In vitro tracheal hyperresponsiveness to muscarinic receptor stimulation by carbachol in a rat model of bleomycin-induced pulmonary fibrosis

Autonomic and Autacoid Pharmacology

Volumn 26, Issue 3, 2006, Pages 327-333

  Barrio, J ^a   Cortijo, J ^a,b   Milara, J ^a   Mata, M ^a   Guijarro, R ^b   Blasco, P ^b   Morcillo, E J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

Airway; Bleomycin; Carbachol; Cytokines; Fibrosis; Hyperresponsiveness; Muscarinic receptor; Trachea

Indexed keywords

BLEOMYCIN; CALCIUM; CARBACHOL; CYTOKINE; FURA 2; INTERLEUKIN 1BETA; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CHOLINERGIC ACTIVITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIFLUORESCENCE MICROSCOPE; EPIFLUORESCENCE MICROSCOPY; EXPERIMENTAL MODEL; IN VITRO STUDY; ISOLATION PROCEDURE; LUNG FIBROSIS; LUNG INJURY; MALE; MEASUREMENT; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; TRACHEA MUSCLE;

ANIMALS; BLEOMYCIN; BRONCHIAL HYPERREACTIVITY; CALCIUM SIGNALING; CARBACHOL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-1; MALE; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745133370     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2006.00378.x     Document Type: Article

References (38)

1. ADNER M. ROSE A.C. ZHANG Y. SWARD K. BENSON M. UDDMAN R. SHANKLEY N.P. CARDELL L.O. ( 2002). An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction. Br. J. Pharmacol., 137, 971 982.
2. AMRANI Y. PANETTIERI R.A. JR. ( 1998). Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists. Thorax, 53, 713 716.
3. AMRANI Y. PANETTIERI R.A. Jr. ( 2002). Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma. Curr. Opin. Allergy Clin. Immunol., 2, 39 45.
4. AMRANI Y. MARTINET N. BRONNER C. ( 1995). Potentiation by tumour necrosis factor-alpha of calcium signals induced by bradykinin and carbachol in human tracheal smooth muscle cells. Br. J. Pharmacol., 114, 4 5.
5. AMRANI Y. PANETTIERI R.A. Jr. FROSSARD N. BRONNER C. ( 1996). Activation of the TNF alpha-p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells. Am. J. Respir. Cell Mol. Biol., 15, 55 63.
6. AMRANI Y. CHEN H. PANETTIERI R.A., Jr. ( 2000). Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma. Respir. Res., 1, 49 53.
7. BARNES P.J. ( 1993). Muscarinic receptor subtypes in airways. Eur. Respir. J., 6, 328 331.
8. BORZONE G. MORENO R. URREA R. MENESES M. OYARZUN M. LISBOA C. ( 2001). Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med., 163, 1648 1653.
9. CAVARRA E. CARRARO F. FINESCHI S. NALDINI A. BARTALESI B. PUCCI A. LUNGARELLA G. ( 2004). Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs. Am. J. Physiol. Lung Cell Mol. Physiol., 287, L1186 L1192.
10. CICALA C. IANARO A. FIORUCCI S. CALIGNANO A. BUCCI M. GERLI R. SANTUCCI L. WALLACE J.L. CIRINO G. ( 2000). NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis. Br. J. Pharmacol., 130, 1399 1405.
11. COOPER J.A. Jr. ( 2000). Pulmonary fibrosis: pathways are slowly coming into light. Am. J. Respir. Cell Mol. Biol., 22, 520 523.
12. CORTIJO J. ESPLUGUES J. MORCILLO E.J. PERPINA M. ( 1984). Pharmacological analysis of the responsiveness of guinea-pig lung parenchymal strip to dopamine. Br. J. Pharmacol., 83, 161 167.
13. CORTIJO J. CERDA-NICOLAS M. SERRANO A. BIOQUE G. ESTRELA J.M. SANTANGELO F. ESTERAS A. LLOMBART-BOSCH A. MORCILLO E.J. ( 2001). Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur. Respir. J., 17, 1228 1235.
14. CORTIJO J. SARRIA B. MATA M. NALINE E. ADVENIER C. MORCILLO E.J. ( 2003). Effects of ouabain on human bronchial muscle in vitro. Naunyn Schmiedeberg's Arch. Pharmacol., 368, 393 403.
15. EGLEN R.M. REDDY H. WATSON N. CHALLISS R.A. ( 1994). Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol. Sci., 15, 114 119.
16. EVANS J.N. KELLEY J. LOW R.B. ADLER K.B. ( 1982). Increased contractility of isolated lung parenchyma in an animal model of pulmonary fibrosis induced by bleomycin. Am. Rev. Respir. Dis., 125, 89 94.
17. GIES J.P. BERTRAND C. VANDERHEYDEN P. WAELDELE F. DUMONT P. PAULI G. LANDRY Y. ( 1989). Characterization of muscarinic receptors in human, guinea pig and rat lung. J. Pharmacol. Exp. Ther., 250, 309 315.
18. GROOTENDORST D.C. RABE K.F. ( 2004). Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc., 1, 77 87.
19. GRYNKIEWICZ G. POENIE M. TSIEN R.Y. ( 1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440 3450.
20. HAKONARSON H. HALAPI E. WHELAN R. GULCHER J. STEFANSSON K. GRUNSTEIN M.M. ( 2001). Association between IL-1beta/TNF-alpha-induced glucocorticoid- sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle. Am. J. Respir. Cell Mol. Biol., 25, 761 771.
21. HAY J. SHAHZEIDI S. LAURENT G. ( 1991). Mechanisms of bleomycin-induced lung damage. Arch. Toxicol., 65, 81 94.
22. KIPS J.C. TAVERNIER J. PAUWELS R.A. ( 1992). Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am. Rev. Respir. Dis., 145, 332 336.
23. KOLB M. MARGETTS P.J. ANTHONY D.C. PITOSSI F. GAULDIE J. ( 2001). Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J. Clin. Invest., 107, 1529 1536.
24. LOU H. DANELISEN I. SINGAL P.K. ( 2004). Cytokines are not upregulated in adriamycin-induced cardiomyopathy and heart failure. J. Mol. Cell Cardiol., 36, 683 690.
25. MORCILLO E.J. PERPINA M. ESPLUGUES J. ( 1984). Hyperresponsiveness to autacoids and autonomic drugs in lung parenchymal strips from sensitized guinea pigs. Am. Rev. Respir. Dis., 129, 948 951.
26. MOZO G. M.L. CARO-PATON A. REYES E. MANZANO L. BELMONTE A. ALMARAZ DEL OLMO A. ALVAREZ-MON M. ( 2004). Pulmonary injuries and cytokine levels after the intraperitoneal administration of pancreatic homogenates in rats. Rev. Esp. Enferm. Dig., 96, 527 533 533-538.
27. NAKATANI Y. NISHIMURA Y. NISHIUMA T. MAEDA H. YOKOYAMA M. ( 2000). Tumor necrosis factor-alpha augments contraction and cytosolic Ca(2+) sensitivity through phospholipase A(2) in bovine tracheal smooth muscle. Eur. J. Pharmacol., 392, 175 182.
28. ORTIZ L.A. CHAMPION H.C. LASKY J.A. GAMBELLI F. GOZAL E. HOYLE G.W. BEASLEY M.B. HYMAN A.L. FRIEDMAN M. KADOWITZ P.J. ( 2002). Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1. Am. J. Physiol. Lung Cell. Mol. Physiol., 282, L1209 L1221.
29. PARRIS J.R. COBBAN H.J. LITTLEJOHN A.F. MACEWAN D.J. NIXON G.F. ( 1999). Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle. J. Physiol., 518, 561 569.
30. PIGUET P.F. ( 1990). Is ''tumor necrosis factor'' the major effector of pulmonary fibrosis. Eur. Cytokine Netw., 1, 257 258.
31. POSTMA D.S. BOEZEN H.M. ( 2004). Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD. Chest, 126, 96S 104S discussion : 159S 161S.
32. RACKE K. MATTHIESEN S. ( 2004). The airway cholinergic system: physiology and pharmacology. Pulm. Pharmacol. Ther., 17, 181 198.
33. RASTOGI D. NGAI P. BARST R.J. KOUMBOURLIS A.C. ( 2004). Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hypertension in children. Pediatr. Pulmonol., 37, 50 55.
34. REYNOLDS A.M. HOLMES M.D. SCICCHITANO R. ( 2000). Cytokines enhance airway smooth muscle contractility in response to acetylcholine and neurokinin A. Respirology, 5, 153 160.
35. SELMAN M. THANNICKAL V.J. PARDO A. ZISMAN D.A. MARTINEZ F.J. LYNCH J.P., III. ( 2004). Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs, 64, 405 430.
36. SERRANO-MOLLAR A. CLOSA D. CORTIJO J. MORCILLO E.J. PRATS N. GIRONELLA M. PANES J. ROSELLO-CATAFAU J. BULBENA O. ( 2002). P-selectin upregulation in bleomycin induced lung injury in rats: effect of N-acetyl-L-cysteine. Thorax, 57, 629 634.
37. SERRANO-MOLLAR A. CLOSA D. PRATS N. BLESA S. MARTINEZ-LOSA M. CORTIJO J. ESTRELA J.M. MORCILLO E.J. BULBENA O. ( 2003). In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br. J. Pharmacol., 138, 1037 1048.
38. SLEIJFER S. ( 2001). Bleomycin-induced pneumonitis. Chest, 120, 617 624.