-
1
-
-
0029587264
-
Toxicokinetics of a single intravenous dose of rac-propranolol versus optically pure propranolol in the rat
-
Bode W, Toet AE, Stolker AA, Van Ginkel LA, Groen K, Wemer J, De Wilt DJ. 1995. Toxicokinetics of a single intravenous dose of rac-propranolol versus optically pure propranolol in the rat. Chirality 7:626-631.
-
(1995)
Chirality
, vol.7
, pp. 626-631
-
-
Bode, W.1
Toet, A.E.2
Stolker, A.A.3
Van Ginkel, L.A.4
Groen, K.5
Wemer, J.6
De Wilt, D.J.7
-
2
-
-
0028220903
-
Stereospecific evaluation of sotalol pharmacokinetics in rat model: Evidence suggesting an enantiomeric interaction
-
Carr RA, Pasutto FM, Foster RT. 1994. Stereospecific evaluation of sotalol pharmacokinetics in rat model: Evidence suggesting an enantiomeric interaction. Biopharmacology and Drug Disposition 15:109-120.
-
(1994)
Biopharmacology and Drug Disposition
, vol.15
, pp. 109-120
-
-
Carr, R.A.1
Pasutto, F.M.2
Foster, R.T.3
-
3
-
-
0027369366
-
Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes
-
Chang TKH, Weber GF, Crespi CL, Waxman DJ. 1993. Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Research 53:5629-5637.
-
(1993)
Cancer Research
, vol.53
, pp. 5629-5637
-
-
Chang, T.K.H.1
Weber, G.F.2
Crespi, C.L.3
Waxman, D.J.4
-
4
-
-
0034913661
-
Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A
-
Desta Z, Soukhova N, Morocho AM, Flackhart DA. 2001. Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A. Journal of Pharmacology and Experimental Therapy 298:508-520.
-
(2001)
Journal of Pharmacology and Experimental Therapy
, vol.298
, pp. 508-520
-
-
Desta, Z.1
Soukhova, N.2
Morocho, A.M.3
Flackhart, D.A.4
-
5
-
-
0023870887
-
Enantiomers of cyclophosphamide and iphosphamide
-
Farmer PB. 1988. Enantiomers of cyclophosphamide and iphosphamide. Biochemistry and Pharmacology 37:145-148.
-
(1988)
Biochemistry and Pharmacology
, vol.37
, pp. 145-148
-
-
Farmer, P.B.1
-
6
-
-
0027487461
-
Stereoselective and isozyme-selective drug interactions
-
Gibaldi M. 1993. Stereoselective and isozyme-selective drug interactions. Chirality 5:407-413.
-
(1993)
Chirality
, vol.5
, pp. 407-413
-
-
Gibaldi, M.1
-
7
-
-
0023035082
-
Dechloroethylation of ifosfamide and neurotoxicity
-
Goren MP, Wright RK, Pratt CB, Pell PE. 1986. Dechloroethylation of ifosfamide and neurotoxicity. Lancet ii:1219-1220.
-
(1986)
Lancet
, vol.2
, pp. 1219-1220
-
-
Goren, M.P.1
Wright, R.K.2
Pratt, C.B.3
Pell, P.E.4
-
8
-
-
0030062783
-
Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients
-
Granvil CP, Ducharme J, Leyland-Joes B, Trudeau M, Wainer IW. 1996. Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients. Cancer Chemotherapy and Pharmacology 37:451-456.
-
(1996)
Cancer Chemotherapy and Pharmacology
, vol.37
, pp. 451-456
-
-
Granvil, C.P.1
Ducharme, J.2
Leyland-Joes, B.3
Trudeau, M.4
Wainer, I.W.5
-
9
-
-
0032946502
-
Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes
-
Granvil CP, Madan A, Sharkawi M, Parkinson A, Wainer IW. 1999. Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metabolism and Disposition 27:533-541.
-
(1999)
Drug Metabolism and Disposition
, vol.27
, pp. 533-541
-
-
Granvil, C.P.1
Madan, A.2
Sharkawi, M.3
Parkinson, A.4
Wainer, I.W.5
-
10
-
-
0024948937
-
Enantioselective aspects of drug action and disposition: Therapeutic pitfalls
-
Jamali F, Mehvar R, Pasutto FM. 1989. Enantioselective aspects of drug action and disposition: Therapeutic pitfalls. Journal of Pharmacology Science 78:695-715.
-
(1989)
Journal of Pharmacology Science
, vol.78
, pp. 695-715
-
-
Jamali, F.1
Mehvar, R.2
Pasutto, F.M.3
-
11
-
-
0025263883
-
Chirality: Clinical pharmacokinetic and pharmacodynamic considerations
-
Lee EJD, Williams KM. 1990. Chirality: Clinical pharmacokinetic and pharmacodynamic considerations. Clinical Pharmacokinetics 18:339-345.
-
(1990)
Clinical Pharmacokinetics
, vol.18
, pp. 339-345
-
-
Lee, E.J.D.1
Williams, K.M.2
-
12
-
-
0031788650
-
Stereoselective steady-state disposition and action of propafenone in Chinese subjects
-
Li G, Gong PL, Qiu J, Zeng FD, Klotz U. 1998. Stereoselective steady-state disposition and action of propafenone in Chinese subjects. British Journal of Clinical Pharmacology 46:441-445.
-
(1998)
British Journal of Clinical Pharmacology
, vol.46
, pp. 441-445
-
-
Li, G.1
Gong, P.L.2
Qiu, J.3
Zeng, F.D.4
Klotz, U.5
-
13
-
-
0031902932
-
Effects of phenobarbital on stereoselective metabolism of ifosfamide in rats
-
Lu H, Wang JJ, Chan KK, Young D. 1998. Effects of phenobarbital on stereoselective metabolism of ifosfamide in rats. Drug Metabolism and Disposition 26:476-482.
-
(1998)
Drug Metabolism and Disposition
, vol.26
, pp. 476-482
-
-
Lu, H.1
Wang, J.J.2
Chan, K.K.3
Young, D.4
-
14
-
-
0029764860
-
Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: The role of plasma protein binding
-
Robinson MA, Mehvar R. 1996. Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: The role of plasma protein binding. Biopharmacology and Drug Disposition 17:577-587.
-
(1996)
Biopharmacology and Drug Disposition
, vol.17
, pp. 577-587
-
-
Robinson, M.A.1
Mehvar, R.2
-
15
-
-
0032708116
-
Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer
-
Roy P, Tretyakov O, Wright J, Waxman DJ. 1999. Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer. Drug Metabolism and Disposition 27:1309-1318.
-
(1999)
Drug Metabolism and Disposition
, vol.27
, pp. 1309-1318
-
-
Roy, P.1
Tretyakov, O.2
Wright, J.3
Waxman, D.J.4
-
16
-
-
0023918663
-
Stereospecific absorption and degradation of cephalexin
-
Tamai I, Ling HY, Timbul SM, Nishikido J, Tsuji A. 1988. Stereospecific absorption and degradation of cephalexin. Journal of Pharmacy and Pharmacology 40:320-324.
-
(1988)
Journal of Pharmacy and Pharmacology
, vol.40
, pp. 320-324
-
-
Tamai, I.1
Ling, H.Y.2
Timbul, S.M.3
Nishikido, J.4
Tsuji, A.5
-
17
-
-
0030071188
-
The N-dechloroethylation of ifosfamide: Using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway
-
Wainer IW, Ducharme J, Granville CP. 1996. The N-dechloroethylation of ifosfamide: Using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway. Cancer Chemotherapy and Pharmacology 37:332-336.
-
(1996)
Cancer Chemotherapy and Pharmacology
, vol.37
, pp. 332-336
-
-
Wainer, I.W.1
Ducharme, J.2
Granville, C.P.3
-
18
-
-
0028354930
-
Ifosfamide stereoselective dechloroethylation and neurotoxicity
-
Wainer IW, Ducharme J, Granvil CP, Trudean M, Leyland-Jones B. 1994b. Ifosfamide stereoselective dechloroethylation and neurotoxicity. Lancet 343:982-983.
-
(1994)
Lancet
, vol.343
, pp. 982-983
-
-
Wainer, I.W.1
Ducharme, J.2
Granvil, C.P.3
Trudean, M.4
Leyland-Jones, B.5
-
19
-
-
0028016175
-
Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model
-
Wainer IW, Granvil CP, Wang T, Batist G. 1994a. Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model. Cancer Research 54:4393-4397.
-
(1994)
Cancer Research
, vol.54
, pp. 4393-4397
-
-
Wainer, I.W.1
Granvil, C.P.2
Wang, T.3
Batist, G.4
-
20
-
-
0028178551
-
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide
-
Walker D, Flinois JP, Monkman SC, Beloc C, Boddy AV, Cholerton S, Daly AK, Lind MJ, Pearson ADJ, Beaune PH, Idle JR. 1994. Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide. Biochemistry and Pharmacology 47:1157-1163.
-
(1994)
Biochemistry and Pharmacology
, vol.47
, pp. 1157-1163
-
-
Walker, D.1
Flinois, J.P.2
Monkman, S.C.3
Beloc, C.4
Boddy, A.V.5
Cholerton, S.6
Daly, A.K.7
Lind, M.J.8
Pearson, A.D.J.9
Beaune, P.H.10
Idle, J.R.11
-
21
-
-
0029012073
-
Identification of new metabolites of ifosfamide in rat urine using ion cluster technique
-
Wang JH, Chan KK. 1995a. Identification of new metabolites of ifosfamide in rat urine using ion cluster technique. Journal of Mass Spectrometry 30:675-683.
-
(1995)
Journal of Mass Spectrometry
, vol.30
, pp. 675-683
-
-
Wang, J.H.1
Chan, K.K.2
-
22
-
-
0029557939
-
3-dechloroethylifosfamide, and iphosphoramide mustard in plasma by gas chromatographic-mass spectrometry
-
3-dechloroethylifosfamide, and iphosphoramide mustard in plasma by gas chromatographic-mass spectrometry. Journal of Chromatography B 674:205-217.
-
(1995)
Journal of Chromatography B
, vol.674
, pp. 205-217
-
-
Wang, J.J.1
Chan, K.K.2
-
23
-
-
0030050920
-
Stereospecific synthesis of tetradeuterated (R)- and (S)-ifosfamide
-
Wang JJ, Chan KK. 1996. Stereospecific synthesis of tetradeuterated (R)- and (S)-ifosfamide. Journal of Labelled Compounds 38:105-115.
-
(1996)
Journal of Labelled Compounds
, vol.38
, pp. 105-115
-
-
Wang, J.J.1
Chan, K.K.2
-
24
-
-
18044401100
-
Stereoselective pharmacokinetics of ifosfamide in male and female rats
-
Wang JJ, Lu H, Chan KK. 2000. Stereoselective pharmacokinetics of ifosfamide in male and female rats. AAPS Pharmscience 2:1-11.
-
(2000)
AAPS Pharmscience
, vol.2
, pp. 1-11
-
-
Wang, J.J.1
Lu, H.2
Chan, K.K.3
-
25
-
-
0027174822
-
Activation of the anti-cancer drug ifosfamide by rat liver microsomal P450 enzymes
-
Weber GF, Waxman DJ. 1993. Activation of the anti-cancer drug ifosfamide by rat liver microsomal P450 enzymes. Biochemistry and Pharmacology 45:1685-1694.
-
(1993)
Biochemistry and Pharmacology
, vol.45
, pp. 1685-1694
-
-
Weber, G.F.1
Waxman, D.J.2
-
26
-
-
0030476592
-
Role of cytochrome P450 in oxazaphosphorine metabolism, Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochrome P450
-
Yu L, Waxman DJ. 1996. Role of cytochrome P450 in oxazaphosphorine metabolism, Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochrome P450. Drug Metabolism and Disposition 24:1254-1262.
-
(1996)
Drug Metabolism and Disposition
, vol.24
, pp. 1254-1262
-
-
Yu, L.1
Waxman, D.J.2
|