Long hydrocarbon chains serve as unique molecular features recognized by ventral glomeruli of the rat olfactory bulb

Journal of Comparative Neurology

Volumn 498, Issue 1, 2006, Pages 16-30

  Ho, Sabrina L ^a   Johnson, Brett A ^a   Leon, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alkanes; Chemotopic organization; Combinatorial coding; Deoxyglucose; Glomeruli; Habituation; Odor similarity

Indexed keywords

ALKANE; ANISALDEHYDE; CARBON 14; CARVONE; DECANE; DEOXYGLUCOSE; HEPTANE; HEXADECANE; HEXANE; HYDROCARBON; MENTHONE; OCTANE; TETRADECANE; TRIDECANE;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; COMBINATORIAL CHEMISTRY; CONCENTRATION RESPONSE; GLOMERULUS; HABITUATION; NONHUMAN; ODOR; OLFACTORY BULB; OLFACTORY DISCRIMINATION; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT;

ALKANES; ANIMALS; BRAIN MAPPING; CARBON RADIOISOTOPES; DEOXYGLUCOSE; ENERGY METABOLISM; GLUCOSE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NEURONS; OLFACTORY BULB; RATS; RATS, WISTAR; SMELL; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 33744991638     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.20973     Document Type: Article

References (67)

1. Araneda RC, Kini AD, Firestein S. 2000. The molecular receptive range of an odorant receptor. Nat Neurosci 3:1248-1255.
2. Astic L, Saucier D. 1986. Anatomical mapping of the neuroepithelial projection to the olfactory bulb in the rat. Brain Res Bull 16:445-454.
3. Belluscio L, Katz LC. 2001. Symmetry, stereotypy, and topography of odorant representations in mouse olfactory bulbs. J Neurosci 21:2113-2122.
4. Bozza TC, Kauer JS. 1998. Odorant response properties of convergent olfactory receptor neurons. J Neurosci 18:4560-4569.
5. Bozza T, Feinstein P, Zheng C, Mombaerts P. 2002. Odorant receptor expression defines functional units in the mouse olfactory system. J Neurosci 22:3033-3043.
6. Cleland TA, Morse A, Yue EL, Linster C. 2002. Behavioral models of odor similarity. Behav Neurosci 116:222-231.
7. Curran-Everett D. 2000. Multiple comparisons: philosophies and illustrations. Am J Physiol Regul Integr Comp Physiol 279:R1-R8.
8. Ezeh PI, Davis LM, Scott JW. 1995. Regional distribution of rat electroolfactogram. Neurophysiology 73:2207-2220.
9. Friedrich RW, Korsching SI. 1997. Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging. Neuron 18:737-752.
10. Friedrich RW, Korsching SI. 1998. Chemotopic, combinatorial, and non-combinatorial odorant representations in the olfactory bulb revealed using a voltage-sensitive axon tracer. J Neurosci 18:9977-9988.
11. Fuss SH, Korsching SI. 2001. Odorant feature detection: activity mapping of structure response relationships in the zebrafish olfactory bulb. J Neurosci 21:8396-8407.
12. Hahn I, Scherer PW, Mozell MM. 1994. A mass transport model of olfaction. J Theor Biol 167:115-128.
13. Hornung DE, Mozell MM. 1977. Factors influencing the differential sorption of odorant molecules across the olfactory mucosa. J Gen Physiol 69:343-361.
14. Igarashi KM, Mori K. 2005. Spatial representation of hydrocarbon odorants in the ventrolateral zones of the rat olfactory bulb. J Neurophysiol 93:1007-1019.
15. Imamura K, Mataga N, Mori K. 1992. Coding of odor molecules by mitral/tufted cells in rabbit olfactory bulb. I. Aliphatic compounds. J Neurophysiol 68:1986-2002.
16. Joerges J, Küttner A, Galizia G, Menzel R. 1997. Internal representations for odours and combinatorial coding of odour mixtures visualized by optical imaging. Nature 387:285-288.
17. Johnson BA, Léon M. 2000a. Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration. J Comp Neurol 422:496-509.
18. Johnson BA, Leon M. 2000b. Odorant molecular length: one aspect of the olfactory code. J Comp Neurol 426:330-338.
19. Johnson BA, Woo CC, Leon M. 1998. Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb. J Comp Neurol 393:457-471.
20. Johnson BA, Woo CC, Hingco EE, Pham KL, Leon M. 1999. Multidimensional chemotopic responses to n-aliphatic acid odorants in the rat olfactory bulb. J Comp Neurol 409:529-548.
21. Johnson BA, Ho SL, Xu Z, Yihan JS, Yip S, Hingco EE, Leon M. 2002. Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. J Comp Neurol 449:180-194.
22. Johnson BA, Farahbod H, Xu Z, Saber S, Leon M. 2004. Local and global chemotopic organization: general features of the glomerular representations of aliphatic odorants differing in carbon number. J Comp Neurol 480:234-249.
23. Johnson BA, Farahbod H, Saber S, Leon M. 2005a. Effects of functional group position on spatial representations of aliphatic odorants in the rat olfactory bulb. J Comp Neurol 483:192-204.
24. Johnson BA, Farahbod H, Leon M. 2005b. Interactions between odorant functional group and hydrocarbon structure influence activity in glomerular response modules in the rat olfactory bulb. J Comp Neurol 483:205-216.
25. Katoh K, Koshimoto H, Tani A, Mori K. 1993. Coding of odor molecules by mitral/tufted cells in rabbit olfactory bulb. II. Aromatic compounds. J Neurophysiol 70:2161-2175.
26. Kauer JS, Cinelli AR. 1993. Are there structural and functional modules in the vertebrate olfactory bulb? Microsc Res Techniq 24:157-167.
27. Kent PF, Mozell MM, Murphy SJ, Hornung DE. 1996. The interaction of imposed and inherent olfactory mucosal activity patterns and their composite representation in a mammalian species using voltage-sensitive dyes. J Neurosci 16:345-353.
28. Kent PF, Mozell MM, Youngentob SL, Yurco P. 2003. Mucosal activity patterns as a basis for olfactory discrimination: comparing behavior and optical recordings. Brain Res 981:1-11.
29. Keyhani K, Scherer PW, Mozell MM. 1997. A numerical model of nasal odorant transport for the analysis of human olfaction. J Theor Biol 186:279-301.
30. Kimoto H, Touhara K. 2005. Induction of c-fos expression in mouse vomeronasal neurons by sex-specific non-volatile pheromone(s). Chem Senses 30:i146-i147.
31. Laska M, Freyer D. 1997. Olfactory discrimination ability for aliphatic esters in squirrel monkeys and humans. Chem Senses 22:457-465.
32. Laska M, Galizia CG. 2001. Enantioselectivity of odor perception in honeybees (Apis mellifera carnica). Behav Neurosci 115:632-639.
33. Laska M, Hübener F. 2001. Olfactory discrimination ability for homologous series of aliphatic ketones and acetic esters. Behav Brain Res 119:193-201.
34. Laska M, Teubner P. 1999. Olfactory discrimination ability for homologous series of aliphatic alcohols and aldehydes. Chem Senses 24:263-270.
35. Laska M, Galizia CG, Giurfa M, Menzel R. 1999. Olfactory discrimination ability and odor structure-activity relationships in honeybees. Chem Senses 24:429-438.
36. Laska M, Ayabe-Kanamura S, Hubener F, Saito S. 2001. Olfactory discrimination ability for aliphatic odorants as a function of oxygen moiety. Chem Senses 25:189-197.
37. Leon M, Johnson BA. 2003. Olfactory coding in the mammalian olfactory bulb. Brain Res Rev 42:23-32.
38. Linster C, Hasselmo ME. 1999. Behavioral responses to aliphatic aldehydes can be predicted from known electrophysiological responses of mitral cells in the olfactory bulb. Physiol Behav 66:497-502.
39. Linster C, Johnson BA, Yue E, Morse A, Xu Z, Hingco EE, Choi Y, Choi M, Messiha A, Léon M. 2001a. Perceptual correlates of neural representations evoked by odorant enantiomers. J Neurosci 21:9837-9843.
40. Linster C, Garcia PA, Hasselmo ME, Baxter MG. 2001b. Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Behav Neurosci 115:826-833.
41. Malnic B, Hirono J, Sato T, Buck LB. 1999. Combinatorial receptor codes for odors. Cell 96:713-723.
42. Meister M, Bonhoeffer T. 2001. Tuning and topography in an odor map on the rat olfactory bulb. J Neurosci 21:1351-1360.
43. Mezler M, Fleischer J, Breer H. 2001. Characteristic features and ligand specificity of the two olfactory receptor classes from Xenopus laevis. Exp Biol 204:2987-2997.
44. Moulton DG. 1976. Spatial patterning of response to odors in the peripheral olfactory system. Physiol Rev 56:578-593.
45. Mozell MM. 1964. Evidence for sorption as a mechanism of the olfactory analysis of vapours. Nature 203:1181-1182.
46. Mozell MM. 1966. The spatiotemporal analysis of odorants at the level of the olfactory receptor sheet. J Gen Physiol 50:25-41.
47. Mozell MM. 1970. Evidence for a chromatographic model of olfaction. J Gen Physiol 56:46-63.
48. Mozell MM, Jagodowicz M. 1973. Chromatographic separation of odorants by the nose: retention times measured across in vivo olfactory mucosa. Science 181:1247-1249.
49. Mozell MM, Sheehe PR, Hornung DE, Kent PF, Youngentob SL, Murphy SJ. 1987. "Imposed" and "inherent" mucosal activity patterns. Their composite representation of olfactory stimuli. J Gen Physiol 90:625-650.
50. Polak EH. 1973. Multiple profile-multiple receptor site model for vertebrate olfaction. J Theor Biol 40:469-484.
51. Ressler KJ, Sullivan SL, Buck LB. 1994. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79:1245-1255.
52. Rubin BD, Katz LC. 1999. Optical imaging of odorant representations in the mammalian olfactory bulb. Neuron 23:499-511.
53. Sachse S, Rappert A, Galizia CG. 1999. The spatial representation of chemical structures in the antennal lobe of honeybees: steps towards the olfactory code. Eur J Neurosci 11:3970-3982.
54. Sanz G, Schlegel C, Pernollet JC, Briand L. 2005. Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism. Chem Senses 30:69-80.
55. Schaefer ML, Yamazaki K, Osada K, Restrepo D, Beauchamp GK. 2002. Olfactory fingerprints for major histocompatibility complex-determined body odors II: relationship among odor maps, genetics, odor composition, and behavior. J Neurosci 22:9513-9521.
56. Schoenfeld TA, Knott TK. 2002. NADPH diaphorase activity in olfactory receptor neurons and their axons conforms to a rhinotopically-distinct dorsal zone of the hamster nasal cavity and main olfactory bulb. J Chem Neuroanat 24:269-285.
57. Schoenfeld TA, Knott TK. 2004. Evidence for the disproportionate mapping of olfactory airspace onto the main olfactory bulb of the hamster. J Comp Neurol 476:186-201.
58. Schoenfeld TA, Clancy AN, Forbes WB, Macrides F. 1994. The spatial organization of the peripheral olfactory system of the hamster. Part I: Receptor neuron projections to the main olfactory bulb. Brain Res Bull 34:183-210.
59. Scott JW, Davis LM, Shannon D, Kaplan C. 1996. Relation of chemical structure to spatial distribution of sensory responses in rat olfactory epithelium. J Neurophysiol 75:2036-2049.
60. Scott JW, Brierley T, Schmidt FH. 2000. Chemical determinants of the rat electro-olfactogram. J Neurosci 20:4721-4731.
61. Scott-Johnson PE, Blakley D, Scott JW. 2000. Effects of air flow on rat electroolfactogram. Chem Senses 25:761-768.
62. Takahashi YK, Kurosaki M, Hirono S, Mori K. 2004. Topographic representation of odorant molecular features in the rat olfactory bulb. J Neurophysiol 92:2413-2427.
63. Uchida N, Takahashi YK, Tanifuji M, Mori K. 2000. Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nat Neurosci 3:1035-1043.
64. Vassar R, Chao SK, Sitcheran R, Nunez JM, Vosshall LB, Axel R. 1994. Topographic organization of sensory projections to the olfactory bulb. Cell 79:981-991.
65. Wilson DA. 2000. Comparison of odor receptive field plasticity in the rat olfactory bulb and anterior piriform cortex. J Neurophysiol 84:3036-3042.
66. Zhang X, Firestein S. 2002. The olfactory receptor gene superfamily of the mouse. Nat Neurosci 5:1241-1233.
67. Zhang X, Rogers M, Tian H, Zhang X, Zou DJ, Liu J, Ma M, Shepherd GM, Firestein SJ. 2004. High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc Natl Acad Sci USA 101:14168-14173.