, M. S. Youle, M. A. Johnson, M. Fisher, G. Scullard, P. Easterbrook, B. Gazzard, A. Phillips, and the UK Collaborative HIV Cohort (UK CHIC) Study Group. 2005. Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study. Br. Med. J. 330:695. (First published 4 March 2005; doi: 10.1136/bmj.38369. 669850.8F.)
    • (2005) Br. Med. J. , vol.330 , pp. 695
    • Sabin, C.A.1    Hill, T.2    Lampe, F.3    Matthias, R.4    Bhagani, S.5    Gilson, R.6    Youle, M.S.7    Johnson, M.A.8    Fisher, M.9    Scullard, G.10    Easterbrook, P.11    Gazzard, B.12    Phillips, A.13
  • 57
    • 23144468115 scopus 로고    scopus 로고
    • Antiretroviral drug studies in non-human primates: A valid animal model for innovative drug efficacy and pathogenesis studies
    • Van Rompay, K. K. A. 2005. Antiretroviral drug studies in non-human primates: a valid animal model for innovative drug efficacy and pathogenesis studies. AIDS Rev. 7:67-83.
    • (2005) AIDS Rev. , vol.7 , pp. 67-83
    • Van Rompay, K.K.A.1
  • 62
    • 0032974787 scopus 로고    scopus 로고
    • Early short-term 9-2-(phosphonomethoxy) propyljadenine (PMPA) treatment favorably alters subsequent disease course in simian immunodeficiency virus-infected newborn rhesus macaques
    • Van Rompay, K. K. A., P. J. Dailey, R. P. Tarara, D. R. Canfield, N. L. Aguirre, J. M. Cherrington, P. D. Lamy, N. Bischofberger, N. C. Pedersen, and M. L. Marthas. 1999. Early short-term 9-[2-(phosphonomethoxy) propyljadenine (PMPA) treatment favorably alters subsequent disease course in simian immunodeficiency virus-infected newborn rhesus macaques. J. Virol. 73:2947-2955.
    • (1999) J. Virol. , vol.73 , pp. 2947-2955
    • Van Rompay, K.K.A.1    Dailey, P.J.2    Tarara, R.P.3    Canfield, D.R.4    Aguirre, N.L.5    Cherrington, J.M.6    Lamy, P.D.7    Bischofberger, N.8    Pedersen, N.C.9    Marthas, M.L.10
  • 64
    • 3242659521 scopus 로고    scopus 로고
    • Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion
    • Van Rompay, K. K. A., M. L. Marthas, and N. Bischofberger. 2004. Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion. Antivir. Res. 63:133-138.
    • (2004) Antivir. Res. , vol.63 , pp. 133-138
    • Van Rompay, K.K.A.1    Marthas, M.L.2    Bischofberger, N.3
  • 66
    • 0026471599 scopus 로고
    • Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: Oral 3′-azido-3′-deoxythymidine prevents SIV infection
    • Van Rompay, K. K. A., M. L. Marthas, R. A. Ramos, C. P. Mandell, E. K. McGowan, S. M. Joye, and N. C. Pedersen. 1992. Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral 3′-azido-3′-deoxythymidine prevents SIV infection. Antimicrob. Agents Chemother. 36:2381-2386.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2381-2386
    • Van Rompay, K.K.A.1    Marthas, M.L.2    Ramos, R.A.3    Mandell, C.P.4    McGowan, E.K.5    Joye, S.M.6    Pedersen, N.C.7
  • 69
    • 0033947591 scopus 로고    scopus 로고
    • Prophylactic and therapeutic benefits of short-term 9-[2- (phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA
    • Van Rompay, K. K. A., M. D. Miller, M. L. Marthas, N. A. Margot, P. J. Dailey, R. P. Tarara, D. R. Canfield, J. M. Cherrington, N. L. Aguirre, N. Bischofberger, and N. C. Pedersen. 2000. Prophylactic and therapeutic benefits of short-term 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA. J. Virol. 74:1767-1774.
    • (2000) J. Virol. , vol.74 , pp. 1767-1774
    • Van Rompay, K.K.A.1    Miller, M.D.2    Marthas, M.L.3    Margot, N.A.4    Dailey, P.J.5    Tarara, R.P.6    Canfield, D.R.7    Cherrington, J.M.8    Aguirre, N.L.9    Bischofberger, N.10    Pedersen, N.C.11
  • 73
    • 0030771289 scopus 로고    scopus 로고
    • Absence of viral rebound after treatment of HIV-infected patients with didanosine and hydroxycarbamide
    • Vila, J., F. Nugier, G. Bargues, T. Vallet, D. Peyramond, F. Hamedi-Sangsari, and J. M. Seigneurin. 1997. Absence of viral rebound after treatment of HIV-infected patients with didanosine and hydroxycarbamide. Lancet 350:635-636.
    • (1997) Lancet , vol.350 , pp. 635-636
    • Vila, J.1    Nugier, F.2    Bargues, G.3    Vallet, T.4    Peyramond, D.5    Hamedi-Sangsari, F.6    Seigneurin, J.M.7
  • 75
    • 4744365211 scopus 로고    scopus 로고
    • Response to highly active antiretroviral therapy varies with age: The UK and Ireland Collaborative HIV Paediatric Study
    • Walker, A. S., K. Doerholt, M. Sharland, and D. M. Gibb. 2004. Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study. AIDS 18:1915-1924.
    • (2004) AIDS , vol.18 , pp. 1915-1924
    • Walker, A.S.1    Doerholt, K.2    Sharland, M.3    Gibb, D.M.4
  • 76
    • 0036839746 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity
    • White, K. L., N. A. Margot, T. Wrin, C. J. Petropoulos, M. D. Miller, and L. K. Naeger. 2002. Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity. Antimicrob. Agents Chemother. 46:3437-3446.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3437-3446
    • White, K.L.1    Margot, N.A.2    Wrin, T.3    Petropoulos, C.J.4    Miller, M.D.5    Naeger, L.K.6
  • 77
    • 4744346009 scopus 로고    scopus 로고
    • Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions
    • Yerly, S., H. F. Gunthard, C. Fagard, B. Joos, T. V. Perneger, B. Hirschel, and L. Perrin. 2004. Proviral HIV-DNA predicts viral rebound and viral setpoint after structured treatment interruptions. AIDS 18:1951-1953.
    • (2004) AIDS , vol.18 , pp. 1951-1953
    • Yerly, S.1    Gunthard, H.F.2    Fagard, C.3    Joos, B.4    Perneger, T.V.5    Hirschel, B.6    Perrin, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.