Apyrase and 5′-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-β

Neurochemical Research

Volumn 31, Issue 4, 2006, Pages 455-462

  Spanevello, R M ^a   Mazzanti, C M ^a   Kaizer, R ^a   Zanin, R ^a   Cargnelutti, D ^a   Hannel, L ^a   Correa M ^a   Mazzanti, A ^b   Festugatto, R ^b   Graca D ^b   Schetinger, M R C ^a   Morsch, V M ^a  

^a Laboratorio de Sintese   (Brazil)

^b Centro de Ciencias Rurais   (Brazil)

Author keywords

5 Nucleotidase; Apyrase; Ethidium bromide; IFN ; Rat; Synaptosome

Indexed keywords

5' NUCLEOTIDASE; ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; APYRASE; BETA INTERFERON; ETHIDIUM BROMIDE; BIOLOGICAL RESPONSE MODIFIER; ENZYME INHIBITOR; ETHIDIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DEMYELINATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HYDROLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SYNAPTOSOME; ANIMAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DEMYELINATING DISEASE; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MYELIN SHEATH; PATHOLOGY; RANDOMIZATION; WISTAR RAT;

ANIMALIA;

5'-NUCLEOTIDASE; ADENINE NUCLEOTIDES; ANIMALS; APYRASE; BIOLOGICAL RESPONSE MODIFIERS; CEREBRAL CORTEX; DEMYELINATING DISEASES; ENZYME INHIBITORS; ETHIDIUM; INTERFERON-BETA; MALE; MYELIN SHEATH; RANDOM ALLOCATION; RATS; RATS, WISTAR; SYNAPTOSOMES;

EID: 33745046847     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9039-5     Document Type: Article

References (42)

1. Zimmermann H, Braun N, Kegel B, Heine P (1998) New insights into molecular structure and function of ectonucleotidases in the nervous system. Neurochem Int 32: 421-425
2. Bonan CD, Schetinger MRC, Battastini AMO, Sarkis JJF (2001) Ectonucleotidases and synaptic plasticity: implications in physiological and pathological conditions. Drug Dev Res 52: 57-65
3. Zimmermann H (1999) Two novel families of ectonucleotidases: molecular structures, catalytic properties and a search for function. TiPS 20: 231-236
4. Ziganshin AU, Hoyle C, Burnstock G (1994) Ecto-enzymes and metabolism of extracellular. ATP Drug Dev Res 32: 134-146
5. Zimmermann H (2001) Ectonucleotidases: some recent developments and a note on nomenclature. Drug Dev Res 52: 44-56
6. Battastini AMO, Rocha JBT, Barcellos CK, Dias R, Sarkis JJF (1991) Characterization of an ATP diphosphohydrolase (EC 3.6.1.5) in synaptosomes from cerebral cortex of adult rats. Neurochem Res 16:1303-1310
7. Zimmermann H (1996) Biochemistry, localization and functional roles of ectonucleotidases in the nervous system. Prog Neurobiol 49: 589-618
8. Ting-Fang W, Guidotti G (1998) Widespread expression of ectoapyrase (CD39) in the central nervous system. Brain Res 790: 318-322
9. Schetinger MRC, Falquembach F, Michelot F (1998) Heparin modulates adenine nucleotides hydrolysis by synaptosomes from cortex cerebral. Neurochem Int 33: 243-249
10. Schetinger MRC, Porto NM, Moretto MB, Morsch VM, Rocha JBT, Vieira V, Stefanello F (2000) New benzodiazepines alter acetylcholinesterase and ATPDase activities. Neurochem Res 25: 949-955
11. Balz D, Wyse A, Morsch VM, Silva AC, Vieira V, Morsch A, Schetinger MRC (2003) In vitro effects of L-arginine and guanidino compounds on NTPDase 1 and 5′-nucleotidase activities from rat brain synaptosomes. Int J Devl Neurosci 21: 75-82
12. Nedeljkovic N, Banjac A, Horvat A, Stojiljkovic M, Nikezic G (2005) Developmental profile of NTPDase activity in synaptic plasma membranes isolated from rat cortex cerebral. Int J Dev Neurosci 23: 45-51
13. Gibb A, Halliday FC (1996) Fast purinergic transmission in the central nervous system. Neuroscience 8: 225-232
14. Cunha RA, Ribeiro JA (2000) ATP as presynaptic modulator. Life Sci 68: 119-137
15. Fields RD, Stevens B (2000) ATP: an extracellular signaling molecule between neurons and glia. TINS 23: 625-633
16. Rathbone M, Middlemiss P, Gysbers J, Andrew C, Hermann M, Reed J, Ciccarelli R, Di Iorio P, Caciagli F (1999) Trophic effects of purines in neurons and glial cells. Prog Neurobiol 59: 663-690
17. Cunha RA (2001) Adenosine as a neuromodulator and as homeostatic regulator in the nervous system: different role, different sources and different receptors. Neurochem Int 38: 107-125
18. Dumwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24: 31-35
19. Stevens B, Porta S, Haak L, Gallo V, Fields D (2002) Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36: 855-868
20. Agresti C, Meomartini ME, Amadio S, Ambrosini E, Volonté C, Aloisi F, Visentin S (2005) ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptors. Brain Res Rev 48:157-165
21. Stangel M, Hartung H (2002) Remyelinating strategies for the treatment of multiple sclerosis. Prog Neurobiol 68: 361-376
22. Sotgiu S, Pugliatti M, Fois ML, Arru G, Sanna A, Sotgiu MA, Rossati G (2004) Genes, environment and susceptibility to multiple sclerosis. Neurobiol Dis 17:131-143
23. Reynolds R, Bello IC, Meeson A, Piddlesden S (1996) Comparison of a chemically mediated and an immunologically mediated demyelinating lesion model. Methods 10: 440-452. A companion to methods in enzymology
24. Buddeberg B, Kerschensteiner M, Merkler CS, Schwab M (2004) Behavioral testing strategies in a localized animal model of multiple sclerosis. J Neuroimmunol 153: 158-170
25. Graça DL, Bondan EF, Pereira LA, Fernandes CG, Maiorka PC (2001) Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system. Arq Neuropsiquiatr 59(2-B): 358-361
26. Guazzo E (2005) A technique for producing demyelination on the rat optic nerves. J Clin Neurosci 12(1): 54-58
27. Bondan EF, Lallo MA, Sinhorini IL, Pereira LAV and Graça DL et al. 2000. The effect of cyclophosphamide on brainstem remyelination following local ethidium bromide injection in Wistar rats. J Submicrosc Cytol Pathol 32: 603-612
28. Neuhaus O, Archelos J, Hartung HP (2003) Immunomodulation in multiple sclerosis: from immunosupression to neuroprotection. Trends Pharmac Sci 24: 131-138
29. Floris S, Ruuls S, Wierinckx A, Van Der Pol S, Dopp E, Meide P, Dykstra C, Vries H (2002) Interferon-β directly influences monocyte infiltration into the central nervous system. J Neuroimmunol 127: 69-79
30. Kawanokuchi J, Mizuno T, Kato H, Mitsuma N, Suzumura A (2004) Effects of interferon-β on microglial functions as inflammatory and antigen presenting cells in the central nervous system. Neuropharmacology 46: 734-742
31. Okada K, Kuroda E, Yoshida Y, Yamashita U, Suzumura A, Tsuji S (2005) Effects of interferon-β on the cytokine production of astrocytes. J Neuroimmunol 159: 48-54
32. Barca O, Ferré S, Seosane M, Prieto J, Lema M, Señarís R, Arce V (2003) Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. J Neuroimmunol 139:155-159
33. Nagy A, Delgado Escueta AV (1984). Rapid preparation of synaptosomes from mammalian brain using non-toxic isosmotic gradient material (Percoll). J Neurochem 43: 1114-1123
34. Heymann D, Reddington M, Kreutzberg GW (1984) Subcellular localization of 5′nucleotidase in rat brain. J Neurochem 43: 971-978
35. Chan K, Delfert D, Junger KD (1986) A direct colorimetric assay for Ca2+-ATPase activity. Anal Biochem 157: 375-378
36. Bradford MM (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
37. Schetinger MRC, Barcellos CK, Barlem A, Zwestch A, Gubert A, Bertuol C, Arteni N, Dias RD, Sarkis JJF, Netto CA (1994) Activity of synaptosomal ATP diphosphohydrolase from hipoccampus of rats tolerant to forebrain ischemia. Braz J Med Biol Res 27: 1123-1128
38. Bonan CD, Walz R, Pereira GS, Worm PV, Battastini AMO, Cavalheiro EA, Izquierdo I, Sarkis JJF (2000) Changes in synaptosomal ectonucleotidase activities in two rat models of temporal epilepsy. Epilepsy Res 39: 229-238
39. Torres IL, Buffon A, Silveira PA, Duarte M, Bassani MG, Oliveira S, Battastini A, Sarkis JJF, Dalmaz C, Ferreira MB (2002) Effect of chronic and acute stress on ectonucleotidase activities in spinal cord. Physiol Behav 75: 1-5
40. Penderis J, Shields S, Franklin R (2003) Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system. Brain 126: 1382-1391
41. Feuvre R, Brough D, Rothwell N (2002) Extracellular ATP and P2X7 receptors in neurodegeneration. Eur J Pharmacol 447: 261-269
42. Zhao C, Fancy S, Kotter M, Li W, Franklin R (2005) Mechanisms of CNS remyelination-the key to therapeutic advances. J Neurol Sci 233: 87-91