Design and synthesis of novel sulfonamide-containing bradykinin hB 2 receptor antagonists. 1. Synthesis and SAR of α,α- dimethylglycine sulfonamides

Journal of Medicinal Chemistry

Volumn 49, Issue 12, 2006, Pages 3602-3613

  Fattori, Daniela ^a   Rossi, Cristina ^a   Fincham, Christopher I ^a   Berettoni, Marco ^a   Calvani, Federico ^a   Catrambone, Fernando ^a   Felicetti, Patrizia ^a   Gensini, Martina ^a   Terracciano, Rosa ^a   Altamura, Maria ^a   Bressan, Alessandro ^a   Giuliani, Sandro ^a   Maggi, Carlo A ^a   Meini, Stefania ^a   Valenti, Claudio ^a   Quartara, Laura ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYLQUINOLINE; 3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; ALPHA AMINO ACID; ALPHA,ALPHA DIMETHYLGLYCINE SULFONAMIDE; ANATIBANT; BRADYKININ B2 RECEPTOR ANTAGONIST; DIMETHYLGLYCINE; INOSITOL PHOSPHATE; LEAD; MEN 16132; N [2 [4 [2 AMINO 5 (DIMETHYLAMINO)PENTANOYL]PIPERAZIN 1 YL] 1,1 DIMETHYL 2 OXOETHYL] 2,4 DICHLORO 3 (2,4 DIMETHYLQUINOLIN 8 YLOXYMETHYL)BENZENESULFONAMIDE TRIFLUOROACETATE; N [3 (4 CARBAMIMIDOYLPHENYLAMINO)PROPYL] 2 [2,4 DICHLORO 3 (2,4 DIMETHYLQUINOLIN 8 YLOXYMETHYL)BENZENESULFONYLAMINO] 2 METHYLPROPIONAMIDE TRIFLUOROACETATE; PIPERAZINE DERIVATIVE; QUINOLINE DERIVATIVE; SULFONAMIDE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BIOASSAY; BRONCHOSPASM; CHO CELL; CONTROLLED STUDY; DRUG ACETYLATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; GUINEA PIG; HYPOTENSION; NONHUMAN; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BRADYKININ; BRONCHOCONSTRICTOR AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GUINEA PIGS; HUMANS; HYPOTENSION; INOSITOL PHOSPHATES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; QUINOLINES; RADIOLIGAND ASSAY; RECEPTOR, BRADYKININ B2; SARCOSINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33745125688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060137l     Document Type: Article

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