Role of protein kinase Cα in melatonin signal transduction

Molecular and Cellular Endocrinology

Volumn 252, Issue 1-2, 2006, Pages 82-87

  Sampson, S R ^a   Lupowitz, Z ^b   Braiman, L ^a   Zisapel, N ^b  

^a BAR ILAN UNIVERSITY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Androgen receptor; Melatonin; Prostate; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ANDROGEN RECEPTOR; HISPIDIN; MELATONIN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FAMILY; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WILD TYPE;

CELL LINE, TUMOR; CELL MEMBRANE; CYTOSOL; HUMANS; KINETICS; MALE; MELATONIN; PROSTATIC NEOPLASMS; PROTEIN KINASE C-ALPHA; SIGNAL TRANSDUCTION;

EID: 33745202296     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2006.03.033     Document Type: Article

References (18)

1. Benitez-King G., Hernandez M.E., Tovar R., and Ramirez G. Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells. Neurochem. Int. 39 (2001) 95-102
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Dekker L.V., and Parker P.J. Protein kinase C--a question of specificity. Trends Biochem. Sci. 19 (1994) 73-77
4. Gilad E., Matzkin H., and Zisapel N. Inactivation of melatonin receptors by protein kinase C in human prostate epithelial cells. Endocrinology 138 (1997) 4255-4261
5. Koren R., Ben Meir D., Langzam L., Dekel Y., Konichezky M., Baniel J., Livne P.M., Gal R., and Sampson S.R. Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Oncol. Rep. 11 (2004) 321-326
6. Lamm M.L., Long D.D., Goodwin S.M., and Lee C. Transforming growth factor-beta1 inhibits membrane association of protein kinase C alpha in a human prostate cancer cell line PC3. Endocrinology 138 (1997) 4657-4664
7. Lupowitz Z., Rimler A., and Zisapel N. Evaluation of signal transduction pathways mediating the nuclear exclusion of the androgen receptor by melatonin. Cell Mol. Life Sci. 58 (2001) 2129-2135
8. Lupowitz Z., and Zisapel N. Hormonal interactions in human prostate tumor LNCaP cells. J. Steroid Biochem. Mol. Biol. 68 1-2 (1999) 83-88
9. Moretti, R.M., Marelli, M.M., Maggi, R., Dondi, D., Motta, M., Limonta, P., 2000. Antiproliferative action of melatonin on human prostate cancer LNCaP cells.
10. Newton A.C. Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270 (1995) 28495-28498
11. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258 (1992) 607-614
12. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9 (1995) 484-496
13. Powell C.T., Brittis N.J., Stec D., Hug H., Heston W.D.W., and Fair W.R. Persistent membrane translocation of protein kinase Cα during 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells. Cell Growth Differ. 7 (1996) 419-428
14. Rimler A., Culig Z., Levy-Rimler G., Lupowitz Z., Klocker H., Matzkin H., Bartsch G., and Zisapel N. Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity. Prostate 49 (2001) 145-154
15. Rimler A., Culig Z., Lupowitz Z., and Zisapel N. Nuclear exclusion of the androgen receptor by melatonin. J. Steroid Biochem. Mol. Biol. 81 (2002) 77-84
16. Rimler A., Lupowitz Z., and Zisapel N. Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells. Neuro. Endocrinol. Lett. 23 Suppl. 1 (2002) 45-49
17. Wu D., and Terrian D.M. Regulation of caveolin-1 expression and secretion by a protein kinase cepsilon signaling pathway in human prostate cancer cells. J. Biol. Chem. 25 277 (2002) 40449-40455
18. Xi S.C., Siu S.W., Fong S.W., and Shiu S.Y. Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression. Prostate 46 (2001) 52-61