Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5241-5251

  Shchekotikhin, Andrey E ^a   Glazunova, Valeria A ^b   Luzikov, Yuri N ^a   Buyanov, Vladimir N ^c   Susova, Olga Yu ^b   Shtil, Alexander A ^b   Preobrazhenskaya, Maria N ^a  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c MENDELEEV UNIVERSITY OF CHEMICAL TECHNOLOGY OF RUSSIA   (Russian Federation)

Author keywords

Ametantrone; Cytotoxicity; Drug resistance; Naphthoindolediones; Nucleophilic substitution of methoxy group; P glycoprotein; p53; Tumor cells

Indexed keywords

1 (2 ACETOXYETHYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 1 (2 HYDROXYETHYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 1 METHYL 4,11 BIS[[2 (METHYLAMINO)ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (ACETOXYMETHYL) 1 ACETYL 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (ACETOXYMETHYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 [(DIMETHYLAMINO)METHYL] 4,11 BIS[[2 (METHYLAMINO)ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 ACETYL 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS [[2 (DIMETHYLAMINO)ETHYL]AMINO] 3 [[[2 (DIMETHYLAMINO)ETHYL]AMINO] METHYL] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS(3 PYRROLIDINYLAMINO) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[(2 AMINOETHYL)AMINO] 1 METHYL 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[(2 AMINOETHYL)AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[(2 AMINOETHYL)AMINO] 3 [(DIMETHYLAMINO)METHYL] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[1 (TERT BUTOXYCARBONYL) 3 PYRROLIDINYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 1 (2 HYDROXYETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 1 METHYL 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 3 (HYDROXYMETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 3 (METHOXYMETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 3 [(DIMETHYLAMINO)METHYL] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (DIMETHYLAMINO)ETHYL]AMINO] 3 FORMYL 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 (METHYLAMINO)ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 BIS[[2 [(2HYDROXYETHYL)AMINO]ETHYL]AMINO] 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 DIMETHOXY 3 (HYDROXYMETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 DIMETHOXY 3 (METHOXYMETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; AMETANTRONE; ANTINEOPLASTIC AGENT; DIAMINE DERIVATIVE; DOXORUBICIN; INDOLE DERIVATIVE; TERT BUTYL 3 AMINO 1 PYRROLIDENECARBOXYLATE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESPONSE; DRUG SENSITIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR CELL; WILD TYPE;

CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; INDOLES; K562 CELLS; LEUKEMIA; MOLECULAR STRUCTURE; NAPHTHALENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745174564     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.052     Document Type: Article

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