Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 1901-1906

  Brouillette, Wayne J ^a   Atigadda, Venkatram R ^a   Ming, Luo ^b   Air, Gillian M ^c   Babu, Yarlagadda S ^d   Bantia, Shanta ^d  

^a Department of Chemistry ^*  (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRROLIDINONE; 4 (N ACETYLAMINO) 3 GUANIDINOBENZOIC ACID; 4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ANTIVIRUS AGENT; BENZOIC ACID; NICOTINYL ALCOHOL; OSELTAMIVIR; SIALIDASE; UNCLASSIFIED DRUG; ZANAMIVIR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; INFLUENZA VIRUS; NONHUMAN; VIRUS INFECTIVITY; VIRUS REPLICATION;

BENZOIC ACID; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NEURAMINIDASE; ORTHOMYXOVIRIDAE; PYRROLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033584149     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00318-2     Document Type: Article

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