Insulin resistance demonstrated by a specific quantitative method in a hyperlipemic laminitic pony

Journal of Equine Veterinary Science

Volumn 26, Issue 6, 2006, Pages 271-274

  Hess, Tanja M ^a,b,c   Treiber, Kimberley H ^a,b,c   Kronfeld, David S ^a,b,c   Furr, Martin O ^a,b,c  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b MARION DUPONT SCOTT EQUINE MEDICAL CENTER   (United States)

^c Middleburg Agricultural Research and Extension Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EQUUS CABALLUS;

EID: 33744985025     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2006.04.009     Document Type: Article

References (27)

1. Jeffcott L., and Field J. Current concepts of hyperlipaemia in horses and ponies. Vet Rec 116 (1985) 461-466
2. Jeffcott L., Field J., McLean J., and O'Dea K. Glucose tolerance and insulin sensitivity in ponies and Standardbred horses. Equine Vet J 18 (1986) 97-101
3. Kronfeld D., Treiber K., and Geor R. Comparison of nonspecific indications and quantitative methods for the assessment of insulin resistance in horses and ponies. J Am Vet Med Assoc 225 (2005) 712-719
4. Bergman R., Ider Y., Bowden C., and Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol 236 (1979) E667-E677
5. Boston R., Stefanovski D., Moate P., Sumner A., Watanabe R., and Bergman R. MINMOD Millenium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 5 (2003) 1003-1015
6. Hoffman R., Boston R., Stefanovski D., Kronfeld D., and Harris P. Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J Anim Sci 81 (2003) 2333-2342
7. Treiber K., Kronfeld D., Boston R., Staniar W., and Harris P. Insulin resistance and compensation in Thoroughbred weanlings adapted to high-glycemic meals. J Anim Sci 83 (2005) 2357-2364
8. Rijnen K., and van der Kolk J. Determination of reference range values indicative of glucose metabolism and insulin resistance by use of glucose clamp techniques in horses and ponies. Am J Vet Res 64 (2003) 1260-1264
9. Treiber K., Kronfeld D., Hess T., Boston R., and Harris P. Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses. Am J Vet Res 66 (2005) 2114-2121
10. Kahn S. The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrin Metab 86 (2001) 4047-4058
11. Tasker J., Whiteman C., and Martin B. Diabetes mellitus in the horse. J Am Vet Med Assoc 149 (1966) 393-399
12. Baker J., and Ritchie H. Diabetes mellitus in the horse: a case report and review of the literature. Equine Vet J 6 (1974) 7-11
13. Muylle E., van den Hende C., Deprez P., Nuytten J., and Oyaert W. Non-insulin dependent diabtetes mellitus in a horse. Equine Vet J 18 (1986) 145-146
14. Saltiel A., and Kahn C. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414 (2001) 799-806
15. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 45 (1996) 3-10
16. Johnson P. The equine metabolic syndrome: peripheral Cushing's syndrome. Vet Clin Equine 18 (2002) 272-293
17. th Ann Conv Amer Assoc Equine Pract (2003) 21-25
18. Treiber K., Kronfeld D., Hess T., Byrd B., Splan R., and Staniar W. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc 228 (2006) 1538-1545
19. Treiber KH, Kronfeld DS, Geor RJ. Insulin resistance in equids-likely roles in laminitis. J Nutr (in press).
20. Pratt S., Geor R., McCutcheon J., et al. Repeatability of two methods for the assessment of glucose metabolism and insulin sensitivity in horses (abstract). J Vet Int Med 17 (2003) 455
21. Storlien L., Higgins J., Thomas T., Brown M., Wang H., Huang X., et al. Diet composition and insulin action in animal models. Br J Nutr 83 Suppl 1 (2000) S85-S90
22. Neeley K., and Herthel D. Essential fatty acid supplementation as a preventative for carbohydrate overload-induced laminitis. Proc Am Assoc Equine Pract 43 (1997) 367-369
23. Rivellese A., and Lilli S. Quality of dietary fatty acids, insulin sensitivity, and type 2 diabetes. Biomed Pharmacother 57 (2003) 84-87
24. Williams C., Kronfeld D., Staniar W., and Harris P. Plasma glucose and insulin responses of Thoroughbred mares fed a meal high in starch and sugar or fat and fiber. J Anim Sci 79 (2001) 2196-2201
25. Kronfeld D., and Harris P. Equine grain-associated disorders (EGAD). Compend Contin Educ Vet Pract 25 (2003) 974-982
26. Kronfeld D., Rodiek A., and Stull C. Glycemic index, glycemic load, and glycemic dietetics. J Equine Vet Sci 24 (2004) 399-404
27. Kronfeld DS, Treiber KH, Hess TM, Splan RK, Byrd BM, Staniar WB, White NA. Metabolic syndrome in healthy ponies facilitates nutritional countermeasures against pasture laminitis. J Nutr (in press).