Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds

European Journal of Medicinal Chemistry

Volumn 41, Issue 6, 2006, Pages 745-755

  Gilleron, P ^a   Millet, R ^a   Houssin, R ^a   Wlodarczyk, N ^a   Farce, A ^b   Lemoine, A ^a   Goossens, J F ^a   Chavatte, P ^b   Pommery, N ^a   Henichart J P ^a  

^a Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^b UNIV LILLE   (France)

Author keywords

Farnesyltransferase; Inhibitors; Peptidomimetics; Solid phase synthesis

Indexed keywords

1 [[1 (4 CYANOBENZYL)1H IMIDAZOL 5 YL]METHYL] BETA HOMOPROLYLPHENYLALANYLAMIDE; 1 [[1 (4 CYANOBENZYL)1H IMIDAZOL 5 YL]METHYL]PIPERIDINE 4 CARBONYLPHENYLALANYLAMIDE; 3 [[1 (4 CYANOBENZYL)1H IMIDAZOL 5 YL]METHYL] BETA ALANYLPHENYLALANYLAMIDE TRIFLUOROACETATE; [N (3 QUINOLYLMETHYL)] BETA HOMOPHENYLALANYLPHENYLALANYLAMIDE; [N (3 THIENYLMETHYL)] BETA HOMOPHENYLALANYLPHENYLALANYLAMIDE; [N (4 CYANOBENZYL 5 IMIDAZOLYLMETHYL)] BETA HOMOPHENYLALANYLPHENYLALANYLAMIDE; [N [4 (1H IMIDAZOL 1 YL)BENZYL]] BETA HOMOPHENYLALANYLPHENYLALANYLAMIDE; ANTINEOPLASTIC AGENT; PEPTIDE LIBRARY; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ISOLATION; HUMAN; HUMAN CELL; IC 50; MALE; METHODOLOGY; MOUSE; NONHUMAN; PROTEIN INTERACTION; RAT; SOLID;

ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES;

EID: 33744999161     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.03.017     Document Type: Article

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