Morphological alterations in the hippocampus following hypobaric hypoxia

Human & Experimental Toxicology

Volumn 15, Issue 4, 1996, Pages 312-319

  Shukitt Hale, B ^a   Kadar, T ^c   Marlowe, B E ^b   Stillman, M J ^b   Galli, R L ^a   Levy, A ^c   Devine, J A ^a   Lieberman, H R ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

^c ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

chronic altitude exposure; delayed neurotoxicity; hippo campus; hypobaric hypoxia; ischemia

Indexed keywords

ALTITUDE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; CELL DEATH; CELL DEGENERATION; CONTROLLED STUDY; DELAYED NEUROTOXICITY; FOOD INTAKE; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOBARISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIME; WEIGHT REDUCTION;

ALTITUDE SICKNESS; ANIMALS; BODY WEIGHT; FEEDING BEHAVIOR; HIPPOCAMPUS; MALE; MAZE LEARNING; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0030004814     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719601500407     Document Type: Article

References (30)

1. Brierley JB Cerebral hypoxia. In: Greenfields neuropathology Blackwood W & Corsellis JAN (eds.) London: Edward Arnold, 1976; 43-85.
2. Bahrke MS, Shukitt-Hale B. Effects of altitude on mood, behaviour, and cognitive functioning: A review. Sports Medicine 1993; 16: 97-125.
3. Cavaletti G., Tredici G. Effects of exposure to low oxygen pressure on the central nervous system. Sports Medicine 1992; 13: 1-7.
4. Cavaletti G., Tredici G. Long-lasting neuropsychological changes after a single high altitude climb. Acta Neurologica Scandinavica 1993; 87: 103-5.
5. Mitani A., Kadoya F., Kataoka K. Distribution of hypoxia-induced calcium accumulation in gerbil hippocampal slice. Neuroscience Letters 1990; 120: 42-5.
6. Gibson GE, Freeman GB, Mykytyn V. Selective damage in striatum and hippocampus with in vitro anoxia. Neurochemical Research 1988; 13: 329-35.
7. Jensen MS, Lambert Jdc, Johansen FF Electrophysiological recordings from rat hippocampus slices following in vivo brain ischemia. Brain Research 1991; 554: 166-75.
8. Katoh A. et al. Ischemia-induced irreversible deficit of memory function in gerbils. Brain Research 1992; 577: 57-63.
9. Isaacson RL, Fahey JM Some anatomical and behavioural consequences of acute sodium nitrite administration. Neuroscience Research Communications 1987; 1: 39-45.
10. Hagan JJ, Beaughard M. The effects of forebrain ischaemia on spatial learning. Behavioural Brain Research 1990; 41: 151-60.
11. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Research 1982; 239: 57-69.
12. Ando S. et al. Delayed memory dysfunction by transient hypoxia, and its prevention with forskolin. Brain Research 1987; 405: 371-4.
13. Shukitt-Hale B. et al. Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion. Behavioural and Neural Biology 1994; 62: 244-52.
14. Devine JA, Cymerman A. An environmentally-controlled extended-use small animal hypobaric chamber. Aviation, Space, and Environmental Medicine 1987; 58: 473-6.
15. Campbell JA Further evidence that mammals cannot acclimatize to 10 p.c. oxygen or 20,000 feet altitude. British Journal of Experimental Pathology 1935; 16: 39-48.
16. Ettinger RH, Staddon Jer. Decreased feeding associated with acute hypoxia in rats. Physiology and Behavior 1982; 29: 455-8.
17. Paxinos G., Watson C. The rat brain in stereotaxic coordinates (2nd edn.). New York: Academic Press, 1986.
18. Kadar T., Silbermann M., Brandeis R., Levy A. Age-related structural changes in the rat hippocampus: Correlation with working memory deficiency. Brain Research 1990; 512: 113-20.
19. Kadar T., Silbermann M., Steinhagen-Thiessen E., Levy A. Age-related changes in the cholinergic components within the central nervous system of CW1 female mice, I. Structural analysis. Mechanisms of Ageing and Development 1989; 47: 133-44.
20. Hara H., Onodera H., Kogure K., Akaike N. The regional difference of neuronal susceptibility in the dentate gyrus to hypoxia. Neuroscience Letters 1990; 115: 189-94.
21. Garrido E. et al. Cortical atrophy and other brain magnetic resonance imaging (MRI) changes after extremely high-altitude climbs without oxygen. International Journal of Sports Medicine 1993; 14: 232-4.
22. Levy A., Dachir S., Arbel I., Kadar T. Aging, stress and cognitive function. In: Pharmacology of Aging Processes, Annals of the New York Academy of Science, 717. Nagi I, Harman D & Kitani K (eds.). New York: The New York Academy of Science, 1994; 79-88.
23. Markowska AL, Breckler SJ, Olton DS Memory and sensorimotor skills in aged rats: effects of age, strain, gender and diet restriction. Society for Neuroscience Abstracts 1993; 19: 601.
24. Regard M., Oelz O., Brugger P., Landis T. Persistent cognitive impairment in climbers after repeated exposure to extreme altitude. Neurology 1989; 39: 210-3.
25. Wiard RP, Carroll MS, Beek O., Cooper BR Assessment of the effects of various durations of cerebral ischemia followed by reperfusion on performance in the Morris water maze in gerbils. Society for Neuroscience Abstracts 1992; 18: 1581.
26. Shukitt-Hale B. et al. Morphology and muscarinic receptor density in the rat brain following exposure to hypobaric hypoxia. Society for Neuroscience Abstracts 1991; 17: 1532.
27. Kerr DS et al. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. The Journal of Neuroscience 1991; 11: 1316-24.
28. Ou LC, Smith RP Probable strain differences of rats in susceptibilities and cardiopulmonary responses to chronic hypoxia. Respiration Physiology 1983; 53: 367-77.
29. Gibson GE, Pulsinelli W., Blass JP, Duffy TE Brain dysfunction in mild to moderate hypoxia. The American Journal of Medicine 1981; 70: 1247-54.
30. Katz IR Is there a hypoxic affective syndrome? Psychosomatics 1982; 23: 846-53.