A novel chitosan CpG nanoparticle regulates cellular and humoral immunity of mice

Biomedical and Environmental Sciences

Volumn 19, Issue 2, 2006, Pages 87-95

  Wu, Kai Yuan ^a   Wu, Mei ^a   Fu, Man Liang ^a   Li, Hui ^a   Yang, Yi ^a   Zhang, Huan ^a   Cheng, Chi ^a   Wang, Ze Zhou ^a   Wang, Xiu Ying ^a   Lü, Xue Bing ^a   Liu, Di Guang ^a   Li, Hua ^a   Gao, Rong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Chitosan nanoparticles; CpG motifs; E. coli; Immune responses; Mouse

Indexed keywords

BACTERIUM ANTIBODY; BIOMATERIAL; CHITOSAN; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN DERIVATIVE; NANOPARTICLE; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; CELLULAR IMMUNITY; CPG ISLAND; ENTEROBACTER INFECTION; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; MOUSE; PATHOGENICITY; SWINE; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; BIOCOMPATIBLE MATERIALS; CHITOSAN; CPG ISLANDS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; IMMUNITY, CELLULAR; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MICE; NANOPARTICLES; OLIGODEOXYRIBONUCLEOTIDES; SWINE; VACCINATION;

ANIMALIA; ESCHERICHIA COLI; SUIDAE; SUS SCROFA;

EID: 33745192606     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Trevor R J, Nicanor O, Robert A G, et al. (1999). Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys. Vaccine 17, 3065-3071.
2. Sato Y M, Roman H, Tighe D, et al. (1996). Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354.
3. Warren H S, Vogel, F R, Chedid L A (1986). Current status of immunological adjuvants. Annu Rev Immunol 4, 369-388.
4. Joachim F, Leander G, Jurgen H, et al. (1999). Effective DNA vaccination against Listeriosis by prime/boost inoculation with the gene gun. J Immunol 163, 4510-4518.
5. Klinman O N, Yamshchikov G, Ishigatsubo Y (1997). Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 158, 3635-3639.
6. Gunther H, Risini D W, Zuhair K B, et al. (2000). Delineation of a CpG sythosphorothioate oligodeonucleotide for activating primate immune responses in vitro and in vivo. J Immunol 164, 1617-1624.
7. Chellat F, Tabrizian M, Dumitriu S, et al. (2000). In vitro and in vivo biocompatibility of chitosan-xanthan polyionic complex. J Biomed Res 51(1), 107-116.
8. Bodmeier R, Chen H G, Paeratakul O (1989). A novel approach to the delivery of micro or nanoparticles. Pharm. Res. 6(5), 413-417.
9. Felt O, Buri P, Gurny, R. (1998). Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm 24, 979-993.
10. Gupta K C, Kumar M N V R (2000). Drug release behavior of beads and microgranules of chitosan. Biomaterials 21, 1115-1119.
11. Mao H Q, Roy K, Troung Le V L, et al. (2001). Chitsan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 70(3), 399-421.
12. Corsi K, Chellat F, Yahia L, et al. (2003). Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials 24(7), 1255-64.
13. Jameela S R, Jayakrishnan A (1995). Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials 16(10), 769-775.
14. Calvo P, Remunan-Lopez C, Vila-Jato J L, et al. (1997). Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res 14(10), 1431-1436.
15. Hirano S (1996). Chitin biotechnology applications. Biotechnol Ann Rev 2, 237-258.
16. J Rhoades, S Roller (2000). Antimicrobial Actions of Degraded and Native Chitosan against Spoilage Organisms in Laboratory. Media and Foods Applied and Environmental Microbiology 66 (10099-2240/0/04), 80-86.
17. Schipper N C, Olsson S, Hoogstraate J A, et al. (1997). Chitosan as absorption enhances for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res 14(7), 923-929.
18. Bodmeier R, Chen H G, Paeratakul O (1989). A novel approach to the delivery of micro or nanoparticles. Pharm Res 6(5), 413-417.
19. Bohle B, Orel L, Kraft D, et al. (2001). Oligodeoxynucleotides containing CpG motifs induce low levels of TFN-α in human B lymphocytes: possible adjuvants for Th1 responses. J Immunol 166, 3743-3748.
20. Shirota H, Sano K, Hirasawa N, et al. (2001). Novel roles of CpG oligodeoxynucleotides as a leader for the samping and presentation of CpG-tagged antigen by dendritic cells. J Immunol 167(1), 66-74.
21. Alcon V L, Foldvari M, Snider M, et al. (2003). Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix). Vaccine 16, 21(17-18), 1811-1814.
22. Mohapatra S S (2003). Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virus. Pediatr Infect Dis J 22(2 Suppl), S100-103.
23. Richardson S C W, Kolbe H J V, Duncan R (1999). Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. International Journal of Pharmaceutics 178(2), 231-243.
24. Mani R, Udgaonkar U, Pawar S (2003). Study of enteropathogenic Escherichia coli (EPEC) diarrhoea in children. Indian J Pathol Microbiol 46(1), 118-120.
25. Amezcua R, Friendship R M, Dewey C E, et al. (2002) Presentation of postweaning Escherichia coli diarrhea in southern Ontario, prevalence of hemolytic E. coli serogroups involved, and their antimicrobial resistance patterns. Can J Vet Res 66(2), 73-78.
26. Bertshinger H U (1999). Post-weaning Escherichia coli diarrhea and edema disease. In Disease of Swine. (Straw B, D'Allaire S, Mengeling W, Taylor D) 8th ed. Ames, Iowa: Iowa State University Press, 441-454.