7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 15, 2006, Pages 3993-3997

  Wu, Biqi ^a   Barrios Sosa, Ana Carolina ^a   Boschelli, Diane H ^a   Boschelli, Frank ^a   Honores, Erick E ^a   Golas, Jennifer M ^a   Powell, Dennis W ^a   Wang, Yanong D ^a  

^a WYETH RESEARCH   (United States)

Author keywords

3 Quinolinecarbonitrile; Src

Indexed keywords

BENZENE DERIVATIVE; DIMETHYLAMINE; NITRILE; PIPERAZINE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDINE; QUINOLINE DERIVATIVE; THIOPHENE; WATER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SUBSTITUTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN;

QUINOLINES; SOLUBILITY; SRC-FAMILY KINASES; WATER;

EID: 33745116626     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.015     Document Type: Article

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30. 50 values represent means of at least two separate determinations.