Role of calcium and other trace elements in the gastrointestinal physiology

World Journal of Gastroenterology

Volumn 12, Issue 20, 2006, Pages 3229-3236

  Kirchhoff, P ^a   Geibel, John P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Gastrointestinal physiology; Trace elements

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; CHLORIDE; GASTRIN; TRACE ELEMENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; COLON CANCER; DIGESTIVE FUNCTION; EPITHELIUM CELL; GASTRIN CELL; GASTROINTESTINAL TRACT; HUMAN; INTESTINE EPITHELIUM; MOLECULAR MECHANICS; NONHUMAN; REGULATORY MECHANISM; STOMACH ACID SECRETION;

EID: 33745080585     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i20.3229     Document Type: Article

References (96)

1. Nearing J, Betka M, Quinn S, Hentschel H, Elger M, Baum M, Bai M, Chattopadyhay N, Brown EM, Hebert SC, Harris HW. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Proc Natl Acad Sci USA 2002; 99: 9231-9236
2. Diaz R, Hurwitz S, Chattopadhyay N, Pines M, Yang Y, Kifor O, Einat MS, Butters R, Hebert SC, Brown EM. Cloning, expression, and tissue localization of the calcium-sensing receptor in chicken (Gallus domesticus). Am J Physiol 1997; 273: R1008-1016
3. Cima RR, Cheng I, Klingensmith ME, Chattopadhyay N, Kifor O, Hebert SC, Brown EM, Soybel DI. Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa. Am J Physiol 1997; 273: G1051-1060
4. Caroppo R, Gerbino A, Debellis L, Kifor O, Soybel DI, Brown EM, Hofer AM, Curci S. Asymmetrical, agonist-induced fluctuations in local extracellular [Ca(2+)] in intact polarized epithelia. EMBO J 2001; 20: 6316-6326
5. Cheng SX, Okuda M, Hall AE, Geibel JP, Hebert SC. Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. Am J Physiol Gastrointest Liver Physiol 2002; 283: G240-250
6. Cheng I, Qureshi I, Chattopadhyay N, Qureshi A, Butters RR, Hall AE, Cima RR, Rogers KV, Hebert SC, Geibel JP, Brown EM, Soybel DL. Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology 1999; 116: 118-126
7. Chattopadhyay N, Cheng I, Rogers K, Riccardi D, Hall A, Diaz R, Hebert SC, Soybel DI Brown EM. Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine. Am J Physiol 1998; 274: G122-130
8. Gama L, Baxendale-Cox LM, Breitwieser GE. Ca2+-sensing receptors in intestinal epithelium. Am J Physiol 1997; 273: C1168-1175
9. Mitsuma T, Rhue N, Kayama M, Mori Y, Adachi K, Yokoi Y, Ping J, Nogimori T, Hirooka Y. Distribution of calcium sensing receptor in rats: an immunohistochemical study. Endocr Regul 1999; 33: 55-59
10. Butters RR Jr, Chattopadhyay N, Nielsen P, Smith CP, Mithal A, Kifor O, Bai M, Quinn S, Goldsmith P, Hurwitz S, Krapcho K, Busby J, Brown EM. Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium. J Bone Miner Res 1997; 12: 568-579
11. Rutten MJ, Bacon KD, Marlink KL, Stoney M, Meichsner CL, Lee FP, Hobson SA, Rodland KD, Sheppard BC, Trunkey DD, Deveney KE, Deveney CW. Identification of a functional Ca2+- sensing receptor in normal human gastric mucous epithelial cells. Am J Physiol 1999; 277: G662-670
12. Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochernical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem 2000; 48: 595-602
13. Hentschel H, Nearing L Harris HW, Betka M, Baum M, Hebert SC, Elger M. Localization of Mg2+-sensing shark kidney calcium receptor SKCaR in kidney of spiny dogfish, Squalus acand-das. Am J Physiol Renal Physiol 2003; 285: F430-439
14. Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003; 63: 67-71
15. Kallay E, Bajna E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Dietary calcium and growth modulation of human colon cancer cells: role of the extracellular calcium-sensing receptor. Cancer Detect Prev 2000; 24: 127-136
16. Buchan AM, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 2001; 120: 1128-1139
17. Ray JM, Squires PE, Curtis SB, Meloche MR, Buchan AM. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 1997; 99: 2328-2333
18. Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. J Biol Chem 2001; 276: 39549-39552
19. Hirschowitz BI, Keeling D, Lewin M, Okabe S, Parsons M, Sewing K, Wallmark B, Sachs G. Pharmacological aspects of acid secretion. Dig Dis Sci 1995; 40: S3-23
20. Prinz C, Kajimura M, Scott D, Helander H, Shin J, Besancon M, Bamberg K, Hersey S, Sachs G. Acid secretion and the HK ATPase of stomach. Yale J Biol Med 1992; 65: 577-596
21. Hersey SJ, Sachs G. Gastric acid secretion. Physiol Rev 1995; 75: 155-189
22. Sachs G, Prinz C, Loo D, Bamberg K, Besancon M, Shin JM. Gastric acid secretion: activation and inhibition. Yale J Biol Med 1994; 67: 81-95
23. Scott DR, Helander HF, Hersey SJ, Sachs G. The site of acid secretion in the mammalian parietal cell. Biochim Biophys Acta 1993; 1146: 73-80
24. Gedda K, Scott D, Besancon M, Lorentzon P, Sachs G. Turnover of the gastric H+,K(+)-adenosine triphosphatase alpha subunit and its effect on inhibition of rat gastric acid secretion. Gastroenterology 1995; 109: 1134-1141
25. Forte JG, Adams PH, Davies RE. Acid secretion and phosphate metabolism in bullfrog gastric mucosa. Biochim Biophys Acta 1965; 104: 25-38
26. Forte JG. Recent concepts of the mechanism of hydrochloric acid secretion. J Indian Med Prof 1966; 12: 5637-5647
27. Rong Q, Bastaki SM, Forte JG. An improved method to evaluate secretory activity of isolated gastric glands and cells. Dig Dis Sci 2002; 47: 1001-1007
28. Yamaji R, Sakamoto M, Miyatake K, Nakano Y. Hypoxia inhibits gastric emptying and gastric acid secretion in conscious rats. J Nutr 1996; 126: 673-680
29. Sachs G, Shin JM, Besancon M, Prinz C. The continuing development of gastric acid pump inhibitors. Aliment Pharmacol Ther 1993; 7 Suppl 1: 4-12, discussion 29-31
30. Cuppoletti J, Sachs G. Regulation of gastric acid secretion via modulation of a chloride conductance. J Biol Chem 1984; 259: 14952-14959
31. Malinowska DH, Cuppoletti J, Sachs G. Cl- requirement of acid secretion in isolated gastric glands. Am J Physiol 1983; 245: G573-581
32. Banerjee S, El-Omar E, Mowat A, Ardill JE, Park RH, Watson W, Beattie AD, McColl KE. Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer. Gastroenterology 1996; 110: 717-724
33. Geibel J, Abraham R, Modlin I, Sachs G. Gastrin-stimulated changes in Ca2+ concentration in parietal cells depends on adenosine 3′,5′ -cyclic monophosphate levels. Gastroenterology 1995; 109: 1060-1067
34. Urushidani T, Forte JG. Signal transduction and activation of acid secretion in the parietal cell. J Membr Biol 1997; 159: 99-111
35. Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol 2005; 289: G664-669
36. Dufner MM, Kirchhoff P, Remy C, Hafner P, Muller MK, Cheng SX, Tang LQ, Hebert SC, Geibel JP, Wagner CA. The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands. Am J Physiol Gastrointest Liver Physiol 2005; 289: G1084-1090
37. Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J. Expression of the calcium- sensing receptor in gastrinomas. J Clin Endocrinol Metab 2000; 85: 4131-4137
38. Itami A, Kato M, Komoto I, Doi R, Hosotard R, Shimada Y, Imamura M. Human gastrinoma cells express calcium-sensing receptor. Life Sci 2001; 70: 119-129
39. Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 2002; 82: 245-289
40. Raufman JP. Cholera. Am J Med 1998; 104: 386-394
41. Sandle GI. Salt and water absorption in the human colon: a modem appraisal. Gut 1998; 43: 294-299
42. Binder HJ, Singh SK, Geibel JP, Rajendran VM. Novel transport properties of colonic crypt cells: fluid absorption and Cl-dependent Na-H exchange. Comp Biochem Physiol A Physiol 1997; 118: 265-269
43. Favus MJ, Kathpalia SC, Coe FL. Kinetic characteristics of calcium absorption and secretion by rat colon. Am J Physiol 1981; 240: G350-354
44. Lee DB, Walling MW, Gafter U, Silis V, Coburn JW. Calcium and inorganic phosphate transport in rat colon: dissociated response to 1,25-dihydroxyvitamin D3. J Clin Invest 1980; 65: 1326-1331
45. Nellans HN, Kimberg DV. Anomalous calcium secretion in rat ileum: role of paracellular pathway. Am J Physiol 1979; 236: E473-481
46. Cheng SX, Geibel JP, Hebert SC. Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Gastroenterology 2004; 126: 148-158
47. Singh SK, Binder HJ, Boron WF, Geibel JP. Fluid absorption in isolated perfused colonic crypts. J Clin Invest 1995; 96: 2373-2379
48. de Jesus Ferreira MC, Helies-Toussaint C, Imbert-Teboul M, Bailly C, Verbavatz JM, Bellanger AC, Chabardes D. Co- expression of a Ca2+-inhibitable adenylyl cyclase and of a Ca2+-sensing receptor in the cortical thick ascending limb cell of the rat kidney. Inhibition of hormone-dependent cAMP accumulation by extracellular Ca2+. J Biol Chem 1998; 273: 15192-15202
49. De Jesus Ferreira MC, Bailly C. Extracellular Ca2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol 1998; 275: F198-203
50. Oda Y, Tu CL, Chang W, Crurnrine D, Komuves L, Mauro T, Elias PM, Bikle DD. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem 2000; 275: 1183-1190
51. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem 1998; 273: 23344-23352
52. Tu CL, Oda Y, Bilde DD. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes. J Invest Dermatol 1999; 113: 340-345
53. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest 1996; 97: 1085-1093
54. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 2001; 177: 161-171
55. Mailland M, Waelchli R, Ruat M, Boddeke HG, Seuwen K. Stimulation of cell proliferation by calcium and a calcimimetic compound. Endocrinology 1997; 138: 3601-3605
56. Lin KI, Chattopadhyay N, Bai M, Alvarez R, Dang CV, Baraban JM, Brown EM, Ratan RR. Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochem Biophys Res Commun 1998; 249: 325-331
57. McNeil SE, Hobson SA, Nipper V, Rodland KD. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J Biol Chem 1998; 273: 1114-1120
58. Quinn SJ, Ye CP, Diaz R, Kifor O, Bai M, Vassilev P, Brown E. The Ca2+-sensing receptor: a target for polyamines. Am J Physiol 1997; 273: C1315-1323
59. Conigrave AD, Quinn SJ, Brown EM. L-amino acid sensing by the extracellular Ca2+-sensing receptor. Proc Natl Acad Sci USA 2000; 97: 4814-4819
60. Conigrave AD, Franks AH, Brown EM, Quinn SJ. L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? Eur J Clin Nutr 2002; 56: 1072-1080
61. Buts JP, De Keyser N, Kolanowski J, Sokal E, Van Hoof F. Maturation of villus and crypt cell functions in rat small intestine. Role of dietary polymines. Dig Dis Sci 1993; 38: 1091-1098
62. Loser C, Eisel A, Harms D, Folsch UR. Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. Gut 1999; 44: 12-16
63. Dufour C, Dandrifosse G, Forget P, Vermesse F, Romain N, Lepoint P. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology 1988; 95: 112-116
64. Bardocz S, Duguid TJ, Brown DS, Grant G, Pusztai A, White A, Ralph A. The importance of dietary polyamines in cell regeneration and growth. Br J Nutr 1995; 73: 819-828
65. Osborne DL, Seidel ER. Microflora-derived polyamines modulate obstruction-induced colonic mucosal hypertrophy. Am J Physiol 1989; 256: G1049-1057
66. Seiler N, Delcros JG, Moulinoux JP. Polyamine transport in mammalian cells. An update. Int J Biochem Cell Biol 1996; 28: 843-861
67. Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res 1988; 48: 759-774
68. Marton LJ, Pegg AE. Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol 1995; 35: 55-91
69. Pegg AE, McCann PP. Polyamine metabolism and function. Am J Physiol 1982; 243: C212-221
70. Van Aken E, De Wever O, Correia da Rocha AS, Mareel M. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch 2001; 439: 725-751
71. Wong NA, Pignatelli M. Beta-catenin--a linchpin in colorectal carcinogenesis? Am J Pathol 2002; 160: 389-401
72. Kallay E, Kifor O, Chattopadhyay N, Brown EM, Bischof MG, Peterlik M, Cross HS. Calcium-dependent c-myc proto- oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor. Biochem Biophys Res Commun 1997; 232: 80-83
73. Yamaguchi T, Chattopadhyay N, Kifor O, Sanders JL, Brown EM. Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochem Biophys Res Commun 2000; 279: 363-368
74. Yamaguchi T, Chattopadhyay N, Kifor O, Butters RR Jr, Sugimoto T, Brown EM. Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)- sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. J Bone Miner Res 1998; 13: 1530-1538
75. Yamaguchi T, Yamauchi M, Sugimoto T, Chauhan D, Anderson KC, Brown EM, Chihara K. The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation. Biochem Biophys Res Commun 2002; 299: 532-538
76. Hobson SA, McNeil SE, Lee F, Rodland KD. Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells. Exp Cell Res 2000; 258: 1-11
77. Kifor O, MacLeod RJ, Diaz R, Bai M, Yamaguchi T, Yao T, Kifor I, Brown EM. Regulation of MAP kinase by calcium- sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am J Physiol Renal Physiol 2001; 280: F291-F302
78. Bresalier RS. Calcium, chemoprevention, and cancer: a small Step forward (a long way to go). Gastroenterology 1999; 116: 1261-1263
79. Lamprecht SA, Lipkin M. Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal. carcinogenesis. Ann N Y Acad Sci 2001; 952: 73-87
80. Kifor O, MacLeod RJ, Diaz R, Bai M, Yamaguchi T, Yao T, Kifor I, Brown EM. Regulation of MAP kinase by calcium- sensing receptor in bovine parathyroid and CaR.-transfected HEK293 cells. Am J Physiol Renal Physiol 2001; 280: F291-302
81. Rozen P, Lubin F, Papo N, Knaani J, Farbstein H, Farbstein M, Zajicek G. Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma. patients. Cancer 2001; 91: 833-840
82. Holt PR, Atillasoy EO, Gilman J, Guss J, Moss SF, Newmark H, Fan K, Yang K, Lipkin M. Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized controlled trial. JAMA 1998; 280: 1074-1079
83. Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1985; 1: 307-309
84. Holt PR, Atillasoy EO, Gilman J, Guss J, Moss SF, Newmark H, Fan K, Yang K, Lipkin M. Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized controlled trial. JAMA 1998; 280: 1074-1079
85. Holt PR, Lipkin M, Newmark H. Calcium intake and colon Cancer biomarkers. JAMA 1999; 281: 1172-1173
86. Ahnen DJ, Byers T. Proliferation happens. JAMA 1998; 280: 1095-1096
87. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Bond JH, Greenberg ER. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 1999; 340:101-107
88. Lipkin M, Newmark H. Calcium and the prevention of colon cancer. J Cell Biochem Suppl 1995; 22: 65-73
89. Slattery ML, Sorenson AW, Ford MH. Dietary calcium intake as a mitigating factor in colon cancer. Am J Epidemiol 1988; 128: 504-514
90. Duris I, Hruby D, Pekarkova B, Huorka M, Cernakova E, Bezayova T, Ondrejka P. Calcium chemoprevention in colorectal cancer. Hepatogastroenterology 1996; 43: 152-154
91. Pence BC. Role of calcium in colon cancer prevention: experimental and clinical studies. Mutat Res 1993; 290: 87-95
92. Lipkin M, Newmark H. Development of clinical chemoprevention trials. J Natl Cancer Inst 1995; 87: 1275-1277
93. Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. Am J Clin Nutr 2003; 78: S584-592
94. Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption. Am J Clin Nutr 1998; 68: 859-865
95. Kerstetter JE, Svastisalee CM, Caseria DM, Mitnick ME, Insogna KL. A threshold for low-protein-diet-induced elevations in parathyroid hormone. Am J Clin Nutr 2000; 72: 168-173
96. Heaney RP. Dietary protein and phosphorus do not affect calcium absorption. Am J Clin Nutr 2000; 72: 758-761