Aprotinin does not diminish blood loss in elective operations for infrarenal abdominal aneurysms: A randomized double-blind controlled trial

Annals of Vascular Surgery

Volumn 20, Issue 3, 2006, Pages 322-329

  Leijdekkers, Vanessa J ^a,d   Vahl, Anco C ^a   Mackaay, Albert J C ^b   Huijgens, Peter C ^c   Rauwerda, Jan A ^c  

^a ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^b MEANDER MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ANTIPLASMIN; APROTININ; BLOOD CLOTTING FACTOR; KALLIKREIN; PLACEBO; SODIUM CHLORIDE;

ABDOMINAL AORTA ANEURYSM; AGED; ARTICLE; BLOOD SAMPLING; CHI SQUARE TEST; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SCREENING; ELECTIVE SURGERY; FEMALE; FIBRINOLYSIS; HUMAN; MALE; MORBIDITY; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; RENAL ARTERY ANEURYSM; RISK ASSESSMENT; STUDENT T TEST; SUCTION; SURGICAL MORTALITY;

EID: 33745196938     PISSN: 08905096     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10016-006-9043-x     Document Type: Article

References (33)

1. Nypayer TJ, Shepard AD, Reddy DJ. Repair of pararenal abdominal aortic aneurysms. Arch Surg 1993;7:97-102.
2. Vahl AC, Mackaay AJ, Huijgens PC, et al. Haemostasis during infrarenal aortic aneurysm surgery: effect of volume loading and cross-clamping. Eur J Vasc Endovasc Surg 1997;13:60-65.
3. Pull ter Gunne AJ, Bruining HA, Obertop H. Haemodynamics and "optimal" hydration in aortic cross clamping. Neth J Surg 1990;42:113-117.
4. De Van Mol Otterloo JC, Van Bockel JH, Ponfoort ED, et al. Systemic effects of collagen-impregnated aortoiliac Dacron vascular prostheses on platelet activation and fibrin formation. J Vasc Surg 1991;14:59-66.
5. Snellen JP, Terpstra OT, van Urk H. The use of a straight tube graft decreases blood loss and operation time in patients with an abdominal aortic aneurysm. Neth J Surg 1984;36:45-47.
6. Wills A, Thompson MM, Crowther M, et al. Pathogenesis of abdominal aortic aneurysms - cellular and biochemical mechanisms. Eur J Vasc Endovasc Surg 1996;12:391-400.
7. Gibney EJ, Bouchier-Hayes D. Coagulopathy and abdominal aortic aneurysm. Eur J Vasc Surg 1990;4:557-562.
8. Murphy WG, Davies MJ, Eduardo A. The haemostatic response to surgery and trauma. Br J Anaesth 1993;70:205-213.
9. von Sommoggy S, Fraunhofer S, Wahba A, et al. Coagulation in aortofemoral bifurcation bypass grafting. Eur J Vasc Surg 1991;5:247-253.
10. Becquemin JP, Chemla E, Chatellier G, et al. Peroperative factors influencing the outcome of elective abdominal aorta aneurysm repair. Eur J Vasc Endovasc. Surg. 2000;20:84-89.
11. Thompson RW, Adams DH, Cohen JR, et al. Disseminated intravascular coagulation caused by abdominal aortic aneurysm. J Vasc Surg 1986;4:184-186.
12. Bailey CR, Kelleher AA, Wielogorski AK. Randomized placebo-controlled double-blind study of three aprotinin regimens in primary surgery. Br J Surg 1994;81:969-973.
13. Bailey CR, Wielogorski AK. Randomized placebo controlled double blind study of two low dose aprotinin regimens in cardiac surgery. Br Heart J 1994;71:349-353.
14. Carrel T, Bauer E, Laske A, et al. Low-dose aprotinin for reduction of blood loss after cardiopulmonary bypass. Lancet 1991;337:673.
15. Cosgrove DM, Heric B, Lytle BW, et al. Aprotinin therapy for reoperative myocardial revascularization: a placebo-controlled study. Ann Thorac Surg 1992;54:1031-1036.
16. Levy JH, Pifarre R, Schaff HV, et al. A multicenter double blind placebo controlled trial of aprotinin for reducing blood loss and requirement for donor blood transfusion in patients undergoing repeat coronary artery bypass grafting. Circulation 1995;8:2236-2244.
17. Rich JB. The efficacy and safety of aprotinin use in cardiac surgery. Ann Thorac Surg 1998;66(5 Suppl.):S6-S11.
18. Royston D. High-dose aprotinin therapy: a review of the first five years' experience. J Cardiothorac Vasc Anesth 1992;6:76-100.
19. van Oeveren W, Harder MP, Roozendaal KJ, et al. Aprotinin protects platelets against the initial effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990;99:788-796.
20. Levi M, Cromheecke ME, de Jonge E, et al. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Lancet 1999;354:1940-1947.
21. Bradfield JF, Bode AP. Aprotinin restores the adhesive capacity of dysfunctional platelets. Thromb Res 2003;109:181-188.
22. Carr ME, Carr SL, Roa V, et al. Aprotinin counteracts heparin induced inhibition of paltelet contractile force. Thromb Res 2003;108:161-168.
23. Kozek-Langenecker SA, Mohammed SF, Masaki T, et al. The effects of aprotinin on platelets in vitro using whole blood flow cytometry. Anesth Analg 2000;90:12-16.
24. Landis RC, Asimakopoulos G, Poullis M, et al. The antithrombotic and antiinflammatory mechanisms of action of aprotinin. Ann Thorac Surg 2001;72:2169-2175.
25. Landis RC, Haskard DO, Taylor KM. New antiinflammatory and platelet-preserving effects of aprotinin. Ann Thorac Surg 2001;72:s1808-s1813.
26. Asimakopoulos G, Thompson R, Nourshargh S, et al. An anti-inflammatory property of aprotinin detected at the level of leucocyte extravasation. J Thorac Cardiovasc Surg 2000;120:361-369.
27. Preufer D, Makowski J, Dahm M, et al. Aprotin inhibits leucocyte-endothelial cell interactions after hemorrahage and reperfusion. Ann Thorac Surg 2003;75:210-216.
28. Ranaboldo CJ, Thompson JF, Davies JN, et al. Prospective randomized placebo-controlled trial of aprotinin for elective aortic reconstruction. Br J Surg 1997;84:1110-1113.
29. Robinson J, Nawaz S, Beard JD. Randomized, multicentre, double-blind, placebo-controlled trial of the use of aprotinin in the repair of ruptured abdominal aortic aneurysm. On behalf of the Joint Vascular Research Group. Br J Surg 2000;87:754-757.
30. Beath SM, Nuttall GA, Fass DN, et al. plasma aprotinin concentrations during cardiac surgery: full vs half dose regims. Anesth Analg 2000;91:257-264.
31. Kyriss T, Wurst H, Friedel G, et al. Reduced blood loss by aprotinin in thoracic surgical operations assosiated with high risk of bleeding. Eur J Cardiothorac Surg 2001;20:38-41.
32. Haynes SL, Wong JCL, Torella F, et al. The influence of homologous blood transfusion on immunity and clinical outcome in aortic surgery. Eur J Vasc Endovasc Surg 2001;22:244-250.
33. de Penta Peppo A, Pierri MD, Scafuri A, et al. Intraoperative antifibrinolysis and blood-saving techniques in cardiac surgery. Tex. Heart Inst J 1995;22:231-236.