Human behaviour and development under high-altitude conditions

Developmental Science

Volumn 9, Issue 4, 2006, Pages 400-410

  Virués Ortega, Javier ^a,e   Garrido, Eduardo ^b   Javierre, Casimiro ^c   Kloezeman, Karen C ^d  

^a UNIVERSITY OF GRANADA   (Spain)

^b HOSPITAL GENERAL DE CATALUNYA   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY OF HAWAII   (United States)

^e CARLOS III INSTITUTE OF HEALTH   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ALTITUDE; ANOXIA; ARTICLE; BEHAVIOR; BRAIN; CHILD DEVELOPMENT; HUMAN; INFANT; LANGUAGE DEVELOPMENT; MEMORY; PATHOLOGY; PRESCHOOL CHILD;

ALTITUDE; ANOXIA; BEHAVIOR; BRAIN; CHILD DEVELOPMENT; CHILD, PRESCHOOL; HUMANS; INFANT; LANGUAGE DEVELOPMENT; MEMORY; OXYGEN;

EID: 33744951369     PISSN: 1363755X     EISSN: 14677687     Source Type: Journal    
DOI: 10.1111/j.1467-7687.2006.00505.x     Document Type: Article

References (116)

1. Acosta, J. de (1590). Historia Natural y Moral de las Indias [Natural and moral history of America] (V. III, pp. 140-146). Seville: Juan de Leon.
2. al Tahan, A., Buchur, J., el Khwsky, F., Ogunniyi, A., al-Rajeh, S., Larbi, E., Daif, A., & Bamgboye, E. (1998). Risk factors of stroke at high and low altitude areas in Saudi Arabia. Archives of Medical Research, 29, 173-177.
3. Anooshiravani, M., Dumont, L., Mardirosoff, C., Soto-Debeuf, G., & Delavelle, J. (1999). Brain magnetic resonance imaging (MRI) and neuronal changes after single high altitude climb. Medicine & Science in Sports & Exercise, 31, 969-972.
4. Bahrke, M.S., & Shukitt-Hale, B. (1993). Effect of altitude on mood, behavior and cognitive functioning. Sports Medicine, 16, 97-125.
5. Basnyat, B., Sherpa, N., Basyal, G., & Adhirikari, P. (1998). Children in the mountains: advice given was too conservative. British Medical Journal, 317, 540.
6. Beall, C.M. (2000a). Tibetan and Andean patterns of adaptation to high-altitude hypoxia. Human Biology, 72, 201-228.
7. Beall, C.M. (2000b). Oxygen saturation increases during childhood and decreases during adulthood among high altitude native Tibetans residing at 3800-4200 m. High Altitude Medicine and Biology, 1, 25-32.
8. Beall, CM., Decker, M.J., Brittenham, G.M., Kushner, I., Gebremedhin, A., & Strohl, K.P. (2002). Ethiopian pattern of human adaptation to high-altitude hypoxia. Proceedings of the National Academy of Sciences of the United States of America, 99, 17215-17218.
9. Beall, CM., & Goldstein, M.C. (1987). Hemoglobin concentration of pastoral nomads permanently resident at 4850-5450 meters in Tibet. American Journal of Physical Anthropology, 73, 433-438.
10. Beall, CM., Song, K., Elston, R.C., & Goldstein, M.C. (2004). Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4000 m. Proceedings of the National Academy of Sciences of the United States of America, 101, 14300-14304.
11. Benedek K., Kéri, S., Grósz, A., Tótka, Z., Tóth E., & Benedek, G. (2002). Short-term hypobaric hypoxia enhances visual contrast sensitivity. NeuroReport, 13, 1063-1066.
12. Berry, D., McConnell, J.W., Phillips, B.A., Carswell, CM., Lamb, D.G., & Prine, B.C. (1989). Isocapnic hypoxemia and neurobehavioural functioning. Journal of Clinical and Experimental Neuropsychology, 11, 241-251.
13. Bolmont, B., Bouquet, C., & Thullier, F. (2001). Relationship of personality traits with performance in RT, psychomotor ability, and mental efficiency during a 31-day simulated climb of Mount Everest in a hypobaric chamber. Perceptual and Motor Skills, 92, 1022-1030.
14. Bolmont, B., Thullier, F., & Abraini, J.H. (2000). Relationship between mood states and performances in RT, psychomotor ability, and mental efficiency during 31-day gradual decompression in a hypobaric chamber from sea level to 8848 m equivalent altitude. Physiology and Behaviour, 71, 469-476.
15. Botella, J., Garrido, E., & Catalá, J. (1993). Transient motor aphasia at high altitude. Revista Clínica Española, 193, 296-298.
16. Bouquet, C., Gardette, B., Gortan, C., Therme, P., & Abraini, J.H. (2000). Color discrimination under chronic hypoxia conditions (simulated climb 'Everest-Comex 97'). Perceptual and Motor Skills, 90, 169-179.
17. Brugger, P., Regard, M., Landis, T., & Oelz, O. (1999). Hallucinatory experiences in extreme-altitude climbers. Neuropsychiatry, Neuropsychology and Behavioural Neurology, 12, 67-71.
18. Cavaletti, G., Moroni, R., Garavaglia, P., & Tredici, G. (1987). Brain damage after high-altitude climbs without oxygen. The Lancet, 10, 101.
19. Clark, C.F., Heaton, R.K., & Weins, A.N. (1983). Neurobehavioural functioning after prolonged high altitude exposure in mountaineering. Aviation, Space and Environmental Medicine, 54, 202-207.
20. Crews, W.D., Jefferson, A.L., Bolduc, T., Elliott, J.B., Ferro, N.M., Broshek, D.K., Barth, IT, & Robbins, M.K. (2001). Neurobehavioural dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease. Archives of Clinical Neuropsychology, 16, 643-652.
21. Cymerman, A., Lieberman, P., Hochstadt, J., Rock, P.B., Butterfield, G.E., & Moore, L.G. (2002). Speech motor control and acute mountain sickness. Aviation, Space and Environmental Medicine, 73, 766-772.
22. Davis, H.Q., Kamimori, G.H., Kulesh, D.A., Mehm, W.J., Anderson, L.H., Elsayed, A.M., Burge, J.R., & Balkin, T.J. (1995). Visual performance with the Aviator Night Vision Imaging System (ANVIS) at a simulated altitude of 4300 meters. Aviation, Space and Environmental Medicine, 66, 430-434.
23. Denison, D.M., Ledwith, F., & Poulton, E.C. (1966). Complex reaction times at simulated cabin altitudes at 5000 feet and 8000 feet. Aerospace Medicine, 37, 1010-1013.
24. Dunlap, K. (1918). Medical studies in aviation: IV. Psychologic observations and methods. Journal of the American Medical Association, 71, 1392-1393.
25. Durmowicz., A.G., Noordeweir, E., Nicholas, R., & Reeves, J.T. (1997). Inflammatory processes may predispose children to high altitude pulmonary edema. Journal of Pediatrics, 130, 838-840.
26. Fowler, B., & Prlic, H. (1995). A comparison of visual and auditory reaction time and P300 latency thresholds to acute hypoxia. Aviation, Space and Environmental Medicine, 66, 645-650.
27. Freyre, E.A., & Ortiz, M.V. (1988). The effect of altitude on adolescent growth and development. Journal of Adolescent Health Care, 9, 144-149.
28. Gamponia, M.J., Babaali, H., Yugar, F., & Gilman, R.H. (1998). Reference values for pulse oximetry at high altitude. Archives of Disease in Childhood, 78, 461-465.
29. Garrido, E., Castelló, A., Ventura, J.L., Capdevila, A., & Rodriguez, FA. (1993). Cortical atrophy and other brain magnetic resonance imaging (MRI) changes after extremely high altitude climbs without oxygen. International Journal of Sport Medicine, 14, 232-234.
30. Garrido, E., Javierre, C., Ventura, J.L., & Segura, R. (2000). Hallucinatory experiences at high altitude. Neuropsychiatry, Neuropsychology and Behavioural Neurology, 13, 148.
31. Garrido, E., Segura, R., Capdevila, A., Aldomá, J., Rodriguez., F.A., Javierre, C., & Ventura, IL. (1995). New evidence from magnetic resonance imaging of brain changes after climbs at extreme altitude. European Journal of Applied Physiology, 70, 477-481.
32. Garrido, E., Segura, R., Capdevila, A., Pujol, J., Javierre, C., & Ventura, J.L. (1996). Are Himalayan Sherpas better protected against brain damage associated with extreme altitude climbs? Clinical Science, 90, 81-85.
33. Gonzáles, G.F. (1998). Patrones demográficos, reproductivos y de morbi-mortalidad en las poblaciones de altura del Perú [Demographic, reproductive, morbidity and mortality patterns in high altitude populations in Peru]. Acta Andina, 7, 85-93. Retrieved 1 June 2005 from http://sisbib.unmsm.edu.pe/BVRevistas/Acta_Andina/vol7_n2_1998/patrones.htm
34. Greene, L.S. (1973). Physical growth and development, neurological maturation and behavioural functioning in two Ecuadorian Andean communities in which goiter is endemic. American Journal of Physical Anthropology, 38, 119-134.
35. Haas, ID. (1976). Prenatal and infant growth and development. In P.T. Baker & M.A. Little (Eds.), Man in the Andes. A multidisciplinary study of high-altitude Quechua (pp. 161-179). Stroudsburg, PA: Dowden, Hutchinson & Ross.
36. Haas, J.D., Baker, P.T., & Hunt, E.E. (1977). The effects of high altitude on body size and composition of the infant in Southern Peru. Human Biology, 49, 611-628.
37. Hachinski, V.C., Potter, P., & Merskey, H. (1987). Leukoaraiosis. Archives of Neurology, 44, 21-23.
38. Hackett, PH. (1999). The cerebral etiology of high-altitude cerebral edema and acute mountain sickness. Wilderness and Environmental Medicine, 10, 97-109.
39. Hackett, P.H., & Roach, R.C. (2001). High-altitude illness. The New England Journal of Medicine, 345, 107-114.
40. Harris, N.S., Crawford, PB., Yangzom, Y., Pinzo, L., Gyaltsen, P., & Hudes, M. (2001). Nutritional and health status of Tibetan children living at high altitudes. New England Journal of Medicine, 344, 341-347.
41. Hayashi, R., Matsuzawa, Y., Kubo, K., & Kobayashi, T. (2005). Effects of simulated high altitude on event-related potential (P300) and auditory brain-stem responses. Clinical Neurophysiology, 116, 1471-1476.
42. Herzog, M. (1952). Annapurna, Premier 8000 [Annapurna, first 8000]. Paris: Arthaud.
43. Hochachka, P.W., Clark, CM., Brown, W.D., Stanley, C., Stone, C.K., Nickles, R.J., Zhu, G.G., Allen, P.S., & Holden, J.E. (1994). The brain at high altitude: hipometabolism as a defense against chronic hypoxia? Journal of Cerebral Blood Flow and Metabolism, 14, 671-679.
44. Hochachka, P.W., Clark, CM., Monge, C., Stanley, C., Brown, W.D., Stone, C.K., Nickles, R.J., & Holden, J.E. (1996). Sherpa brain glucose metabolism as defence adaptation against chronic hypoxia. Journal of Applied Physiology, 81, 1355-1361.
45. Hopkins, R.O., Kesner, R.P., & Goldstein, M. (1995). Item and order recognition memory in subjects with hypoxic brain injury. Brain and Cognition, 27, 180-201.
46. Hornbein, T.F. (1992). Long term effects of high altitude on brain function. International Journal of Sports and Medicine, 13, S43-S45.
47. Hornbein, T.F. (2001). The high altitude brain. The Journal of Experimental Biology, 204, 3129-3132.
48. Hornbein, T.F., Townes, B.D., Shoene, R.B., Sutton, J.R., & Houston C.S. (1989). The cost to the central nervous system of climbing to high extremely altitude. The New England Journal of Medicine, 321, 1714-1719.
49. Houston, C.S., Sutton, J.R., Cymerman, A., & Reeves, J.T. (1987). Operation Everest II: man at extreme altitude. Journal of Applied Physiology, 63, 877-882.
50. Jaillard, A.S., Hommel, M., & Mazetti, P. (1995). Prevalence of stroke at high altitude (3380 m) in Cuzco, a town of Peru: a population-based study. Stroke, 26, 562-568.
51. Janssen, J. (1890). Club Alpin Francais. Annuaire 1882-1887.
52. Jeong, J.H., Kwon, J.C., Chin, J., Yoon, S.J., & Na, D.L. (2002). Globus pallidus lesions associated with high mountain climbing. Journal of Korean Medical Science, 17, 861-863.
53. Kennedy, R.S., Dunlap, W.P., Banderet, L.E., Smith, M.G., & Houston, C.S. (1989). Cognitive performance deficits in a simulated ascent climb of Mount Everest: Operation Everest II. Aviation, Space and Environmental Medicine, 60, 99-104.
54. Keyes, L.E., Armaza, F., Niermeyer, S., Vargas, E., Young, D.A., & Moore, L.G. (2003). Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia. Pediatric Research, 54, 20-25.
55. Kida, M. (1997). Psychophysiological studies under simulated high altitude. Japanese Journal of Psychonomic Science, 16, 37-44.
56. Kobrick, IL., & Appleton, B. (1971). Effects of extended hypoxia on visual performance and retinal vascular state. Journal of Applied Physiology, 31, 357-362.
57. Kohlendorfer, U., Kiechl, S., & Sperl, W. (1998). Living at high altitude and risk of sudden infant death syndrome. Archives of Diseases in Childhood, 79, 506-509.
58. Kramer, A.F., Coyne, IT., & Strayer, D.L. (1993). Cognitive function at high altitude. Human Factors, 35, 329-344.
59. Leid, J., & Campagne, J. (2001). Colour vision at very high altitude. Color Research and Application, 26 (Suppl), S281-S283.
60. Lieberman, P., Protopapas, A., & Kanki, B.G. (1995). Speech production and cognitive deficits on Mt. Everest. Aviation, Space and Environmental Medicine, 66, 857-864.
61. Lieberman, P., Protopapas, A., Reed, E., Youngs, W., & Kanki, B.G. (1994). Cognitive defects at altitude. Nature, 372, 325.
62. Litch, J.A., & Bishop, R.A. (1999). Transient global amnesia at high altitude. The New England Journal of Medicine, 318, 1444.
63. McAnally, K.T., Watson, D.B., Martin, R.L., & Singh, B. (2003). Effect of hypobaric hypoxia on auditory sensitivity. Aviation, Space and Environmental Medicine, 74, 1251-1255.
64. McFarland, R.A. (1932). The psychological effects of oxygen deprivation (anoxemia) on human behaviour. Archives of Psychology, 145, 1-135.
65. McFarland, R.A. (1937). Psychophysiological studies at high altitude in the Andes. Journal of Comparative Physiology, 23, 191-225.
66. McFarland, R.A. (1972). Psychophysiological implications of life at altitude and including the role of oxygen in the process of aging. In M.K. Yousef, S.M. Horvath, & R.W. Bullard (Eds.), Physiological adaptations: Desert and mountain (pp. 157-182). New York: Academic Press.
67. Mackintosh, J.H., Thomas, D.J., Olive, J.E., Chesner, I.M., & Knight, R.J.E. (1988). The effect of altitude on tests of reaction time and alertness. Aviation, Space and Environmental Medicine, 59, 246-248.
68. Mikati, M.A., Zeinieh, M.P., Kurdi, R.M., Harb, S.A., El Hokayem, J.A., Daderian, R.H., Shamseddine, A., Obeid, M., Bitar, F.F., & El Sabban, M. (2005). Long term effects of acute and of chronic hypoxia on behavior and hippocampal histology in the developing brain. Developmental Brain Research, 157, 98-102.
69. Monge, C.C., León-Velarde, F., & Arregui, A. (2001). Chronic mountain sickness in Andeans. In T.F. Hornbein & R.B. Schoene (Eds.), High altitude: An exploration of human adaptation (pp. 815-838). New York: Marcel Dekker.
70. Moore, L.G. (2000). Comparative human ventilatory adaptation to high altitude. Respiration Physiology, 121, 257-276.
71. Moore, L.G. (2001). Human genetic adaptation to high altitude. High Altitude Medicine and Biology, 2, 257-279.
72. Moore, L.G., Curran-Everett, L., Droma, T.S., Groves, B.M., McCullough, R.E., McCullough, R.G., Sun, S.F., Sutton, J.R., Zamudio, S., & Zhuang, J.G. (1992). Are Tibetans better adapted? International Journal of Sports Medicine, 13 (Suppl. 1), 86-88.
73. Moore, L.G., Shriver, M., Bemis, L., Hickler, B., Wilson, M., Brutsaert, T., Parra, E., & Vargas, E. (2004). Maternal adaptation to high altitude pregnancy: an experiment of nature - a review. Placenta, 25, S60-S71.
74. Nelson, T.O., Dunlowsky, J., White, D.M., Steinberg, J., Townes, B.D., & Anderson, D. (1990). Cognition and metacognition at extreme altitudes on Mount Everest. Journal of Experimental Psychology: General, 119, 367-374.
75. Niaz, A., & Nayyar, S. (2003). Cerebrovascular stroke at high altitude. Journal of the College of Physicians and Surgeons - Pakistan, 13, 446-448.
76. Niermeyer, S., Zamudio, S., & Moore, L.G. (2001). The people. In T.F. Hornbein & R.B. Schoene (Eds.), High altitude: An exploration of human adaptation (pp. 43-100). New York: Marcel Dekker.
77. Niermeyer, S., Yang, P., Shanmina, M., Drolkar, R., Zhuang, J., & Moore L.G. (1995). Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet. New England Journal of Medicine, 333, 1248-1252.
78. Pelamatti, G., Pascotto, M., & Semenza, C. (2003). Verbal free recall in high altitude: proper names vs. common names. Cortex, 39, 97-103.
79. Phillips, L.W., & Pace, N. (1966). Performance changes at moderately high altitude: short-term memory measured by free recall. Psychological Reports, 19, 655-665.
80. Pollard, A.J., Murdoch, D.R., & Bärtsch, P. (1998). Children in the mountains. British Medical Journal, 316, 874-875.
81. Raman, L., Tkac, I., Ennis, K., Georgieff, M.K., Gruetter, R., & Rao, R. (2005). In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus. Developmental Brain Research, 156, 202-209.
82. Ravenhill, T.H. (1913). Some experiences of mountain sickness in the Andes. Journal of Tropical Medicine and Hygiene, 16, 313-320.
83. Regard, M., Oelz, O., Brugger, P., & Landis, T. (1989). Persistent cognitive impairment in climbers after repeated exposure to extreme altitude. Neurology, 39, 210-213.
84. Reite, M., Jackson, D., Cahoon, R.L., & Weil, J.W. (1975). Sleep physiology at high altitude. Electroencephalography and Clinical Neurophysiology, 38, 463-471.
85. Richalet, J.P., Souberbielle, J.C., Antezana, A.M., Dechaux, M., Le Trong, J.L., Bienvenu, A., Daniel, F., Blanchot, C., & Zittoun, J. (1994). Control of erythropoiesis in humans during prolonged exposure to the altitude of 6542 m. American Journal of Physiology, 266, 756-764.
86. Ruttledge, H. (1934). Everest: The unfinished adventure, 1933. London: Hodder and Stoughton.
87. Saco-Pollitt, C. (1981). Birth in the Peruvian Andes: physical and behavioural consequences in the neonate. Child Development, 52, 839-846.
88. Saco-Pollitt, C. (1989). Ecocultural context and developmental risk: birth in the high altitudes (Peru). In K.J. Nugent, B.M. Lester & T. Brazelton (Eds.), The cultural context of infancy: Biology, culture, and infant development (pp. 3-25). Westport, CT: Ablex Publishing.
89. Samuels, M.P. (2004). The effects of flight and altitude. Archives of Diseases in Childhood, 89, 448-455.
90. Schoene, R.B. (1999). The brain at high altitude. Wilderness and Environmental Medicine, 10, 93-96.
91. Sharma, V, Malhotra, M.S., & Baskaran, A. (1975). Variations in psychomotor efficiency during prolonged stay at high altitude. Ergonomics, 18, 511-516.
92. Sherriff, A., Emond, A., Bell, J.C., & Golding, J. (2001). Should infants be screened for anaemia? A prospective study investigating the relation between haemoglobin at 8, 12, and 18 months and development at 18 months. Archives of Disease in Childhood, 84, 480-485.
93. Shipton, E. (1943). Upon that mountain. London: Hodder and Stoughton.
94. Shukitt-Hale, B., Kadar, T., Marlowe, B.E., Stillman, M.J., Galli, R.L., Levy, A., Devine, J.A., & Lieberman, H.R. (1996). Morphological alterations in hippocampus following hypobaric hypoxia. Human and Experimental Toxicology, 15, 312-319.
95. Singh, S.B., Thakur, L., Anand, J.P., Yadav, D., Amitabh, Banerjee P.K., & Selvamurthy, W. (2004). Effect of high altitude on human auditory brainstem responses. Indian Journal of Physiology and Pharmacology, 48, 230-234.
96. Smith, V.C., Ernest, J.T, & Pokorny, J. (1976). Effect of hypoxia on FM 100-hue test performance. Modern Problems in Ophthalmology, 17, 248-256.
97. Soltani, M., & Knight, R.T. (2000). Neural origins of the P300. Critical Reviews in Neurobiology, 14, 199-224.
98. Sui, G.J., Liu, Y.H., Cheng, X.S., Anand, I.S., Harris, E., Harris, P., & Heath, D. (1988). Subacute infantile mountain sickness. Journal of Pathology, 155, 161-170.
99. Takagi, M., & Watanabe, S. (1999). Two different components of contingent negative variation (CNV) and their relation to changes in reaction time under hypobaric hypoxic conditions. Aviation, Space and Environmental Medicine, 70, 30-34.
100. Thilo, E.H., Park-Moore, B., Herman, E.R., & Carson, B.S. (1991). Oxygen saturation in healthy infants at an altitude of 1610m (5280 ft). What is normal? American Journal of Diseases in Childhood, 145, 1137-1140.
101. Townes, B., Hornbein, T., Schoene, R., Sarnquist, F., & Grant, I. (1984). Human cerebral function at extreme altitude. In J.B. West & S. Lahiri (Eds.), High altitude and man (pp. 31-36). Bethesda, DC: American Physiological Society.
102. Tronick, E.Z., Thomas, R.B., & Daltabuit, M. (1994). The Quechua manta pouch: a caretaking practice for buffering the Peruvian infant against the multiple Stressors of high altitude. Child Development, 65, 1005-1013.
103. Usui, C, Inoue, Y., Kimura, M., Kirino, E., Nagaoka, S., Abe, M., Nagata, T., & Arai, H. (2004). Irreversible subcortical dementia following high altitude illness. High Altitude Medicine and Biology, 5, 77-81.
104. Vázquez, J.C., Marentes, F., Aboitiz, C., Meza, S., & Pérez-Padilla, R. (2004). Clinical predictors of sleep disordered breathing in children at moderate altitude. Archives of Medical Research, 35, 525-531.
105. Villena M., Spielvogel, H., Vargas, E., Obert, P., Alarcon, A.M., Gonzales, C., Falgairette, G., & Kemper, H.C. (1994). Anthropometry and lung function of 10- to 12-year-old Bolivian boys. International Journal of Sports Medicine, 15 (Suppl. 2), 75-78.
106. Vingrys, A.J., & Garner, L.F. (1987). The effect of a moderate level of hypoxia on human color vision. Documenta Ophthalmologica, 66, 171-185.
107. Virués-Ortega, J., Buela-Casal, G., Garrido, E., & Alcázar B. (2004). Neurobehavioural functioning associated with high-altitude exposure. Neuropsychology Review, 14, 197-224.
108. Ward, M.P., Milledge, J.S., & West, J.B (2000). Women, children and elderly people at altitude. In M.P. Ward, J.S. Milledge, & J.B. West (Eds.), High altitude medicine and physiology (pp. 329-335). London: Arnold.
109. Wesensten, N.J., Crowley, J.B., & Thomas, K.G. (1993). Effects of simulated high altitude exposure on long latency event-related brain potentials and performance. Aviation, Space and Environmental Medicine, 64, 30-36.
110. West, J.B. (1984). Human physiology at extreme high altitudes on Mount Everest. Science, 323, 784-788.
111. West, J.B. (1986). Do climbs to extreme altitude cause brain damage? The Lancet, 16, 387-388.
112. Wilmer, W.H., & Berens, C. (1918). Medical studies in aviation: V. The effect of altitude on ocular functions. Journal of the American Medical Association, 71, 1394-1398.
113. Wong, S.H., Turner, N., Birchall, D., Walls, T.J., English, P., & Schmid, M.L. (2004). Reversible abnormalities of DWI in high-altitude cerebral edema. Neurology, 62, 335-336.
114. Wu, T., Li, S., & Ward, M.P. (2005). Tibetans at extreme altitude. Wilderness and Environmental Medicine, 16, 47-54.
115. Yaron, M., Waldman, N, Niermeyer, S., Nicholas, R., & Honigman, B. (1998). The diagnosis of acute mountain sickness in preverbal children. Archives of Pediatrics and Adolescent Medicine, 152, 683-687.
116. Yaron, M., Nieremyer, S., Lindgren, K.N., Hohigman, B., Strain, J.D., & Cairns, C.B. (2003). Physiologic response to moderate altitude exposure among infants and young children. High Altitude Medicine and Biology, 4, 53-59.