On the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 7, 2006, Pages 1546-1552

  Fernandes, R S ^a   Kirszberg, C ^a   Rumjanek, V M ^a   Monteiro, Robson Q ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Blood procoagulant complexes; C6 glioma; Phosphatidylserine; Thrombin; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 12A; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9A; LIPOCORTIN 5; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; PLASMA PROTEIN; PROTHROMBIN; THROMBIN; THROMBOPLASTIN;

ANIMAL CELL; ARTICLE; BINDING SITE; BLOOD CLOTTING; CELL LINE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ASSAY; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; FLOW CYTOMETRY; GLIOMA; HUMANS; NEOPLASM PROTEINS; PHOSPHATIDYLSERINES; RATS; THROMBIN; THROMBOPLASTIN;

EID: 33745249525     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01985.x     Document Type: Article

References (39)

1. Mann KG. Biochemistry and physiology of blood coagulation. Thromb Haemost 1999; 82: 165-74.
2. Morrissey JH. Tissue factor: An enzyme cofactor and a true receptor. Thromb Haemost 2001; 86: 66-74.
3. Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 2002; 22: 1381-9.
4. Otten HM, Prins MH. Venous thromboembolism and occult malignancy. Thromb Res 2001; 102: V187-94.
5. Rickles FR, Falanga A. Molecular basis for the relationship between thrombosis and cancer. Thromb Res 2001; 102: V215-24.
6. Sugimura M, Donato R, Kakkar VV, Scully MF. Annexin V as a probe of the contribution of anionic phospholipids to the procoagulant activity of tumour cell surfaces. Blood Coagul Fibrinolysis 1994; 5: 365-73.
7. Rickles FR, Patierno S, Fernandez PM. Tissue factor, thrombin, and cancer. Chest 2003; 124: 58S- 68S.
8. VanDeWater L, Tracy PB, Aronson D, Mann KG, Dvorak HF. Tumor cell generation of thrombin via functional prothrombinase assembly. Cancer Res 1985; 45: 5521-5.
9. Kirszberg C, Rumjanek VM, Monteiro RQ. Assembly and regulation of prothrombinase complex on B16F10 melanoma cells. Thromb Res 2005; 115: 123-9.
10. Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 1998; 4: 909-14.
11. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 2005; 25: 1545-50.
12. Hamada K, Kuratsu J, Saitoh Y, Takeshima H, Nishi T, Ushio Y. Expression of tissue factor correlates with grade of malignancy in human glioma. Cancer 1996; 77: 1877-83.
13. Takano S, Tsuboi K, Tomono Y, Mitsui Y, Nose T. Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression. Br J Cancer 2000; 82: 1967-73.
14. Guan M, Jin J, Su B, Liu WW, Lu Y. Tissue factor expression and angiogenesis in human glioma. Clin Biochem 2002; 35: 321-5.
15. Ishimaru K, Hirano H, Yamahata H, Takeshima H, Niiro M, Kuratsu J. The expression of tissue factor correlates with proliferative ability in meningioma. Oncol Rep 2003; 10: 1133-7.
16. Ogiichi T, Hirashima Y, Nakamura S, Endo S, Kurimoto M, Takaku A. Tissue factor and cancer procoagulant expressed by glioma cells participate in their thrombin-mediated proliferation. J Neurooncol 2000; 46: 1-9.
17. Hua Y, Keep RF, Schallert T, Hoff JT, Xi G. A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model. Acta Neurochir Suppl 2003; 86: 503-6.
18. Hua Y, Tang L, Keep RF, Schallert T, Fewel ME, Muraszko KM, Hoff JT, Xi G. The role of thrombin in gliomas. J Thromb Haemost 2005; 3: 1917-23.
19. Bernstein JJ, Goldberg WJ, Laws ER, Conger D, Morreale V, Wood L. C6 glioma cell invasion and migration of rat brain after neural homografting: Ultrastructure. Neurosurgery 1990; 26: 622-8.
20. Holland EC. Glioblastoma multiforme: The terminator. Proc Natl Acad Sci USA 2000; 97: 6242-4.
21. Grobben B, De Deyn PP, Slegers H. Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion. Cell Tissue Res 2002; 310: 257-70.
22. Bezeaud A, Denninger MH, Guillin MC. Interaction of human α-thrombin and γ-thrombin with antithrombin III, protein C and thrombomodulin. Eur J Biochem 1985; 153: 491-6.
23. Ngai PK, Chang JY. A novel one-step purification of human α-thrombin after direct activation of crude prothrombin enriched from plasma. Biochem J 1991; 280: 805-8.
24. Astermark J, Hogg PJ, Bjork I, Stenflo J. Effects of gamma-carboxyglutamic acid and epidermal growth factor-like modules of factor IX on factor X activation. Studies using proteolytic fragments of bovine factor IX. J Biol Chem 1992; 267: 3249-56.
25. Francischetti IM, Valenzuela JG, Ribeiro JM. Anophelin: Kinetics and mechanism of thrombin inhibition. Biochemistry 1999; 38: 16678-85.
26. Carson SD, Pirruccello SJ. Tissue factor and cell morphology variations in cell lines subcloned from U87-MG. Blood Coagul Fibrinolysis 1998; 9: 539-47.
27. Mielicki WP, Gordon SG. Three-stage chromogenic assay for the analysis of activation properties of factor X by cancer procoagulant. Blood Coagul Fibrinolysis 1993; 4: 441-6.
28. Brat DJ, Van Meir EG. Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma. Lab Invest 2004; 84: 397-405.
29. Sawaya R, Yamamoto M, Ramo OJ, Shi ML, Rayford A, Rao JS. Plasminogen activator inhibitor-1 in brain tumors: Relation to malignancy and necrosis. Neurosurgery 1995; 36: 375-80.
30. Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res 2005; 65: 1406-13.
31. Fadul CE, Zacharski LR. Coagulation biology in glioma pathogenesis: A missing link ? J Thromb Haemost 2005; 3: 1915-6.
32. Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, Devi SN, Kaur B, Van Meir EG. Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 2004; 64: 920-7.
33. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis 1996; 7: 536-48.
34. Ornstein DL, Meehan KR, Zacharski LR. The coagulation system as a target for the treatment of human gliomas. Semin Thromb Hemost 2002; 28: 19-28.
35. Tsopanoglou NE, Maragoudakis ME. Role of thrombin in angiogenesis and tumor progression. Semin Thromb Hemost 2004; 30: 63-9.
36. Hjortoe GM, Petersen LC, Albrektsen T, Sorensen BB, Norby PL, Mandal SK, Pendurthi UR, Rao LV. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 2004; 103: 3029-37.
37. Jiang X, Bailly MA, Panetti TS, Cappello M, Konigsberg WH, Bromberg ME. Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells. J Thromb Haemost 2004; 2: 93-101.
38. Kaufmann R, Bone B, Westermann M, Nowak G, Ramakrishnan V. Investigation of PAR-1-type thrombin receptors in rat glioma C6 cells with a novel monoclonal anti-PAR-1 antibody (Mab COR7-6H9). J Neurocytol 1998; 27: 661-6.
39. 2+]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells. Neuroscience 1998; 86: 597-609.