The accumulation of nontargeted quantum dots in cultured human embryonic kidney cells

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6096, Issue , 2006, Pages

  Knight, V Bleu ^a   Serrano, Elba E ^a  

^a NEW MEXICO STATE UNIVERSITY   (United States)

Author keywords

Cell culture; Cell viability; Confocal; Endocytosis; Fluorescence; HEK 293; Human astrocytes; Human embryonic kidney; Quantum dots; Semiconductor nanocrystals

Indexed keywords

CELL VIABILITY; CONFOCAL; ENDOCYTOSIS; HEK-293; HUMAN ASTROCYTES; HUMAN EMBRYONIC KIDNEY (HEK); SEMICONDUCTOR NANOCRYSTALS;

BIOMEDICAL ENGINEERING; CELL CULTURE; CELLS; FLUORESCENCE; MEDICAL APPLICATIONS; MICROSCOPIC EXAMINATION; TOXICITY;

SEMICONDUCTOR QUANTUM DOTS;

EID: 33745194612     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.641259     Document Type: Conference Paper

References (28)

1. W.J. Parak, D. Gerion, T. Pellegrino, D. Zanchet, C. Micheel, S.C. Williams, R. Boudreau, M.A. Le Gros, C. A. Larabell, and A.P. Alvisatos, "Biological applications of colloidal nanocrystals," Nanotech. 14, R15-R27, 2003.
2. W.J. Parak, T. Pellegrino, and C. Plank, "Labelling of cells with quantum dots," Nanotech. 16, R9-R25, 2005.
3. P. Alvisatos, "The use of nanocrystals in biological detection," Nature Biotech. 22, 47-52, 2004.
4. X. Gao, S. Nie, "Molecular profiling of single cells and tissue specimens with quantum dots," Trends Biotechnol. 21 (9), 371-3, 2003.
5. J.K. Jaiswal, H. Mattoussi, J.M. Mauro, and S. M. Simon, "Long-term multiple color imaging of live cells using quantum dot bioconjugates," Nature Biotech. 21, 47-52, 2003.
6. B.C. Lagerholm, M. Wang, L.A. Ernst, D.H. Ly, H. Liu, M.P. Bruchez, and A.S. Waggoner, "Multicolor coding of cells with cationic peptide coated quantum dots," Nano Letters 4(10), 2019-2022, 2004.
7. L.C. Mattheakis, J.M. Dias, Y.-J. Choi, J. Gong, M.P. Bruchez, J. Liu, and E. Wang, "Optical coding of mammalian cells using semiconductor quantum dots," Anal. Biochem. 324, 200-208, 2004.
8. K. Hanaki, A. Momo, T. Oku, A. Komoto, S. Maenosono, Y. Yamaguchi, and K. Yamamoto, "Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker," Biochem. and Biophys. Research Comm. 302, 496-501, 2003.
9. M.E. Akerman, W.C.W. Chan, P. Laakkonen, S.N. Bhatia, and E. Tuoslahti, "Nanocrystal targeting in vivo," Proc. Natl. Acad. Sci. 99 (20), 12617-12621, 2002.
10. B. Ballou, B.C. Lagerholm, L.A. Ernst, M.P. Bruchez, and A.S. Waggoner, "Noninvasive imaging of quantum dots in mice," Bioconjugate Chemistry 15, 79-86, 2004.
11. B. Dubertret, P. Skourides, D.J. Norris, V. Noireaux, A.H. Brivanlou, and A. Libchaber, "In vivo imaging of quantum dots encapsulated in phospholipids micelles," Science 298 (29), 1759-1762, 2002.
12. X. Gao, Y. Cui, R.M. Levenson, L.W.K. Chung, and S. Nie, "In vivo cancer targeting and imaging with semiconductor quantum dots," Nature Biotech. 22 (8), 969-976, 2004.
13. D.R. Larson, W.R. Zipfel, R.M Williams, S.W. Clark, M.P. Bruchez, F.W. Wise, and W.W. Webb, "Water-soluble quantum dots for multiphoton fluorescence imaging in vivo," Science 300: 1434-1436, 2003.
14. S.J. Rosenthal, I. Tomlinson, E.M. Adkins, S. Schroeter, S. Adams, L. Swafford, J. McBride, Y. Wang, L.J. DeFelice, and R.D. Blakely, "Targeting cell surface receptors with ligand-conjugated nanocrystals," J Am Chem Soc. 124(17), 4586-94, 2002.
15. E.E. Serrano and V.B. Knight, "Multiphoton imaging of quantum dot bioconjugates in cultured cells following Nd:YLF laser excitation," Nanobiophotonics and Biomedical Applications II, A.N. Cartwright and M. Osiriski, 5705, 225-234, SPIE- The International Society for Optical Engineering, San Jose, 2005.
16. A.M. Derfus, W.C.W. Chan, and S.N. Bhatia, "Probing the cytotoxicity of semiconductor quantum dots", Nano Letters 4(1), 11-18, 2004.
17. Il'yasova, D. and G. G. Schwartz, "Cadmium and renal cancer," Toxicology and Applied Pharmacology 207: 179-186, 2005.
18. Bernard, A, "Renal dysfunction induced by cadmium: biomarkers of critical effects," BioMetals 17: 519-523, 2004.
19. S. Nie and W.C.W. Chan, "Quantum dot bioconjugates for ultrasensitive nonisotopic detection (fluorescent tagging of cell structures)," Science 281(5835), 2016-2019, 1998.
20. J. Silver and W. Ou, "Photoactivation of quantum dot fluorescence following endocytosis," Nano Letters, 5(7), 1445-1449, 2005.
21. I. Mellman, "Endocytosis and molecular sorting," Annu Rev Cell Dev Bio. 12, 575-625, 1996.
22. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, Molecular Biology of the Cell, 739-757, Garland Science, New York, 2002.
23. E. B. Voura, J.K. Jaiswal, H. Mattoussi, and S. M Simon, "Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission scanning microscopy," Nature Medicine 10(9), 993-998, 2004.
24. S. Futaki, S. Goto, T. Suzuki, I Nakase, and Y. Sugiura, "Structural variety of membrane permeable peptides," Curr. Protein Pept. Sci. 4(2), 87-96, 2003.
25. N. Umezawa, M.A. Gelman, M.C. Haigis, R. T. Raines, and S. H Gellman, "Translocation of a beta-peptide across cell membranes," J. Am. Chem. Soc. 124, 360-369, 2001.
26. X. Ronot, A. Doisy, and P. Tracqui, "Quantitative study of dynamic behavior of cell monolayers during in vitro wound healing by optical flow analysis," Cytometry 41, 19-30, 2000.
27. Qtracker 565 cell labeling kit, Quantum Dot Corporation
28. M. Fotin-Mleczek, R. Fischer, and R. Brock, "Endocytosis and cationic cell-penetrating peptides- a merger of concepts and methods," Current Pharmaceutical Design, 11 (28), 3613-3628, 2005.