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Volumn 14, Issue 15, 2006, Pages 5273-5284
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Synthesis and biological evaluation of novel PDMP analogues
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Author keywords
C C coupling; Glucosylceramide synthase; Inhibitor; PDMP; Sphingolipids
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Indexed keywords
2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL;
4 (HEXADECYLAMINO) 1 PHENYL 5 (PYRROLIDIN 1 YL)PENT 1 EN 3 OL;
4 (HEXADECYLAMINO) 5 MORPHOLINO 1 PHENYLPENT 1 EN 3 OL;
5 AMINO 4 (HEXADECYLAMINO) 1 PHENYLPENT 1 EN 3 OL;
[3 (TERT BUTOXYCARBONYL) 2,2 DIMETHYL 5 (2 PHENYLETHYNYL)OXAZOLIDIN 4 YL]METHYL 4 METHYLBENZENESULFONATE;
[3 (TERT BUTOXYCARBONYL) 5 ETHYNYL 2,2 DIMETHYLOXAZOLIDIN 4 YL]METHYL 4 METHYLBENZENESULFONATE;
N (1 AMINO 3 HYDROXY 5 PHENYLPENT 4 YN 2 YL)PALMITAMIDE;
N (1 AZIDO 3 HYDROXY 5 PHENYLPENT 4 YN 2 YL)PALMITAMIDE;
N (3 HYDROXY 1 MORPHOLINO 5 PHENYLPENT 4 EN 2 YL)PALMITAMIDE;
N (3 HYDROXY 1 MORPHOLINO 5 PHENYLPENT 4 YN 2 YL)PALMITAMIDE;
N [3 HYDROXY 1 (PYRROLIDIN 1 YL)PENT 4 YN 2 YL]PALMITAMIDE;
N [3 HYDROXY 5 PHENYL 1 (PIPERIDIN 1 YL)PENT 4 EN 2 YL]PALMITAMIDE;
N [3 HYDROXY 5 PHENYL 1 (PIPERIDIN 1 YL)PENT 4 YN 2 YL]PALMITAMIDE;
N [3 HYDROXY 5 PHENYL 1 (PYRROLIDIN 1 YL)PENT 4 YN 2 YL]PALMITAMIDE;
TERT BUTYL 1 (TERT BUTYLDIPHENYLSILYLOXY) 3 HYDROXYPENT 4 YN 2 YLCARBAMATE;
TERT BUTYL 1,3 DIHYDROXY 5 PHENYLPENT 4 YN 2 YLCARBAMATE;
TERT BUTYL 1,3 DIHYDROXYPENT 4 YN 2 YLCARBAMATE;
TERT BUTYL 2,2 DIMETHYL 4 (MORPHOLINOMETHYL) 5 (PHENYLETHYNYL)OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 2,2 DIMETHYL 5 (2 PHENYLETHYNYL) 4 [(PIPERIDIN 1 YL)METHYL]OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 2,2 DIMETHYL 5 (2 PHENYLETHYNYL) 4 [(PYRROLIDIN 1 YL)METHYL]OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 3 HYDROXY 1 (TERT BUTYLDIPHENYLSILYLOXY) 5 PHENYLPENT 4 YN 2 YLCARBAMATE;
TERT BUTYL 4 (1' HYDROXY 3' PHENYLPROP 2' YNYL) 2,2 DIMETHYLOXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 4 (1' HYDROXYPROP 2' YNYL) 2,2 DIMETHYLOXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 4 (AZIDOMETHYL) 2,2 DIMETHYL 5 (2 PHENYLETHYNYL)OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 4 (HYDROXYMETHYL) 2,2 DIMETHYL 5 (2 PHENYLETHYNYL)OXAZOLIDINE 3 CARBOXALATE;
TERT BUTYL 4 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 2,2 DIMETHYL 5 (PHENYLETHYNYL)OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 4 [1' HYDROXY 3' (TRIMETHYLSILYL)PROP 2' YNYL] 2,2 DIMETHYLOXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 5 ETHYNYL 2,2 DIMETHYL 4 [(PYRROLIDIN 1 YL)METHYL]OXAZOLIDINE 3 CARBOXYLATE;
TERT BUTYL 5 ETHYNYL 4 [(TERT BUTYLDIPHENYLSILYLOXY)METHYL] 2,3 DIMETHYLOXAZOLIDINE 3 CARBOXYLATE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANIMAL CELL;
ARTICLE;
DRUG POTENCY;
DRUG SCREENING;
DRUG SYNTHESIS;
EMBRYO;
GOLGI COMPLEX;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
NONHUMAN;
RAT;
ANIMALS;
CELL LINE;
CELL PROLIFERATION;
CERCOPITHECUS AETHIOPS;
COS CELLS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG EVALUATION, PRECLINICAL;
ENZYME INHIBITORS;
GLUCOSYLTRANSFERASES;
GOLGI APPARATUS;
HUMANS;
LIVER;
MOLECULAR STRUCTURE;
MORPHOLINES;
RATS;
STRUCTURE-ACTIVITY RELATIONSHIP;
SUBCELLULAR FRACTIONS;
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EID: 33745148689
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2006.03.048 Document Type: Article |
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Times cited : (12)
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References (37)
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