Changes in the topological expression of markers of differentiation and apoptosis in defined stages of human cervical dysplasia and carcinoma

Gynecologic Oncology

Volumn 89, Issue 3, 2003, Pages 376-384

  Zanotti, Silvia ^a   Fisseler Eckhoff, Annette ^a,b   Mannherz, Hans Georg ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Institute of Pathology and Cythology   (Germany)

Author keywords

Apoptosis; Bcl 2; Cervical carcinoma; Deoxyribonuclease; Mad 1

Indexed keywords

CASPASE 3; DEOXYRIBONUCLEASE I; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN MAD1;

APOPTOSIS; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER LOCALIZATION; CANCER STAGING; CARCINOMA IN SITU; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NICK END LABELING; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS EPITHELIUM; SUPERFICIAL CANCER; TISSUE SECTION; TUMOR CELL; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CONIZATION; UTERINE CERVIX EPITHELIUM; UTERUS CARCINOMA;

EID: 0037565072     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-8258(03)00061-1     Document Type: Article

References (55)

1. Richart R.M., Lerch V. Time-lapse cinematographic observations of normal human cervical, dysplasia, and carcinoma in situ. J Natl Cancer Inst. 37:1996;317-329.
2. Fu Y.S., Reagan J., Richart R.M. Definition of precursors. Gynecol Oncol. 12:1981;220-231.
3. Pieters W.J., Koudstaal J., Ploem-Zaajer J.J., Janssens J., Oosterhuis J.W. The three group metaphase as morphologic indicator of high ploidy cells in cervical intraepithelial neoplasia. Anal Quant Cytol Histol. 14:1992;227-232.
4. Richart R.M. Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynecol. 10:1968;748-784.
5. Wright T.C., Ferenczy A., Kurman R.J. Carcinoma and other tumors of the cervix. Kurman R.J. Blaustein's pathology of the female genital tract. 4th ed: 1994;279-326 Springer-Verlag, New York.
6. Fidler H.K., Boyes D.A., Worth A.J. Cervical cancer detection in British Columbia. A progress report. J Obstet Gynaecol Br Commonw. 75:1968;392-404.
7. Spriggs A.I., Boddington M.M. Progression and regression of cervical lesions review of smears from women followed without initial biopsy or treatment . J Clin Pathol. 33:1980;517-525.
8. Kerr J.F.R., Wyllie A.H., Currie A.R. Apoptosis a basic biological phenomenon with wide-ranging implications in tissue kinetics . Br J Cancer. 26:1972;239-257.
9. Cohen J.J. Apoptosis. Immunol Today. 14:1993;126-130.
10. Fesus L., Davies P.J.A., Piacentini M. Apoptosis molecular mechanisms in programmed cell death . Eur J Cell Biol. 56:1991;170-177.
11. Hale A.J., Smith C.A., Sutherland L.C., Stoneman V.E., Longthorne V.L., Culhane A.C., Williams G.T. Apoptosis molecular regulation of cell death . Eur J Biochem. 236:1996;1-26.
12. Wyllie A.H., Kerr J.F.R., Currie A.R. Cell death the significance of apoptosis . Int Rev Cytol. 68:1980;251-306.
13. Green D., Kroemer G. The central executioners of apoptosis caspases or mitochondria? Trends Cell Biol. 8:1998;267-271.
14. Peitsch M.C., Mannherz H.G., Tschopp J. The apoptosis endonucleases cleaning up after cell death . Trends Cell Biol. 4:1994;37-41.
15. Walker P.R., Sikorska M. New aspects of the mechanism of DNA fragmentation in apoptosis. Biochem Cell Biol. 75:1997;287-299.
16. Enari M., Sakahira H., Yoloyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1997;43-50.
17. Peitsch M.C., Polzar B., Stephan H., Crompton T., McDonald H.R., Mannherz H.G., Tschopp J. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12:1993;371-377.
18. McIllroy D., Tanak M., Sakahira H., Fukuyama H., Suzuki M., Yamamura K., Ohsawa Y., Uchiyama Y., Nagata S. An auxillary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev. 14:2000;549-558.
19. Napirei M., Karsunky H., Zevnik B., Stephan H., Mannherz H.G., Möröy T. Features of systemic lupus erythematosus (SLE) in Dnase 1 deficient mice. Nat Genet. 25:2000;177-181.
20. Mukae K., Enari M., Sakahira H., Fukuda Y., Inazawa J., Toh H., Nagata S. Molecular cloning and characterizytion of human caspase-activated DNase. Proc Natl Acad Sci USA. 95:1998;9123-9128.
21. Shiokawa D., Ohyama H., Yamada T., Takahashi K., Tanuma S. Identification of an endonuclease responsible for apoptosis in rat thymocytes. Eur J Biochem. 226:1994;23-30.
22. Shiokawa D., Tanuma S. Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase γ Biochem J. 332:1998;713-720.
23. Liu Q.Y., Pandey S., Singh R.K., Lin W., Ribecco M., Borowy-Borowski H., Smith B., LeBlanc J., Walker R., Sikorska M. DNaseY a rat DNase I-like gene coding for a constitutively expressed chromatin-bound endonuclease . Biochemistry. 37:1998;10134-10143.
24. Kreuder V., Dieckhoff J., Sittig M., Mannherz H.G. Isolation, characterisation and crystallization of deoxyribonuclease I from bovine and rat parotid gland and its interaction with rabbit skeletal muscle actin. Eur J Biochem. 139:1984;389-400.
25. Polzar B., Rösch A., Mannherz H.G. A simple procedure to produce monospecific polyclonal antibodies of high affinity against actin from muscular sources. Eur J Cell Biol. 50:1989;220-229.
26. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol. 119:1992;493-501.
27. Wijsman J.H., Jonker R.R., Keijzer R., van de Velde J.H., Cornelisse C.J., van Dierendonck J.H. A new method to detect apoptosis in paraffin sections in situ end-labelling of fragmented DNA . J Histochem Cytochem. 41:1993;7-12.
28. Polzar B., Mannherz H.G. Nucleotide sequence of a full length cDNA clone encoding the deoxyribonuclease I from rat parotid gland. Nucleic Acid Res. 18:1990;7151.
29. Zanotti S., Polzar B., Stephan H., Doll U., Niessing J., Mannherz H.G. Localization of deoxyribonuclease I gene transcripts and protein in rat tissues and its correlation with apoptotic cell elimination. Histochemistry. 103:1995;369-377.
30. Stephan H., Polzar B., Rauch F., Zanotti S., Ulke C., Mannherz H.G. Distribution of deoxyribonuclease I (DNase I) and p53 in rat testis and their correlation with apoptosis. Histochem Cell Biol. 106:1996;383-393.
31. Rauch F., Polzar B., Stephan H., Zanotti S., Paddenberg R., Mannherz H.G. Androgen ablation leads to an upregulation and intranuclear accumulation of deoxyribonuclease I in rat prostate epithelial cells paralleling their apoptotic elimination. J Cell Biol. 137:1997;909-923.
32. Isacson C., Kessis T.D., Hedrick L., Cho K.R. Both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type. Cancer Res. 56:1996;669-674.
33. Hurlin P.J., Foley K.P., Ayer D.E., Eisenman R.N., Hanahan D., Arbeit J.M. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorgenesis. Oncogene. 11:1995;2487-2501.
34. zur Hausen H. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology. 184:1991;9-13.
35. Crum C.P., Mitao M., Levine R.U., Silverstein S. Cervical papillomaviruses segregate within morphologically distinct precancerous lesions. J Virol. 54:1985;675-681.
36. Bergeron C., Barrasso R., Beaudenon S., Flamant P., Croissant O., Orth G. Human papillomaviruses associated with cervical intraepithelial neoplasia. Great diversity and distinct distribution in low- and high-grade lesions. Am J Surg Pathol 1. 6:1992;641-649.
37. Cooper K., McGee J.O.D. Human papillomavirus, integration and cervical carcinogenesis a clinicopathological perspective . J Clin Pathol. 50:1996;1-3.
38. Hubbert N.L., Sedman S.A., Schiller J.T. Human papillomavirus type 16 E6 increases the degradation rate of p53 win human keratinocytes. J Virol. 66:1992;6237-6241.
39. Dyson N., Howley P.M., Munger K., Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 243:1989;934-937.
40. Ferenczy A., Wright T.C. Anatomy and histology of the cervix. Kurman R.J. Blaustein's pathology of the female genital tract. 4th ed: 1994;185-201 Springer-Verlag, New York.
41. Al-Saleh W., Delvenne P., Greimers R., Fridman V., Doyen J., Boniver J. Assessment of Ki-67 antigen immunostaining in squamous intraepithelial lesions of the uterine cervix. Am J Clin Pathol. 104:1995;154-160.
42. Payne S., Kernohan N.M., Walker F. Proliferation in the normal cervix and in preinvasive cervical lesions. Clin Pathol. 49:1996;667-671.
43. Heatley M.K. Proliferation in the normal cervix and in preinvasive cervical lesions. J Clin Pathol. 49:1996;957.
44. INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 92:2001;276-284.
45. Davidson B., Goldberg I., Lerner-Geva L., Gotlieb W.H., Ben-Baruch G., Novikov I., Kopolovic J. Expression of topoisomerase II and Ki67 in cervical carcinoma - clinopathological study using immunohistochemistry. APMIS. 108:2000;209-215.
46. Shoji Y., Saegusa M., Takano Y., Ohbu M., Okayasu I. Correlation of apoptosis with tumour cell differentiation, progression and HPV infection in cervical carcinoma. J Clin Pathol. 49:1996;134-138.
47. Bohlinger I., Leist M., Gantner F., Angermüller S., Tiegs G., Wendel A. DNA fragmentation in mouse organs during endotoxic shock. Am J Pathol. 149:1996;1381-1393.
48. Saegusa M., Takano Y., Hashimura M., Shoji Y., Okayasu I. The possible role of bcl-2 expression in the progression of tumors of the uterine cervix. Cancer. 76:1995;2297-2303.
49. Nakamura T., Nomura S., Sakai T., Nariya S. Expression of bcl-2 oncoprotein in gastrointestinal and uterine carcinomas and their premalignant lesions. Hum Pathol. 28:1997;309-315.
50. Ter Harmsel B., Smedts F., Kuijpers J., Jeunink M., Trimbos B., Ramaekers F. Bcl-2 immunoreactivity increases with severity of CIN a study of normal cervical epithelia, CIN and cervical carcinoma . J Pathol. 179:1996;26-30.
51. Tjalma W., De Cuyper E., Weyler J., van Marck E., de Pooter C., van Dam P. Expression of bcl-2 expression in invasive and in situ carcinoma of the uterine cervix. Am J Obstet Gynecol. 178:1998;113-117.
52. Los M., Stroh C., Jänicke R.U., Engels I.C.H., Schulze-Osthoff K. Caspases more than just killers? Trends Immunol. 22:2001;31-34.
53. Cheung T.-H., Chung T.K.-H., Lo K.W.-K., Yu M.-Y., Krajewski S., Reed J.C., Wong Y.-F. Apoptosis related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix. Gynecol Oncol. 86:2002;14-18.
54. von Kobyletzki G., Heine O., Stephan H., Pieck C., Stücker M., Hoffmann K., Altmeyer P., Mannherz H.G. UVA1 irradiation induces apoptosis in cutaneous T-cell lymphoma in vivo. Photodermatol Photoimmunol Photomed. 16:2000;271-277.
55. Liu B., Peng D., Lu Y., Jin W., Fan Z. A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity. J Biol Chem. 277:2002;30159-30164.