Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women

European Journal of Clinical Nutrition

Volumn 60, Issue 5, 2006, Pages 681-687

  Mastaglia, S R ^a,b,c   Mautalen, C A ^b   Parisi, M S ^a,b   Oliveri, B ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c NONE   (Argentina)

Author keywords

Menopause; Osteopenia; Osteoporosis; Vitamin D; Vitamin D insufficiency; Vitamin D requirement

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; COLECALCIFEROL; CREATININE; ERGOCALCIFEROL; PARATHYROID HORMONE; PHOSPHATE; 25-HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS LINKED PEPTIDE; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; DRUG DERIVATIVE; PEPTIDE; VITAMIN D;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE DENSITY; BONE MINERAL; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE URINE LEVEL; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HUMAN; HYPERCALCIURIA; LONGITUDINAL STUDY; OSTEOPENIA; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; POSTMENOPAUSE OSTEOPOROSIS; RANDOMIZED CONTROLLED TRIAL; SPRING; VITAMIN BLOOD LEVEL; WINTER; BLOOD; DRUG EFFECT; METABOLIC BONE DISEASE; METABOLISM; MIDDLE AGED; NUTRITIONAL REQUIREMENT; SAFETY; SEASON; URINE; VITAMIN D DEFICIENCY;

AGED; ALKALINE PHOSPHATASE; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; COLLAGEN TYPE I; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERGOCALCIFEROLS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; NUTRITIONAL REQUIREMENTS; OSTEOPOROSIS, POSTMENOPAUSAL; PARATHYROID HORMONE; PEPTIDES; PHOSPHATES; SAFETY; SEASONS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 33745007961     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602369     Document Type: Article

References (34)

1. 3 in humans. J Clin Endocrinol Metab 89, 5387-5391.
2. Arnaud CD, Tsao HS, Littlediket T (1971). Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest 50, 21-31.
3. Bischoff H, Stahëlin H, Dick W, Akos R, Knecht M, Salis C et al. (2003). Effects of vitamin D and calcium supplementation on falls: A randomized controlled trial. J Bone Miner Res 18, 343-351.
4. Bischoff H, Willett W, Wong B, Giovannucci E, Dietrich T, Dawson-Hughes B (2005). Fracture prevention with vitamin D supplementation. JAMA 293, 2257-2293.
5. Boff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowascki J (1999). Occult vitamin D deficiency in postmenopausal women with acute hip fracture. JAMA 281, 1505-1511.
6. 2 cholecalciferol deficiency. Am J Clin Nutr 45, 755-763.
7. Brazier M, Kamel S, Maamer M, Agbomson F, Elesper I, Garabedian M et al. (1995). Markers of bone remodeling in the elderly subject: Effect of vitamin D insufficiency and its correction. J Bone Miner Res 10, 1753-1761.
8. 3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327, 1637-1642.
9. Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ (1996). Healthy elderly French women living at home have secondary hyperparathyroidism and high turnover in winter. J Clin Endocrinol 81, 1129-1133.
10. Dawson-Hughes B, Harris S, Krall E, Dallal G (1997). Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337, 670-676.
11. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R (2005). Estimates of optimal vitamin D status. Osteoporos Int 16, 713-716.
12. Farley JR, Hall SL, Ilacas D, Orcutt C, Miller BE, Hill CS et al. (1994). Quantification of skeletal alkaline phosphatase in osteoporotic serum by wheat germ agglutinin precipitation, heat inactivation, and a two-site immunoradiomeric assay. Clin Chem 40, 1749-1756.
13. Gloth FM, Gunberg CM, Hollis BW, Haddad JG, Tobin JD (1995). Vitamin D deficiency in homebound elderly persons. JAMA 274, 1683-1686.
14. Haden ST, Fuleihan GEH, Angell JE, Cotran NM, LeBoff MS (1999). Calcidiol and PTH levels in women attending an osteoporosis program. Calcif Tissue Int 64, 275-279.
15. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ (2003a). Human Serum 25 hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77, 204-210.
16. Heaney RP, Dowell M, Hale C, Bendich A (2003b). Calcium absorption varies within the reference range for serum 25-hydroxivitamin D. J Am Coll Nutr 22, 142-146.
17. Koster JC, Hackeng WH, Mulder H (1996). Disminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women. Eur J Clin Pharmacol 51, 145-147.
18. Lips P, Graafimans WC, Ooms ME, Bezemer PD, Bouyrt LM (1996). The vitamin D supplementation and fracture incidence in elderly people: A randomized placebo-controlled trial. Ann Intern Med 24, 400-406.
19. Malabanan A, Veronikis IE, Holick MF (1998). Redefining vitamin D insufficiency. Lancet 351, 805-806.
20. Mc Kenna M (1992). Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93, 69-77.
21. Mc Kenna MJ, Freaney R (1998). Secondary hyperparathyroidism in the elderly: Means to defining hypovitaminosis D. Osteoporos Int 8 (Suppl 2), 3-6.
22. Meyer H, Smedshaug G, Kvaavik E, Falch J, Tverdal A, Pedersen J (2002). Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomized controlled trial. J Bone Miner Res 4, 709-715.
23. Oliveri B, Plantalech L, Bagur A, Wittich A, Rovai G, Pusiol E et al. (2004). High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina. Eur J Clin Nutr 58, 337-342.
24. Ooms ME, Lips P, Roos JC, Van der Vijgh WJF, Popp-Snijders C, Bezemer D et al. (1995). Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res 8, 1177-1184.
25. Pfeifer M, Begerow B, Minne H (2002). Vitamin D and muscle function. Osteoporos Int 13, 187-194.
26. 3 supplement use on serum 25OHD concentration in elderly women in summer and winter. Calcif Tissue Int 74, 150-156.
27. Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick F (2003). Fortification of orange juice with vitamin D: A novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr 77, 1478-1483.
28. 2. Am J Clin Nutr 68, 854-858.
29. Trivedi DP, Doll R, Tee Khaw K (2003). Effect of four monthly oral vitamin D (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: Randomized double blind controlled trial. BMJ 326, 469-474.
30. Vega E, Bagur A, Mautalen C (1993). Densidad Mineral Ósea en Mujeres Osteoporóticas y Normales de Buenos Aires. Medicina (Buenos Aires) 53, 211-216.
31. Vieth R, Chan PCR, MacFarlane GD (2001). Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr 73, 288-294.
32. 3 adequate intake versus 100 mcg (4000IU) per day on biochemical responses and the well-being of patients. Nutr J 3, 8-17.
33. World Medical Association Declaration of Helsinki (2000). Ethical principles for medical research involving human subjects. JAMA 284, 3043-3045.
34. Yamanaka M, Ishijima M, Tokita A, Kitahara K, Enomoto F, Sawa M et al. (2004). Importance of the understanding of the 25-hydroxyvitamin D status for the alendronate treatment of postmenopausal osteoporosis. J Bone Min Res 19 (Suppl 1), S463, M495.