Improved capabilities of noncell-based permeability assays

American Laboratory

Volumn 38, Issue 8, 2006, Pages 26-29

  Kazan, Greg ^a  

^a MILLIPORE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ASSAYS; AUTOMATION; COST ACCOUNTING; ROBUSTNESS (CONTROL SYSTEMS);

DRUG DISCOVERY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY (PAMPA; PERMEABILITY ASSAYS; TRANSCELLULAR MEMBRANE PERMEABILITY;

DRUG PRODUCTS;

EID: 33745006653     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Review

References (5)

1. Kansy, M.; Senner, F.; Gubernator, K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.;. Med. Chem. 1998, 41, 1007-10.
2. Wohnsland, F.; Faller, B. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J. Med. Chem. 2001, 44, 923-30.
3. Di, L.; Kerns, E. Profiling drug-like properties in discovery research. Curr. Opin. Chem. Biol. 2003, 7, 402-8.
4. Brennan, M.B. Drug discovery (filtering out failures early in the game). Chem. Eng. News 2000, 78, 63.
5. Kansy, M.; Avdeef, A.; Fischer, H. Advances in screening for membrane permeability: high resolution PAMPA for medicinal chemists. Drug Discov. Today 2004, 1, 349-55.