A technique for producing demyelination of the rat optic nerves

Journal of Clinical Neuroscience

Volumn 12, Issue 1, 2005, Pages 54-58

  Guazzo, Eric P ^a,b  

^a JAMES COOK UNIVERSITY   (Australia)

^b 4810 Australia ^*  (Australia)

Author keywords

demyelination; ethidium bromide; optic pathway; rat model; remyelination

Indexed keywords

ETHIDIUM BROMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; FEMALE; HISTOLOGY; MALE; NONHUMAN; OPTIC CHIASM; OPTIC NERVE; POPULATION RESEARCH; PRIORITY JOURNAL; RAT; SUBARACHNOID SPACE;

EID: 11444249332     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2004.08.002     Document Type: Article

References (11)

1. H. Cheng, Y. Caro, and L. Olson Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function Science 273 1996 510 513
2. Guazzo EP. Myelin: myelination, demyelination and remyelination, 2:5-38 in-Growth factors and remyelination in the rat spinal cord. MD thesis, University of Queensland, 2001
3. B.A. Newston The mode of action of phenanthridine: the effect of ethidium bromide on cell division and nucleic acid synthesis J Gen Microbiol 17 1957 718 730
4. D.L. Graca, and W.F. Blakemore Delayed remyelination in the rat spinal cord following ethidium bromide injection Neuropath App Neurobiol 12 1986 593 605
5. Graca DL. Investigation into ethidium bromide induced demyelination in the central nervous system. PhD thesis, University of Cambridge, UK, 1986
6. W.F. Blakemore, A.J. Crang, and R.J. Evans The effect of chemical injury on oligodendrocytes C.C. Mimms M.C. Cuzneks W. Kelly Viruses and demyelinating diseases 1983 Academic Press London 167 190
7. W.F. Blakemore, and K. Suzuki Ethidium bromide induced demyelination in the spinal cord of the cat Neuropath App Neurobiol 8 1979 365 385
8. R. Reynolds, and G.P. Wilkin Cellular reaction to an acute demyelinating/remyelinating lesion of the rat brainstem - localisation of GD3 ganglioside immunoreactivity J Neurosci Res 36 1993 417 434
9. R.J.M. Franklin Reconstructing myelin-deficient environments in the CNS by glial cell transplantation Sem Neurosci 5 1993 443 451
10. E.P. Guazzo, R.J.M. Franklin, and W.B. Blakemore A method for the continuous infusion of putative repair enhancing substances into the subarachnoid space of the rat spinal cord J Clin Neurosci 2 1994 339 344
11. Guazzo EP. Results on validation of optic apparatus model, 6:104-117 in-Growth factors and remyelination in the rat spinal cord. MD thesis, University of Queensland, 2001