Rat genotype influences quantitative and qualitative aspects of xenogeneic immune response to pig blood mononuclear cells

Xenotransplantation

Volumn 13, Issue 4, 2006, Pages 299-307

  Bridle, Byram W ^a   Wilkie, Bruce N ^a   Jevnikar, Anthony M ^b,c   Mallard, Bonnie A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Genotype; Pig; Rat; Xenoreactive antibodies; Xenotransplantation

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2C; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; MITOGENIC AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DERMIS; GENOTYPE; GRAFT REJECTION; HOST; HYPOTHESIS; IMMUNOLOGICAL TOLERANCE; INBRED STRAIN; INJECTION; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; RECIPIENT; RISK ASSESSMENT; SWINE; XENOGRAFT;

ANIMALS; ANTIBODY FORMATION; HYPERSENSITIVITY, DELAYED; LEUKOCYTES, MONONUCLEAR; MALE; RATS; RATS, INBRED LEW; SPECIES SPECIFICITY; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 33745063145     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00306.x     Document Type: Article

References (33)

1. Cooper DK Gollackner B Sachs DH. Will the pig solve the transplantation backlog? Annu Rev Med 2002 53 : 133.
2. Cascalho M Platt JL. The immunological barrier to xenotransplantation. Immunity 2001 14 : 437.
3. Luppi P Rossiello MR Faas S Trucco M. Genetic background and environment contribute synergistically to the onset of autoimmune diseases. J Mol Med 1995 73 : 381.
4. Zielenski J. Genotype and phenotype in cystic fibrosis. Respiration 2000 67 : 117.
5. Hoffjan S Nicolae D Ostrovnaya I et al. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet 2005 76 : 696.
6. Zinkernagal RM Dunlop MB Doherty PC. Cytotoxic T cell activity is strain-specific in outbred mice infected with lymphocytic choriomeningitis virus. J Immunol 1975 115 : 1613.
7. Ovsyannikova IG Jacobson RM Poland GA. Variation in vaccine response in normal populations. Pharmacogenomics 2004 5 : 417.
8. Butcher GW Howard JC. Genetic control of transplantation rejection. Transplantation 1982 34 : 161.
9. Ilano AL McConnell MV Gurley KE et al. Cellular basis of allograft rejection in vivo. V. Examination of the mechanisms responsible for the differing efficacy of monoclonal antibody to CD4+ T cells in low- and high-responder rat strains. J Immunol 1989 143 : 2828.
10. Hall BM. Mechanisms of induction of tolerance to organ allografts. Crit Rev Immunol 2000 20 : 267.
11. Fritz FJ Pabst R Binns RM. Lymphocyte subsets and their proliferation in a model for a delayed-type hypersensitivity reaction in the skin. Immunology 1990 71 : 508.
12. Gracie JA Bradley JA. Interleukin-12 induces interferon-gamma-dependent switching of IgG antibody subclass. Eur J Immunol 1996 26 : 1217.
13. Saoudi A Bernard I Hoedemaekers A et al. Experimental autoimmune myasthenia gravis may occur in the context of a polarized Th1- or Th2-type immune response in rats. J Immunol 1999 162 : 7189.
14. Cêtre C Pierrot C Cocude C et al. Profiles of Th1 and Th2 cytokines after primary and secondary infection by Schistosoma mansoni in the semipermissive rat host. Infec Immun 1999 67 : 2713.
15. Bachmann MF Kopf M. The role of B cells in acute and chronic infections. Curr Opin Immunol 1999 11 : 332.
16. Huang J Garmise RJ Crowder TM et al. A novel dry powder influenza vaccine and intranasal delivery technology: induction of systemic and mucosal immune responses in rats. Vaccine 2004 23 : 794.
17. Yamada K Sachs DH DerSimonian H. Human anti-porcine xenogeneic T cell response: evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 1995 155 : 5249.
18. Wang H DeVries ME Deng S et al. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nature Med 2000 6 : 549.
19. Hsieh C-S Macatonia SE O'Garra A Murphy K. T cell genetic background determines default T helper phenotype development in vitro. J Exp Med 1995 181 : 713.
20. Gorczynski RM Fu X-M Chung S Sullivan B Chen Z. Manipulation of xenogeneic skin and/or renal graft survival in the rat-mouse concordant combination by portal vein pretransplant transfusion. Transpl Immunol 1995 3 : 321.
21. Bach FH Ferran C Hechenleitner P et al. Accommodation of vascularized xenografts: expression of ''protective genes'' by donor endothelial cells in a host Th2 cytokine environment. Nature Med 1997 3 : 196.
22. Zhu A. Binding of human natural antibodies to non-alpha Gal xeno-antigens on porcine erythrocytes. Transplant 2000 69 : 2422.
23. Miyatake T Sato K Takigami K et al. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection. J Immunol 1998 160 : 4114.
24. Gao ZH Zhong R Jiang J et al. Adoptively transferable tolerance induced by CD45RB monoclonal antibody. J Am Soc Nephrol 1999 10 : 374.
25. Gao Z McAlister VC Wright JR Jr. et al. Immunoglobulin-G subclass antidonor reactivity in transplant recipients. Liver Transpl 2004 10 : 1055.
26. Lindeborg E Kumagai-Braesch M Tibell A Christensson B Möller E. Biological activity of pig islet-cell reactive IgG antibodies in xenotransplanted diabetic patients. Xenotransplant 2004 11 : 457.
27. Clancy R Borody T Ren Z Pang G. Can the response to eradication therapy in Helicobacter pylori infection be predicted? Can J Gastroenterol Suppl 2003 17 ( suppl B 58B.
28. Tsuchiya T Ohshima K Karube K et al. Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL. Blood 2004 103 : 236.
29. Jordan WJ Brookes PA Szydlo RM et al. IL-13 production by donor T cells is prognostic of acute graft-vs.-host disease following unrelated donor stem cell transplantation. Blood 2004 103 : 717.
30. Guo H Qiao Z Zhu L et al. Th1/Th2 cytokine profiles and their relationship to clinical features in patients following nonmyeloablative allogeneic stem cell transplantation. Am J Hematol 2004 75 : 78.
31. Becker Y. The changes in the T helper 1 (Th1) and T helper 2 (Th2) cytokine balance during HIV-1 infection are indicative of an allergic response to viral proteins that may be reversed by Th2 cytokine inhibitors and immune response modifiers - a review and hypothesis. Virus Genes 2004 28 : 5.
32. Goleva E Dunlap A Leung DY. Differential control of TH1 vs. TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. J Allergy Clin Immunol 2004 114 : 183.
33. Ichim TE Wang H Zhong R. Multiple inherent response patterns to transplantation antigens. Curr Opin Organ Transplant 2005 10 : 15.