α-ketoglutarate-supplemented enteral nutrition: Effects on postoperative nitrogen balance and muscle catabolism

Nutrition

Volumn 18, Issue 9, 2002, Pages 725-728

  Wirén, Mikael ^a   Permert, Johan ^a   Larsson, Jörgen ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ketoglutarate; Enteral nutrition; Muscle catabolism; Nitrogen balance; Surgery

Indexed keywords

2 OXOGLUTARIC ACID; 3 METHYLHISTIDINE; C PEPTIDE; NITROGEN; PREALBUMIN;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; ELECTIVE SURGERY; ENTERIC FEEDING; FEASIBILITY STUDY; FEMALE; HUMAN; MALE; NITROGEN BALANCE; NUTRITIONAL INTOLERANCE; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN METABOLISM; RANDOMIZED CONTROLLED TRIAL; URINALYSIS;

ABDOMEN; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ENTERAL NUTRITION; FEMALE; HUMANS; KETOGLUTARIC ACIDS; MALE; METHYLHISTIDINES; MIDDLE AGED; MUSCLE, SKELETAL; NITROGEN; PILOT PROJECTS; POSTOPERATIVE CARE; SERUM ALBUMIN; TREATMENT OUTCOME;

EID: 0036752888     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(02)00844-4     Document Type: Article

References (21)

1. Bristol J.B., Williamson R.C.N. Nutrition, operations and intestinal adaptation. JPEN. 12:1988;299.
2. Riecken E.O., Stallmach A., Zeitz M., et al. Growth and transformation of the small intestinal mucosa - importance of connective tissue, gut associated lymphatic tissue and gastrointestinal regulatory peptides. Gut. 30:1989;1630.
3. Moore F.A., Feliciano D.V., Andrassy R.J., et al. Early enteral feeding, compared with parenteral, reduces postoperative septic complications. Ann Surg. 216:1992;172.
4. Beire-Holgersen R., Boersby S. Influence of postoperative enteral nutrition on surgical infections. Gut. 39:1996;833.
5. Braga M., Vignali A., Gianotti L., et al. Immune and nutritional effects of early enteral nutrition after major abdominal operations. Eur J Surg. 162:1996;105.
6. Souba W.W., Herskowitz K., Austgen T.R., Chen M.K., Salloum R.M. Glutamine nutrition theoretical considerations and therapeutic impact . JPEN. 14:1990;237.
7. Houdijk A.P.J., Rijnsburger E.R., Jansen J., et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple traumas. Lancet. 352:1998;772.
8. Houdijk A.P.J., van Leeuwen P.A.M., Teerlink T., et al. Glutamine-enriched enteral diet increases renal arginine production. JPEN. 18:1994;422.
9. Hammarqvist F., Strömberg C., von der Decken A., Vinnars E., Wernermann J. Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery. Surgery. 109:1991;28.
10. Blomqvist B.I., Hammarqvist F., von der Decken A., Wernerman J. Glutamine, and α-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism. 44:1995;1215.
11. Winkler S., Hotzenbein T., Karner J., Roth E. Kinetics of organ specific metabolism of a bolus injection into the jejunum of glutamine, α-ketoglutarate ornithine and ornithine α-ketoglutarate. Clin Nutr. 12:1993;56.
12. Le Boucher J., Coudray-Lucas C., et al. Enteral administration of ornithine α-ketoglutarate or arginine α-ketoglutarate a comparative study of their effects in burn-injured rats . Crit Care Med. 25:1997;293.
13. Cerra F.B., Lehmann S., Konstantinides N., et al. Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA and menhaden oil is independent of nitrogen balance. Nutrition. 7:1991;193.
14. Daly J.M., Lieberman M.D., Goldfine J., et al. Enteral nutrition with supplemented arginine, RNA and omega-3-fatty acids in patients after operation immunologic, metabolic and clinical outcome . Surgery. 112:1992;56.
15. Van der Hulst R.R., von Kreel B.K., von Meyenfeldt M.F., et al. Glutamine and the preservation of gut integrity. Lancet. 341:1993;1363.
16. Jeevanandam M., Holaday N.J., Petersen S.R. Ornithine-[alpha-ketoglutarate] (OKG) supplementation is more effective than its component salts in traumatized rats. J Nutr. 126:1996;2141.
17. Le Bricon T., Coudray-Lucas C., Lioret N., et al. Ornithine [alpha-ketoglutarate] metabolism after enteral administration in burn patients bolus compared with continuous infusion . Am J Clin Nutr. 65:1997;512.
18. De Bandt J.P., Cynober L.A. Amino acids with anabolic properties. Curr Opin Clin Nutr Metab Care. 1:1998;263.
19. Cynober L.A. The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care. Curr Opin Clin Nutr Metab Care. 2:1999;33.
20. Yang H., Wirén M., Larsson J., Permert J. Whole-protein-based enterable formula stimulates intestinal ornithine decarboxylase activity more than single amino acids but does not affect mucosal adenosine triphosphate content in early postsurgical refeeding. JPEN. 23:1999;207.
21. Riedel E., Nundel M., Hampl H. α-Ketoglutarate application in hemodialysis patients improves amino acid metabolism. Nephron. 74:1996;261.