Regulation of sex-specific formation of oestrogen in brain development: Endogenous inhibitors of aromatase

Journal of Steroid Biochemistry and Molecular Biology

Volumn 56, Issue 1-6, 1996, Pages 201-207

  Hutchison, J B ^a   Wozniak, A ^a   Beyer, C ^a,b   Hutchison, R E ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5BETA ANDROSTANOLONE; ANDROGEN; ANDROSTANEDIONE; AROMATASE; ESTROGEN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIRD; CHICKEN; CONFERENCE PAPER; ENZYME ACTIVITY; FETUS; GENE EXPRESSION REGULATION; HYPOTHALAMUS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; SEXUAL DEVELOPMENT;

EID: 0029963186     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-0760(95)00237-5     Document Type: Conference Paper

References (37)

1. MacLusky N. J. and Naftolin F.: Sexual differentiation of the central nervous system. Science 211 (1981) 1294-1303.
2. Arnold A. P. and Gorski R. A.: Gonadal steroid induction of structural sex differences in the central nervous system. A. Rev. Neurosci. 7 (1984) 413-422.
3. Pilgrim C. and Hutchison J. B.: Developmental regulation of sex differences in the brain: Can the role of gonadal steroids be redefined? Neuroscience 60 (1994) 843-855.
4. Garcia-Segura L. M., Baetens D. and Naftolin N.: Synaptic remodelling in arcurate nucleus after injection of estradiol valerate in adult female rats. Brain Res. 366 (1986) 131-136.
5. Naftolin F.: Brain aromatization of androgens. J. Reprod. Med. 39 (1994) 257-261.
6. Paul S. M. and Purdy R. H.: Neuroactive steroids. FASEB J. 6 (1992) 2311-2322.
7. Baulieu E.-E. and Robel P.: Neurosteroids: a new brain function? J. Steroid Biochem. Molec. Biol. 37 (1990) 395-403.
8. Lieberburg I., Wallach G. and McEwen B. S.: The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (CL-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain. Brain Res. 128 (1977) 176-181.
9. Simpson E. R., Mahendroo M. S., Means G. D., Kilgore M. W., Corbin C. J. and Mendelson C. R.: Tissue-specific promoters regulate aromatase cytochrome P450 expression. J. Steroid Biochem. Molec. Biol. 44 (1993) 321-330.
10. Hutchison J. B. and Steimer T.: Androgen metabolism in the brain: behavioural correlates. Prog. Brain Res. 61 (1984) 23-51.
11. Orchinik M., Murray T. F. and Moore F. L.: A corticosteroid receptor in neuronal membranes. Science 252 (1991) 1849-1850.
12. Ramirez V. D., Dluzen D. E. and Ke F. C.: Effects of progesterone and its metabolites on neuronal membranes. In Steroids and Neuronal Activity (Ciba Foundation Symposium 153). Wiley, Chichester (1990) pp. 125-144.
13. Means G. D., Mahendroo M. S., Corbin C. J., Mathis J. M., Powell F. E., Mendelson C. R. and Simpson E. R.: Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264 (1989) 19,385-19,391.
14. Hutchison J. B., Steimer Th. and Hutchison R. E.: Area-specific hormonal regulation of brain aromatase. Brain Res. 550 (1991) 95-100.
15. Roselli C. E., Salisbury R. L. and Resko J. A.: Genetic evidence for androgen-dependent and independent control of aromatase activity in the rat brain. Endocrinology 121 (1987) 2205-2210.
16. Hutchison J. B.: Aromatase: neuromodulator in the control of behavior. J. Steroid Biochem. Molec. Biol. 44 (1993) 509-520.
17. Balthazart J. and Foidart A.: Brain aromatase and the control of male sexual behavior. J. Steroid Biochem. Molec. Biol. 44 (1993) 521-540.
18. Beyer C., Wozniak A. and Hutchison J. B.: Sex-specific aromatization of testosterone in mouse hypothalamic neurons. Neuroendocrinology 58 (1993) 673-681.
19. Beyer C., Green S. and Hutchison J. B.: Androgens influence sexual differentiation of mouse hypothalamic neurons in vitro. Endocrinology 135 (1994) 1220-1226.
20. Reed M. J.: Commentary. Oestradiol 17-β hydroxysteroid dehydrogenase: its family and function. J. Endocr. 129 (1991) 163-165.
21. Reed M. J., Purohit A., Duncan L. J., Singh A., Roberts C. J., Williams G. J. and Potter B. V. L.: The role of cytokines and sulphatase inhibitors in regulating oestrogen synthesis in breast tumours. J. Steroid Biochem. Molec. Biol. 53 (1995) 413-420.
22. Steimer T. and Hutchison J. B.: Micromethods for the in vitro study of steroid metabolism in the brain using radiolabelled tracers. In Neuroendocrine Research Methods (Edited by B. Greenstein), Volume 2. Harwood Ac. Publishers, Switzerland (1991) Ch. 40, pp. 875-918.
23. Schlinger B. A., Fivizzani A. J. and Callard G. V.: Aromatase, 5α- and 5β-reductase in brain, pituitary and skin of the sex-role reversed Wilson's pharalope. J. Endocr. 122 (1989) 573-581.
24. Steimer T. and Hutchison J. B.: Metabolic control of the behavioural action of androgens in the dove brain: testosterone inactivation by 5β-reduction. Brain Res. 209 (1981) 189-204.
25. Hutchison J. B. and Steimer Th.: Brain 5β-reductase: a correlate of behavioural sensitivity to androgen. Science 213 (1981) 244-246.
26. Schlinger B. A., Amur-Umergee S., Campagnoni A. T. and Arnold A. P.: 5β-reductase and other androgen-metabolizing enzymes in primary cultures of developing zebra finch telecephalon. J. Neuroendocr. 7 (1995) 187-192.
27. Schumacher M., Hutchison R. E. and Hutchison J. B.: Inhibition of hypothalamic aromatase activity by 5-beta-dihydrotestosterone. J. Neuroendocr. 3 (1991) 221-226.
28. Demers L. M.: Effects of Fadrozole (CGS16949A) and Letrozole (CGS20267) on the inhibition of aromatase activity in breast-cancer patients. Breast Cancer Res. Treat. 30 (1994) 95-102.
29. Steele R. E., Mellor L. B., Sawyer W. K., Wasvary J. M. and Browne L. J.: In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS-16949A. Steroids 50 (1987) 147-162.
30. Wozniak A., Holman S.D. and Hutchison J. B.: In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS-16949A compared to steroidal inhibitors in brain tissue. J. Steroid Biochem. Molec. Biol. 43 (1992) 281-287.
31. Wozniak A. and Hutchison J. B.: Action of endogenous steroid inhibitors of brain aromatase relative to Fadrozole. J. Steroid Biochem. Molec. Biol. 44 (1993) 641-645.
32. Steimer Th. and Hutchison J. B.: In vivo study of brain steroid metabolism using intracerebral microdialysis: evidence for 5β-reduction of testosterone. J. Physiol. C 446 (1992) 279.
33. Amri H., Silberzahn P., Al-Timimi I. and Gaillard J.-L.: Aromatase activity in the mare ovary during estrous cycle. Measurement of endogenous steroids and of their in vitro inhibitory effect. Acta Endocr. 129 (1993) 536-542.
34. Plourde P. V., Dyroff M. and Dukes M.: Arimidex - a potent and selective 4th-generation aromatase inhibitor. Breast Cancer Res. Treat. 30 (1994) 103-111.
35. Browne L. J., Gude C., Rodriguez H., Steele R. E. and Bhatnagar A.: Fadrozole hydrochloride: a potent, selective, non-steroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J. Med. Chem. 34 (1991) 725-736.
36. Brodie A. M. H. and Wing L.-Y.: In vitro and in vivo studies with aromatase inhibitor 4-hydroxy-androstenedione. Steroids 50 (1987) 89-113.
37. Wozniak A., Holman S. D. and Hutchison J. B.: In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the brain. J. Steroid Biochem. Molec. Biol. 43 (1992) 281-287.