A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats

Food and Chemical Toxicology

Volumn 44, Issue 7, 2006, Pages 1158-1166

  Borzelleca, J F ^a   Peters, D ^b   Hall, W ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b 206 Carnegie Center   (United States)

^c Hall Consulting Inc ^*  (United States)

Author keywords

l theanine; Tea

Indexed keywords

AMINO ACID DERIVATIVE; THEANINE; UNCLASSIFIED DRUG;

ARTICLE; BEHAVIOR DISORDER; BLOOD CHEMISTRY; BODY WEIGHT DISORDER; CARCINOGENICITY; FOOD ANALYSIS; FOOD INTAKE; FOOD SAFETY; GENETIC PREDISPOSITION; HISTOPATHOLOGY; KIDNEY ADENOMA; MORBIDITY; MORTALITY; NONHUMAN; ORGAN WEIGHT; RAT; TOXICITY TESTING; TOXICOKINETICS; URINALYSIS;

ANIMALS; AREA UNDER CURVE; BEHAVIOR, ANIMAL; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; DIET; EATING; FEMALE; GLUTAMATES; HALF-LIFE; IMMUNE SYSTEM; KIDNEY; MALE; MOTOR ACTIVITY; ORGAN SIZE; RATS; SEX CHARACTERISTICS; URINALYSIS;

ANIMALIA;

EID: 33745055741     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.03.014     Document Type: Article

References (33)

1. Bukowski J.F., Morita C.T., and Brenner M.B. Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11 (1999) 57-65
2. Clark K.J., Grant P.G., Sarr A.B., Belakere J.R., Swaggerty C.L., Phillips T.D., and Woode G.N. An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. Vet. Microbiol. 63 (1998) 147-157
3. Desai M.J., Gill M.S., Hsu W.H., and Armstrong D.W. Pharmacokinetics of theanine enantiomers in rats. Chirality 17 (2005) 154-162
4. Egashira N., Hayakawa K., Mishima K., Kimura H., Iwasaki K., and Fujiwara M. Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice. Neurosci. Lett. 363 (2004) 58-61
5. Ferrara L., Montesano D., and Senatore A. The distribution of minerals and flavonoids in the tea plant (Camellia sinensis). Farmaco 56 (2001) 397-401
6. Graham H.N. Green tea composition, consumption, and polyphenol chemistry. Prev. Med. 21 (1992) 334-350
7. Gupta S., Saha B., and Giri A.K. Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. Mutat. Res. 512 (2002) 37-65
8. Kakuda T., Nozawa A., Unno T., Okamura N., and Okai O. Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat. Biosci. Biotechnol. Biochem. 64 (2000) 287-293
9. Kakuda T., Yanase H., Utsunomiya K., Nozawa A., Unno T., and Kataoka K. Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils. Neurosci. Lett. 289 (2000) 189-192
10. Kakuda T., Nozawa A., Sugimoto A., and Niino H. Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci. Biotechnol. Biochem. 66 (2002) 2683-2686
11. Kamath A.B., Wang L., Das H., Li L., Reinhold V.N., and Bukowski J.F. Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc. Natl. Acad. Sci. USA 100 (2003) 6009-6014
12. Kitaoka S., Hayashi H., Yokogoshi H., and Suzuki Y. Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine. Biosci. Biotechnol. Biochem. 60 (1996) 1768-1771
13. Komori A., Yatsunami J., Okabe S., Abe S., Hara K., Suganuma M., Kim S.J., and Fujiki H. Anticarcinogenic activity of green tea polyphenols. Jpn. J. Clin. Oncol. 23 (1993) 186-190
14. Miura Y., Chiba T., Tomita I., Koizumi H., Miura S., Umegaki K., Hara Y., Ikeda M., and Tomita T. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J. Nutr. 131 (2001) 27-32
15. Nagasawa K., Aoki H., Yasuda E., Nagai K., Shimohama S., and Fujimoto S. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem. Biophys. Res. Commun. 320 (2004) 116-122
16. Pillai S.P., Mitscher L.A., Menon S.R., Pillai C.A., and Shankel D.M. Antimutagenic/antioxidant activity of green tea components and related compounds. J. Environ. Pathol. Toxicol. Oncol. 18 (1999) 147-158
17. Rao A., Hu H., and Nobre A.C. The effects of combined caffeine and glucose drinks on attention in the human brain. Nutr. Neurosci. 8 (2005) 141-153
18. Sadzuka Y., Sugiyama T., Miyagishima A., Nozawa Y., and Hirota S. The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin. Cancer Lett. 105 (1996) 203-209
19. Sadzuka Y., Sugiyama T., and Hirota S. Modulation of cancer chemotherapy by green tea. Clin. Cancer Res. 4 (1998) 153-156
20. Song C.H., Jung J.H., Oh J.S., and Kim K.S. Effects of theanine on the release of brain alpha wave in adult males. Korean J. Nutrition 36 (2003) 919-923
21. Sugiyama T., and Sadzuka Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Cancer Lett. 133 (1998) 19-26
22. Sugiyama T., and Sadzuka Y. Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin. Cancer Res. 5 (1999) 413-416
23. Sugiyama T., Sadzuka Y., Tanaka K., and Sonobe T. Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicol. Lett. 121 (2001) 89-96
24. Terashima T., Takido J., and Yokogoshi H. Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine. Biosci. Biotechnol. Biochem. 63 (1999) 615-618
25. Unno T., Suzuki Y., Kakuda T., Hayakawa T., and Tsuge H. Metabolism of theanine, gamma-glutamylethylamide, in rats. J. Agric. Food Chem. 47 (1999) 1593-1596
26. Vijaya K., Ananthan S., and Nalini R. Antibacterial effect of theaflavin, polyphenon 60 (Camellia sinensis) and Euphorbia hirta on Shigella spp. - a cell culture study. J. Ethnopharmacol. 49 (1995) 115-118
27. Yokogoshi H., and Kobayashi M. Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats. Life Sci. 62 (1998) 1065-1068
28. Yokogoshi H., Kato Y., Sagesaka Y.M., Takihara-Matsuura T., Kakuda T., and Takeuchi N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 59 (1995) 615-618
29. Yokogoshi H., Kobayashi M., Mochizuki M., and Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem. Res. 23 (1998) 667-673
30. Yokogoshi H., Mochizuki M., and Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci. Biotechnol. Biochem. 62 (1998) 816-817
31. Yoshino K., Hara Y., Sano M., and Tomita I. Antioxidative effects of black tea theaflavins and thearubigin on lipid peroxidation of rat liver homogenates induced by tert-butyl hydroperoxide. Biol. Pharm. Bull. 17 (1994) 146-149
32. Zhang G., Miura Y., and Yagasaki K. Effects of dietary powdered green tea and theanine on tumor growth and endogenous hyperlipidemia in hepatoma-bearing rats. Biosci. Biotechnol. Biochem. 66 (2002) 711-716
33. Zheng G., Sayama K., Okubo T., Juneja L.R., and Oguni I. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 18 (2004) 55-62