Feedback regulation of SREBP and aromatase in A β(25-35)-supplemented human neuroblastoma cells

Cellular and Molecular Neurobiology

Volumn 26, Issue 3, 2006, Pages 225-235

  Kelicen, Pelin ^a   Nordberg, Agneta ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

A ; APP; Aromatase; Cholesterol; Human neuroblastoma cells (SHSY 5Y); SREBP

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; AROMATASE; CELL EXTRACT; CHOLESTEROL; ENZYME ANTIBODY; MEMBRANE PROTEIN; PROTEIN ANTIBODY; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME ANALYSIS; EXPERIMENTATION; FEEDBACK SYSTEM; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INCUBATION TIME; MOLECULAR DYNAMICS; NEUROBLASTOMA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SUPPLEMENTATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AROMATASE; CELL LINE, TUMOR; CULTURE MEDIA; FEEDBACK, BIOCHEMICAL; FEEDBACK, PHYSIOLOGICAL; HUMANS; MOLECULAR WEIGHT; NEUROBLASTOMA; PEPTIDE FRAGMENTS; STEROL REGULATORY ELEMENT BINDING PROTEINS;

EID: 33745070003     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-006-9060-x     Document Type: Article

References (25)

1. Annaert, W., and de Strooper, W. (1999). Presenilins: Molecular switches between proteolysis and signal transduction. Trends Neurosci. 22:439-443.
2. Azcoitia, I., Doncarlos, L. L., and Garcia-Segura, L. M. (2003a). Are gonadal steroid hormones involved in disorders of brain aging? Aging Cell 2:31-37.
3. Azcoitia, I., Sierra, A., Viega, S., and Garcia-Segura, L. M. (2003b). Aromatase expression by reactive astroglia is neuroprotective. Ann. N.Y. Acad. Sci. 107:298-305.
4. Brown, M. S., and Goldstein, J. L. (1997). The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340.
5. Brown, M. S., Rawson, J., Ye, R. B., and Goldstein, J. L. (2000). Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 100:391-398.
6. Browne, L. J., Gude, C., Rodriguez, H., Steele, R. E., and Bhatnagar, A. (1991). Fadrolole hydrochloride: A potent, selective, non-steroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J. Med. Chem. 34:725-736.
7. Cupers, P., Orlans, I., Craessaert, K., Annaert, W., and De Strooper, B. (2001). The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J. Neurochem. 78:1168-1178.
8. De Strooper, B., and Annaert, W. (2000). Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell Sci. 113:1857-1870.
9. Dooley, K. A., Millinder, S., and Osborne, T. F. (1998). Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme a synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y. J. Biol. Chem. 273:1349-1356.
10. Ericsson, J., Jackson, S. M., Kim, J. B., Spiegelman, B. M., and Edwards, P. A. (1997). Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor-1-and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272:7298-7305.
11. Fan, Q. W., Wei, Y., Senda, T., Yanagisawa, K., and Michikawa, M. (2001). Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J. Neurochem. 76:391-400.
12. Garcia-Ovejeroa, D., Azcoitiab, I., DonCarlosc, L. L., Melcangid, R. C., and Garcia-Segura, L. M. (2005). Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones. Brain Res. Rev. 48:273-286.
13. Gong, J. S., Sawamura, N., Zou, K., Sakai, J., Yanagisawa, K., and Michikawa, M. (2002). Amyloid beta-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade. J. Neurosci. Res. 70:438-446.
14. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992). Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359:322-325.
15. Hutchison, J. B., Wozniak, A., Beyer, C., and Hutcison, R. E. (1996). Regulation of sex-specific formation of oestrogen in brain development: Endogenous inhibitors of aromatase. J. Steroid. Biochem. Mol. Biol. 56:201-207.
16. Koudinov, A. R., and Koudinova, N. V. (2003). Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry 36:S107-S112.
17. Koudinov, A. R., Berezov, T. T., and Koudinova, N. V. (2002). Cholesterol and Alzheimer's disease: Is there a link? Neurology 58:1135.
18. Livonen, S., Corder, E., Lehtovirta, M., Helisalmi, S., Mannermaa, A., Vepsalainen, S., Hanninen, T., Soininen, H., and Hiltunen, M. (2004). Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease. Neurology 62:1170-1117.
19. Michikawa, M., Gong, J. S., Fan, Q. W., Sawamura, N., and Yangisawa, K. (2001). A novel action of amyloid β-protein (Aβ): Oligomeric Aβ promotes lipid efflux. J. Neurosci. 21:7226-7235.
20. Negri-Cesi, P., Poletti, A., and Celotti, F. (1996). Metabolism of steroids in the brain: A new insight into the role of 5α-reductase and aromatase in brain differentiations and functions. J. Steroid Biochem. Mol. Biol. 58:455-466.
21. Nguyen, L. B., Salen, G., Shefer, S., Tint, G. S., and Ruiz, F. (2001). Macrophage 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in sitosterolemia: Effects of increased cellular cholesterol and sitosterol concentrations. Metabolism 50:1224-1229.
22. Sanghera, M. K., Simpson, E. R., McPhaul, M. J., Kozlowski, G., Conley, A. J., and Lephart, E. D. (1991). Immunochemical distribution of aromatase cytochrome p450 in the rat brain using peptide-generated polyclonal antibodies. Endocrinology 129:2834-2844.
23. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. (1992). Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359:325-327.
24. Wozniak, A., Hutchison, R. E., Morris, C. M., and Hutchiason, J. B. (1998). Neuroblastoma and Alzheimer's disease brain cells contain aromatase activity. Steroids 63:263-267.
25. Zhang, J., Ye, W., Wang, R., Wolfe, M. S., Greenberg, B. D., and Selkoe, D. J. (2002). Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. J. Biol. Chem. 277:15069-15075.