Extracellular signal-regulated protein kinase is activated in cervical intraepithelial neoplasms but inactivated in invasive cervical carcinoma

Pathology International

Volumn 56, Issue 7, 2006, Pages 368-374

  Matsuura, Keiko ^a   Nohno, Yuka ^a   Hijiya, Naoki ^a   Uchida, Tomohisa ^a   Tsukamoto, Yoshiyuki ^a   Moriyama, Masatsugu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Cervical neoplasms; ERK; Immunohistochemistry; Ki 67

Indexed keywords

ENZYME ANTIBODY; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; AGED; ANTIBODY SPECIFICITY; ARTICLE; BASAL CELL; CANCER CELL; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX EPITHELIUM;

ADULT; AGED; CARCINOMA; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CERVICAL INTRAEPITHELIAL NEOPLASIA; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; PHOSPHORYLATION; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 33745098891     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2006.01973.x     Document Type: Article

References (25)

1. zur Hausen H. Papillomaviruses in human cancers. Proc Assoc Am Physicians 1999 111 : 581 7.
2. Wright TC Jr. Koulos J Schnoll F et al. Cervical intraepithelial neoplasia in women infected with the human immunodeficiency virus: Outcome after loop electrosurgical excision. Gynecol Oncol 1994 55 : 253 8.
3. Zielinski GD Rozendaal L Voorhorst FJ et al. HPV testing can reduce the number of follow-up visits in women treated for cervical intraepithelial neoplasia grade 3. Gynecol Oncol 2003 91 : 67 73.
4. Wallin KL van Doornum GJ Andersson-Ellstrom A et al. Seroepidemiology of human papillomavirus type 73: A sexually transmitted low-risk virus. Int J Cancer 2000 85 : 353 7.
5. Zielinski GD Bais AG Helmerhorst TJ et al. HPV testing and monitoring of women after treatment of CIN 3: Review of the literature and meta-analysis. Obstet Gynecol Surv 2004 59 : 543 53.
6. Bosch FX Lorincz A Munoz N Meijer CJ Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002 55 : 244 65.
7. Seger R Krebs EG. The MAPK signaling cascade. FASEB J 1995 9 : 726 35.
8. Johnson GL Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002 298 : 1911 12.
9. Fang JY Richardson BC. The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005 6 : 322 7.
10. Handra-Luca A Bilal H Bertrand JC Fouret P. Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: Association to aggressive tumor behavior and tumor cell proliferation. Am J Pathol 2003 163 : 957 67.
11. Price DT Rocca GD Guo C Ballo MS Schwinn DA Littrell LM. Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol 1999 162 : 1537 42.
12. Zhuang L Lee CS Scolyer RA et al. Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma. J Clin Pathol 2005 58 : 1163 9.
13. Wright TC Kurman RJ Ferenczy A. Precancerous lesions of the cervix. In : Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract, 4th edn. New York : Springer, 1994 229 78.
14. Liang B Wang S Zhu XG Yu YX Cui ZR Yu YZ. Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. World J Gastroenterol 2005 11 : 623 8.
15. Tsuboi Y Ichida T Sugitani S et al. Overexpression of extracellular signal-regulated protein kinase and its correlation with proliferation in human hepatocellular carcinoma. Liver Int 2004 24 : 432 6.
16. Kurman RJ Noriis HJ Wilkinson E. Tumors of the Cervix, Vagina, and Vulva. Atlas of Tumor Pathology, 3rd Series, Fascicle 4. Washington, DC : Armed Forces Institute of Pathology, 1992 44 73.
17. Alessandrini A. Mek phosphorylation site mutants activate Raf-1 in NIH3T3 cells. J Biol Chem 1996 271 : 31 12 18.
18. Crews CM Alessandrini A Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 1992 258 : 478 80.
19. Steinmetz R Wagoner HA Zeng P et al. Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation. Mol Endocrinol 2004 18 : 2570 82.
20. Persons DL Yazlovitskaya EM Cui W Pelling JC. Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: Inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. Clin Cancer Res 1999 5 : 1007 14.
21. Li DWC Liu JP Mao YW et al. Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by αB-crystallin through inhibition of RAS activation. Mol Biol Cell 2005 16 : 4437 53.
22. Engelbrecht AM Gebhardt S Louw L. Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis. Cancer Lett 2005 235 : 1 7.
23. Payne S Kernohan NM Walker F. Proliferation in the normal cervix and in preinvasive cervical lesions. J Clin Pathol 1996 49 : 667 71.
24. Zanotti S Fisseler-Eckhoff A Mannherz HG. Changes in the topological expression of markers of differentiation and apoptosis in defined stages of human cervical dysplasia and carcinoma. Gynecol Oncol 2003 89 : 376 84.
25. Natale P Luciani L. [Our results in the treatment of cancer of the uterine cervix as compared with the world statistics published in the 'Annual Report' of Stockholm]. Minerva Ginecol 1968 20 : 180 85.