Absorption of α-ketoglutarate by the gastrointestinal tract of pigs

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 138, Issue 2, 2004, Pages 215-220

  Buddington, Randal K ^a   Pajor, Ana ^b   Buddington, Karyl K ^a   Pierzynowski, Stefan ^c  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c Ideon Science Park   (Sweden)

Author keywords

Absorption; Colon; Dicarboxylic acid; NaDC 1; Small intestine; Stomach; Transporter; Ketoglutarate

Indexed keywords

2 OXOGLUTARIC ACID; AMINO ACID; DICARBOXYLIC ACID; SUCCINIC ACID; TRICARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON; CORRELATION ANALYSIS; DIET; FEEDING; GASTROINTESTINAL TRACT; IMMUNOREACTIVITY; INTESTINE ABSORPTION; INTESTINE CELL; MEASUREMENT; METABOLISM; NONHUMAN; PORTAL VEIN BLOOD FLOW; SMALL INTESTINE; SODIUM TRANSPORT; STOMACH; SWINE; UPREGULATION; WEANING; WESTERN BLOTTING;

EID: 3242740432     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpb.2004.03.007     Document Type: Article

References (20)

1. Bai L., Pajor A.M. Expression cloning of NaDC-2, an intestinal Na(+) - or Li(+) - dependent dicarboxylate transporter. Am. J. Physiol. 273:1997;G267-G276
2. Browne J.L., Sanford P.A., Smyth D.M. Transfer and metabolism of citrate, succinate, alpha-ketoglutarate and pyruvate by hamster small intestine. Proc. R. Soc. Lond. B. Biol. Sci. 200:1978;117-135
3. Buddington R.K., Elnif J., Puchal-Gardiner A.A., Sangild P.T. Intestinal apical amino acid absorption during development of the pig. Am. J. Physiol. 280:2001;R241-247
4. Holowachuck S.A., Bal'a M.F., Gerard P.D., Buddington R.K. Nonparallel secretion of antibacterial activity and protein in porcine pancreatic juice. Pancreas. 28:2004;E32-E38
5. Howell J.A., Matthews A.D., Swanson K.C., Harmon D.L., Matthews J.C. Molecular identification of high-affinity glutamate transporters in sheep and cattle forestomach, intestine, liver, kidney, and pancreas. J. Anim. Sci. 79:2001;1329-1336
6. Karasov W.M., Diamond J.M. A simple method for measuring intestinal solute uptake in vitro. J. Comp. Physiol. B152:1983;105-116
7. Kristensen N.B., Jungvid H., Fernandez J.A., Pierzynowski S.G. Absorption and metabolism of -ketoglutarate in growing pigs. J. Anim. Physiol. Anim. Nutr. 86:2002;239-245
8. Junghans P., Derno M., Pierzynowski S., Hennig U., Souffrant W.-B. Utilization of α-ketoglutarate (AKG) in young growing pigs after intra-venous and intra-duodenal administration. Souffrant W.-B., Metges C.C. Progress in Research on Energy and Protein Metabolism. EAAP Publication. vol. 109:2003;521-523. Rostock-Warnemuende
9. Lambert B.D., Stoll B., Niinikoski H., Pierzynowski S., Burrin D.G. Net portal absorption of enterally fed α-ketoglutarate is limited in young pigs. J. Nutr. 132:2002;3383-3386
10. Pajor A.M. Sodium-coupled transporters for Krebs cycle intermediates. Annu. Rev. Physiol. 61:1999;663-682
11. Pajor A.M., Sun N.N. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am. J. Physiol. 279:2000;F482-490
12. +-dicarboxylate cotransporter NaDC-1. Biochem. J. 331:1998;257-264
13. Puchal A.A., Buddington R.K. Postnatal development of monosaccharide transport in pig intestine. Am. J. Physiol. 262:1992;G895-902
14. Reeds P.J., Burrin D.G. The gut and amino acid homeostasis. Nutrition. 16:2000;666-668
15. Ritzhaupt A., Wood I.S., Ellis A., Hosie K.B., Shirazi-Beechey S.P. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J. Physiol. 513:1998;719-732
16. Stoll B., Burrin D.G., Henry J., Yu M., Jahoor F., Reeds P.J. Dietary amino acids are the preferential source of hepatic protein synthesis in piglets. J. Nutr. 128:1998;1517-1524
17. + gradient. Am. J. Physiol. 284:2003;F763-769
18. Wolffram S., Hagemann C., Grenacher B., Scharrer E. Characterization of the transport of tri- and dicarboxylates by pig intestinal brush-border membrane vesicles. Comp. Biochem. Physiol., A. 101:1992;59-67
19. Wolffram S., Badertscher M., Scharrer E. Carrier-mediated transport is involved in mucosal succinate uptake by rat large intestine. Exp. Physiol. 79:1994;215-226
20. Wolffram S., Unternahrer R., Grenacher B., Scharrer E. Transport of citrate across the brush border and basolateral membrane of rat small intestine. Comp. Biochem. Physiol., A. 109:1994;39-52