The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa

Ophthalmic Genetics

Volumn 27, Issue 2, 2006, Pages 39-41

  Fingert, John H ^a   Kwon, Young H ^a   Moore, Paula A ^a   Johnston, Rebecca M ^a   Kim, Kwang Youn ^a   Sheffield, Val C ^a,b   Alward, Wallace L M ^a   Stone, Edwin M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Genetics; Glaucoma; Methylenetetrahydrofolate reductase; MTHFR; Mutation

Indexed keywords

METHYLENETETRAHYDROFOLATE DEHYDROGENASE;

ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC VARIABILITY; GENOTYPE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; OPEN ANGLE GLAUCOMA; POPULATION GENETICS; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; PSEUDOEXFOLIATION; PSEUDOEXFOLIATION GLAUCOMA; STATISTICAL ANALYSIS; UNITED STATES;

ADULT; EXFOLIATION SYNDROME; GENE AMPLIFICATION; GENE FREQUENCY; GENOTYPE; GLAUCOMA, OPEN-ANGLE; HUMANS; HYPERHOMOCYSTEINEMIA; INTRAOCULAR PRESSURE; IOWA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMERASE CHAIN REACTION; VARIATION (GENETICS);

EID: 33745095042     PISSN: 13816810     EISSN: 17445094     Source Type: Journal    
DOI: 10.1080/13816810600677883     Document Type: Article

References (13)

1. Bleich S, Junemann A, Von Ahsen N, et al. Homocysteine and risk of open-angle glaucoma. J Neural Transm. 2002;109(12):1499-1504.
2. Bleich S, Kornhuber J, Junemann AG. Homocysteine in primary and secondary open-angle glaucoma. J Glaucoma. 2003;12(6):498-499; author reply 499.
3. Leibovitch I, Kurtz S, Shemesh G, et al. Hyperhomocystinemia in pseudoexfoliation glaucoma. J Glaucoma. 2003;12(1):36-39.
4. Bleich S, Roedl J, Von Ahsen N, et al. Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma. Am J Ophthalmol. 2004;138(1):162-164.
5. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338(15):1042-1050.
6. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
7. Moore P, El-Sherbeny A, Roon P, et al. Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. Exp Eye Res. 2001;73:45-57.
8. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111-113.
9. de Bree A, Verschuren WM, Blom HJ, Kromhout D. Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am J Epidemiol. 2001;154(2):150-154.
10. Jünemann AGM, Von Ahsen N, Reulbach U, et al. C677T variant in the methylenetetrahydrofolate reductase gene is a genetic risk factor for primary open angle glaucoma. Am J Ophthalmol. 2005;139:721-723.
11. Turacli ME, Tekeli O, Ozdemir F, Akar N. Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation. Clin Exp Ophthalmol. 2005;33:505-508.
12. Alward WL, Fingert JH, Coote MA, et al. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A) [see comments]. N Engl J Med. 1998;338(15):1022-1027.
13. Bassam BJ, Caetano-Anolles G, Gresshoff PM. Fast and sensitive silver staining of DNA in polyacrylamide gels. Anal Biochem. 1991;196(1):80-83.