The role of water in computational and experimental derivation of binding thermodynamics in SH2 domains

Chemical Biology and Drug Design

Volumn 67, Issue 1, 2006, Pages 38-45

  Geroult, Sebastien ^a   Virdee, Satpal ^a   Waksman, Gabriel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Accessible surface area; Computational chemistry; Heat capacity change; Phosphotyrosine; Protein ligand interaction; SH2 domain; Structure; Thermodynamics

Indexed keywords

LIGAND; PHOSPHOPEPTIDE; PROTEIN SH2; WATER;

ARTICLE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; DERIVATIZATION; EMPIRICISM; ENERGY; HEAT; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SURFACE PROPERTY; THERMODYNAMICS;

COMPUTATIONAL BIOLOGY; LIGANDS; MODELS, MOLECULAR; ONCOGENE PROTEIN PP60(V-SRC); PHOSPHOPEPTIDES; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAINS; THERMODYNAMICS; WATER;

EID: 33745066058     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2005.00315.x     Document Type: Article

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