Synthesis of 5-(hydroxymethyl)pyrrolidin-2-ones by cyclization of amide dianions with epibromohydrin

Synthesis

Volumn , Issue 11, 2006, Pages 1807-1810

  Freifeld, Ilia ^a   Armbrust, Holger ^b   Langer, Peter ^c  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Cyclizations; Dianions; Epoxides; Heterocycles; Regioselectivity

Indexed keywords

NEGATIVE IONS; NITROGEN COMPOUNDS; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CYCLIZATIONS; DIANIONS; EPOXIDES; HETEROCYCLES; REGIOSELECTIVITY;

KETONES;

1 (4 ETHOXYPHENYL) 5 HYDROXYMETHYLPYRROLIDIN 2 ONE; 5 HYDROXYMETHYL 1 (3 METHYLPHENYL)PYRROLIDIN 2 ONE; 5 HYDROXYMETHYL 1 (4 METHOXYPHENYL)PYRROLIDIN 2 ONE; 5 HYDROXYMETHYL 1 (4 METHYLPHENYL)PYRROLIDIN 2 ONE; 5 HYDROXYMETHYL 1 PHENYLPYRROLIDIN 2 ONE; AMIDE; ANION; BROMINE DERIVATIVE; EPIBROMOHYDRIN; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; CYCLIZATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 33745140541     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-942354     Document Type: Article

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