Functional characterisation of the regulatory subunit of cyclic AMP-dependent protein kinase A homologue of Giardia lamblia: Differential expression of the regulatory and catalytic subunits during encystation

International Journal for Parasitology

Volumn 36, Issue 7, 2006, Pages 791-799

  Gibson, Candace ^a   Schanen, Brian ^a   Chakrabarti, Debopam ^a   Chakrabarti, Ratna ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Encystation; Expression; Giardia; Kinase activity; Localisation; PKA; Regulatory subunit

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE A; UNCLASSIFIED DRUG;

CLONE; CYST; ENCYSTMENT; ENZYME ACTIVITY; PARASITE; PROTEIN; PROTOZOAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; FLAGELLUM; GIARDIA LAMBLIA; KINETOSOME; LIFE CYCLE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; TANDEM REPEAT; TROPHOZOITE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA, PROTOZOAN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE LIBRARY; GIARDIA LAMBLIA; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TROPHOZOITES;

GIARDIA; GIARDIA INTESTINALIS;

EID: 33744979278     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2005.11.008     Document Type: Article

References (33)

1. Abel E.S., Davids B.J., Robles L.D., Loflin C.E., Gillin F.D., and Chakrabarti R. Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia. J. Biol. Chem. 276 (2001) 10320-10329
2. Adam R.D. The biology of Giardia spp. Microbiol. Rev. 55 (1991) 706-732
3. Adam R.D. Biology of Giardia lamblia. Clin. Microbiol. Rev. 14 (2001) 447-475
4. Ali S.A., and Hill D.R. Giardia intestinalis. Curr. Opin. Infect. Dis. 16 (2003) 453-460
5. Barradeau S., Imaizumi-Scherrer T., Weiss M.C., and Faust D.M. Intracellular targeting of the type-I alpha regulatory subunit of cAMP-dependent protein kinase. Trends Cardiovasc. Med. 12 (2002) 235-241
6. Bernander R., Palm J.E., and Svard S.G. Genome ploidy in different stages of the Giardia lamblia life cycle. Cell. Microbiol. 3 (2001) 55-62
7. Cassano S., Di Lieto A., Cerillo R., and Avvedimento E.V. Membrane-bound cAMP-dependent protein kinase controls cAMP-induced differentiation in PC12 cells. J. Biol. Chem. 274 (1999) 32574-32579
8. Falquet L., Pagni M., Bucher P., Hulo N., Sigrist C.J., Hoffmann K., and Bairoch A. The PROSITE database, its status in 2002. Nucleic Acids Res. 301 (2002) 235-238
9. Gibson R.M., Ji-Buechler Y., and Taylor S.S. Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit. J. Biol. Chem. 272 26 (1997) 16343-16350
10. Griffioen G., Anghileri P., Imre E., Baroni M.D., and Ruis H. Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae. J. Biol. Chem. 275 (2000) 1449-1456
11. Herberg F.W., Taylor S.S., and Dostmann W.R. Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry 35 (1996) 2934-2942
12. Kane A.V., Ward H.D., Keusch G.T., and Pereira M.E. In vitro encystation of Giardia lamblia: large-scale production of in vitro cysts and strain and clone differences in encystation efficiency. J. Parasitol. 77 (1991) 974-981
13. Lanfredi-Rangel A., Attias M., Reiner D.S., Gillin F.D., and De Souza W.J. Fine structure of the biogenesis of Giardia lamblia encystation secretory vesicles. J. Struct. Biol. 143 (2003) 153-163
14. Leon D.A., Herberg F.W., Banky P., and Tylor S.S. A stable alpha-helical domain at the N-terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif. J. Biol. Chem. 272 (1997) 28431-28437
15. Lewis D.J., and Freedman A.R. Giardia lamblia as an intestinal pathogen. Dig. Dis. 10 (1992) 102-111
16. Lu X.Y., Gross R.E., Bagchi S., and Rubin C.S. Cloning, structure, and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. J. Biol. Chem. 265 (1990) 3293-3303
17. Lujan H.D., Mowatt M.R., Byrd L.G., and Nash T.E. Cholesterol starvation induces differentiation of the intestinal parasite Giardia lamblia. Proc. Natl Acad. Sci. USA 93 (1996) 7628-7633
18. Mann S.K., and Firtel R.A. cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development. Development 119 (1993) 135-146
19. Mann S.K., Richardson D.L., Lee S., Kimmel S.R., and Firtel R.A. Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium. Proc. Natl Acad. Sci. USA 91 (1994) 10561-10565
20. Marques Mdo V., Borges A.C., de Oliveira J.C., and Gomes S.L. Coordinate pretranslational control of cAMP-dependent protein kinase subunit expression during development in the water mold Blastocladiella emersonii. Dev. Biol. 149 (1992) 432-439
21. Marti M., Regos A., Li Y., Schraner E.M., Wild P., Muller N., Knopf L.G., and Hehl A.B. An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis. J. Biol. Chem. 278 (2003) 24837-24848
22. McCaffery J.M., and Gillin F.D. Giardia lamblia: ultrastructural basis of protein transport during growth and encystation. Exp. Parasitol. 79 (1994) 220-235
23. Pan X., and Heitman J. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol. Cell. Biol. 19 (1999) 4874-4887
24. Primpke G., Iassonidou V., Nellen W., and Wetterauer B. Role of cAMP-dependent protein kinase during growth and early development of Dictyostelium discoideum. Dev. Biol. 221 (2000) 101-111
25. Reiner D.S., McCaffery J.M., and Gillin F.D. Reversible interruption of Giardia lamblia cyst wall protein transport in a novel regulated secretory pathway. Cell. Microbiol. 3 (2001) 459-472
26. Shalaby T., Liniger M., and Seebeck T. The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei. Eur. J. Biochem. 268 (2001) 6197-6206
27. Su Y., Dostmann W.R., Herberg F.W., Durick K., Xuong N.H., Ten Eyck L., Taylor S.S., and Varughese K.I. Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science 269 (1995) 807-813
28. Su Y., Ryder J., and Ni B. Inhibition of Abeta production and APP maturation by a specific PKA inhibitor. Fed. Eur. Biochem. Soc. Lett. 546 (2003) 407-410
29. Syin C., Parzy D., Traincard F., Boccaccio I., Joshi M.B., Lin D.T., Yang X.M., Assemat K., Doerig C., and Langsley G. The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes. Eur. J. Biochem. 268 (2001) 4842-4849
30. Telgmann R., Maronde E., Tasken K., and Gellersen B.E. Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells. Endocrinology 138 (1997) 929-937
31. Vigil D., Blumenthal D.K., Heller W.T., Brown S., Canaves J.M., Taylor S.S., and Trewhella J.D.K. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase a regulatory subunit homodimers: role of the linker regions. J. Mol. Biol. 337 (2004) 1183-1194
32. Yu S., Mei F.C., Lee J.C., and Cheng X. Probing cAMP-dependent protein kinase holoenzyme complexes Ialpha and IIbeta by FT-IR and chemical protein footprinting. Biochemistry 43 (2004) 1908-1920
33. Zhao Q., Tao J., Zhu Q., Jia P.M., Dou A.X., Li X., Cheng F., Waxman S., Chen G.Q., Chen S.J., Lanotte M., Chen Z., and Tong J.H. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia 18 (2004) 285-292