Hypoxic treatment inhibits insulin-induced chondrogenesis of ATDC5 cells despite upregulation of DEC1

Connective Tissue Research

Volumn 47, Issue 3, 2006, Pages 119-123

  Chen, Li ^a   Fink, Trine ^a   Ebbesen, Peter ^a   Zachar, Vladimir ^a  

^a AALBORG UNIVERSITY   (Denmark)

Author keywords

Chondrocyte; Chondrogenic differentiation; DEC1; Hypoxia

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COMPLEMENTARY DNA; HYPOXIA INDUCIBLE FACTOR 1; INSULIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DEC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; CULTURE MEDIUM; DNA SYNTHESIS; EMBRYO; GENE EXPRESSION; HISTOCHEMISTRY; HYPOXIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSCRIPTION INITIATION;

AGGRECANS; ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARTILAGE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHONDROCYTES; CHONDROGENESIS; COLLAGEN TYPE II; COLLAGEN TYPE X; EXTRACELLULAR MATRIX PROTEINS; HOMEODOMAIN PROTEINS; INSULIN; LECTINS, C-TYPE; MICE; PROTEOCHONDROITIN SULFATES; UP-REGULATION;

EID: 33744967105     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200600609558     Document Type: Article

References (19)

1. de Crombrugghe, B. and Lefebvre, V. and Nakashima, K. (2001) Regulatory mechanisms in the pathways of cartilage and bone formation Curr. Opin. Cell Biol., 13, pp. 721-727. [CSA]
2. Erlebacher, A. and Filvaroff, E. and Gitelman, S. and Derynck, R. (1995) Toward a molecular understanding of skeletal development Cell, 80, pp. 371-378. [CSA] [CROSSREF]
3. Hall, B. and Miyake, T. (2000) All for one and one for all: condensations and the initiation of skeletal development Bioessays, 22, pp. 138-147. [CSA] [CROSSREF]
4. Kielty, C. and Kwan, A. and Holmes, D. and Schor, S. and Grant, M. (1985) Type X collagen, a product of hypertrophic chondrocytes Biochem. J., 227, pp. 545-554. [CSA]
5. Zhou, S. and Cui, Z. and Urban, J. (2004) Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: A modeling study Arth. Rheum., 50, pp. 3915-3924. [CSA] [CROSSREF]
6. Schipani, E. and Ryan, H. and Didrickson, S. and Kobayashi, T. and Knight, M. and Johnson, R. (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival Genes Dev., 15, pp. 2865-2876. [CSA]
7. Pfander, D. and Cramer, T. and Schipani, E. and Johnson, R. (2003) HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes J. Cell. Sci., 116, pp. 1819-1826. [CSA] [CROSSREF]
8. Atsumi, T. and Miwa, Y. and Kimata, K. and Ikawa, Y. (1990) A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells Cell Differ. Dev., 30, pp. 109-116. [CSA] [CROSSREF]
9. Shukunami, C. and Shigeno, C. and Atsumi, T. and Ishizeki, K. and Suzuki, F. and Hiraki, Y. (1996) Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: Differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor J. Cell Biol., 133, pp. 457-468. [CSA] [CROSSREF]
10. Akiyama, H. and Shigeno, C. and Iyama, K. and Ito, H. and Hiraki, Y. and Konishi, J. and Nakamura, T. (1999) Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: Upregulation of type X collagen and osteoprotegerin ligand mRNAs Biochem. Biophys. Res. Commun., 257, pp. 814-820. [CSA] [CROSSREF]
11. Shukunami, C. and Ishizeki, K. and Atsumi, T. and Ohta, Y. and Suzuki, F. and Hiraki, Y. (1997) Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro J. Bone Miner. Res., 12, pp. 1174-1188. [CSA] [CROSSREF]
12. Shen, M. and Kawamoto, T. and Yan, W. and Nakamasu, K. and Tamagami, M. and Koyano, Y. and Noshiro, M. and Kato, Y. (1997) Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes Biochem. Biophys. Res. Commun., 236, pp. 294-298. [CSA] [CROSSREF]
13. Shen, M. and Yoshida, E. and Yan, W. and Kawamoto, T. and Suardita, K. and Koyano, Y. and Fujimoto, K. and Noshiro, M. and Kato, Y. (2002) Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages J. Biol. Chem., 277, pp. 50112-50120. [CSA] [CROSSREF]
14. Miyazaki, K. and Kawamoto, T. and Tanimoto, K. and Nishiyama, M. and Honda, H. and Kato, Y. (2002) Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes J. Biol. Chem., 277, pp. 47014-47021. [CSA] [CROSSREF]
15. Maclean, H. and Kronenberg, H. (2004) Expression of Stra13 during mouse endochondral bone development Gene Expr. Patterns, 4, pp. 633-636. [CSA] [CROSSREF]
16. Malda, J. and Martens, D. and Tramper, J. and van Blitterswijk, C. and Riesle, J. (2003) Cartilage tissue engineering: Controversy in the effect of oxygen Crit. Rev. Biotechnol., 23, pp. 175-194. [CSA]
17. Yun, Z. and Maecker, H. and Johnson, R. and Giaccia, A. (2002) Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia Dev. Cell, 2, pp. 331-41. [CSA] [CROSSREF]
18. Robins, J. and Akeno, N. and Mukherjee, A. and Dalal, R. and Aronow, B. and Koopman, P. and Clemens, T. (2005) Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9 Bone, 37, pp. 313-322. [CSA] [CROSSREF]
19. Yim, S. and Choi, S. and Choi, Y. and Lee, N. and Chung, J. and Park, H. (2003) Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1alpha J. Biol. Chem., 278, pp. 38260-38268. [CSA] [CROSSREF]