Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 6, 2006, Pages

  Linscheid, Philippe ^a   Seboek, Dalma ^a   Zulewski, Henryk ^a   Scherberich, Arnaud ^a   Blau, Nenad ^b   Keller, Ulrich ^a   Mülle, Beat ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Adipose tissue; Cytokines; Insulin resistance; Lipolysis; Nitric oxide synthase

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TETRAHYDROBIOPTERIN;

ADIPOCYTE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; LIPOLYSIS; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; OMENTUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; SUBCUTANEOUS FAT;

ADIPOCYTES; ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; BIOPTERIN; CYTOKINES; DRUG SYNERGISM; GLYCEROL; HUMANS; INSULIN; MESENCHYMAL STEM CELLS; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PPAR GAMMA;

EID: 33744930569     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00374.2005     Document Type: Article

References (48)

1. Aaronson DS and Horvath CM. A road map for those who don't know JAK-STAT. Science 296: 1653-1655, 2002.
2. Adam L, Bouvier M, and Jones TL. Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling. J Biol Chem 274: 26337-26343, 1999.
3. Alderton WK, Cooper CE, and Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 357: 593-615, 2001.
4. Andersson K, Gaudiot N, Ribiere C, Elizalde M, Giudicelli Y, and Arner P. A nitric oxide-mediated mechanism regulates lipolysis in human adipose tissue in vivo. Br J Pharmacol 126: 1639-1645, 1999.
5. Arner P. Resistin: yet another adipokine tells us that men are not mice. Diabetologia 48: 2203-2205, 2005.
6. Bedard S, Marcotte B, and Marette A. Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase. Biochem J 325: 487-493, 1997.
7. Berg AH, Lin Y, Lisanti MP, and Scherer PE. Adipocyte differentiation induces dynamic changes in NF-κB expression and activity. Am J Physiol Endocrinol Metab 287: E1178-E1188, 2004.
8. Bogdan C. Nitric oxide and the immune response. Nat Immun 2: 907-916, 2001.
9. Curtius HC, Blau N, and Kuster FA. Pterines. Techniques in Diagnostic Human Biochemical Genetics, edited by Hommes T. New York, NY: Wiley-Liss, 1991, p. 377-396.
10. Dandona P, Aljada A, and Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25: 4-7, 2004.
11. Daveu C, Servy C, Dendane M, Marin P, and Ducrocq C. Oxidation and nitration of catecholamines by nitrogen oxides derived from nitric oxide. Nitric Oxide 1: 234-243, 1997.
12. Ding M, St. Pierre BA, Parkinson JF, Medberry P, Wong JL, Rogers NE, Ignarro LJ, and Merrill JE. Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis. J Biol Chem 272: 11327-11335, 1997.
13. Eizirik DL, and Mandrup-Poulsen T. A choice of death: the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44: 2115-2133, 2001.
14. Elizalde M, Ryden M, van Harmelen V, Eneroth P, Gyllenhammar H, Holm C, Ramel S, Olund A, Arner P, and Andersson K. Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans. J Lipid Res 41: 1244-1251, 2000.
15. Engeli S, Janke J, Gorzelniak K, Bohnke J, Ghose N, Lindschau C, Luft FC, and Sharma AM. Regulation of the nitric oxide system in human adipose tissue. J Lipid Res 45: 1640-1648, 2004.
16. Feingold KR, Doerrler W, Dinarello CA, Fiers W, and Grunfeld C. Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. Endocrinology 130: 10-16, 1992.
17. Floyd ZE and Stephens JM. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem 277: 4062-4068, 2002.
18. Fujiwara K, Mori K, Kaneko YS, Nakashima A, Nagasaka A, Itoh M, and Ota A. Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide. Biochim Biophys Acta 1670: 181-198, 2004.
19. Ganster RW, Taylor BS, Shao L, and Geller DA. Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci USA 98: 8638-8643, 2001.
20. Gaudiot N, Jaubert AM, Charbonnier E, Sabourault D, Lacasa D, Giudicelli Y, and Ribiere C. Modulation of white adipose tissue lipolysis by nitric oxide. J Biol Chem 273: 13475-13481, 1998.
21. Gaudiot N, Ribiere C, Jaubert AM, and Giudicelli Y. Endogenous nitric oxide is implicated in the regulation of lipolysis through antioxidant-related effect. Am J Physiol Cell Physiol 279: C1603-C1610, 2000.
22. Granger DL, Taintor RR, Boockvar KS, and Hibbs JB Jr. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol 268: 142-151, 1996.
23. Granneman JG, Li P, Lu Y, and Tilak J. Seeing the trees in the forest: selective electroporation of adipocytes within adipose tissue. Am J Physiol Endocrinol Metab 287: E574-E582, 2004.
24. Hauner H, Skurk T, and Wabitsch M. Cultures of human adipose precursor cells. Methods Mol Biol 155: 239-247, 2001.
25. Kapur S, Marcotte B, and Marette A. Mechanism of adipose tissue iNOS induction in endotoxemia. Am J Physiol Endocrinol Metab 276: E635-E641, 1999.
26. Klatt P, Cacho J, Crespo MD, Herrera E, and Ramos P. Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist. Biochem J 351: 485-493, 2000.
27. Kleinert H, Pautz A, Linker K, and Schwarz PM. Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500: 255-266, 2004.
28. Leitner KL, Meyer M, Leimbacher W, Peterbauer A, Hofer S, Heufler C, Muller A, Heller R, Werner ER, Thony B, and Werner-Felmayer G. Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase. Biochem J 373: 681-688, 2003.
29. Linscheid P, Keller U, Blau N, Schaer DJ, and Muller B. Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes. Biochem Pharmacol 65: 593-598, 2003.
30. Linscheid P, Seboek D, Nylen ES, Langer I, Schlatter M, Becker KL, Keller U, and Muller B. In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinology 144: 5578-5584, 2003.
31. Luss H, Li RK, Shapiro RA, Tzeng E, McGowan FX, Yoneyama T, Hatakeyama K, Geller DA, Mickle DA, Simmons RL, and Billiar TR. Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. J Mol Cell Cardiol 29: 1153-1165, 1997.
32. Marrogi A, Pass HI, Khan M, Metheny-Barlow LJ, Harris CC, and Gerwin BI. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. Cancer Res 60: 3696-3700, 2000.
33. Moncada S and Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012, 1993.
34. Penfornis P and Marette A. Inducible nitric oxide synthase modulates lipolysis in adipocytes. J Lipid Res 46: 135-142, 2005.
35. Perreault M and Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7: 1138-1143, 2001.
36. Pickup JC and Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41: 1241-1248, 1998.
37. Pilon G, Dallaire P, and Marette A. Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. J Biol Chem 279: 20767-20774, 2004.
38. Pilon G, Penfornis P, and Marette A. Nitric oxide production by adipocytes: a role in the pathogenesis of insulin resistance? Horm Metab Res 32: 480-484, 2000.
39. Ribiere C, Jaubert AM, Gaudiot N, Sabourault D, Marcus ML, Boucher JL, Denis-Henriot D, and Giudicelli Y. White adipose tissue nitric oxide synthase: a potential source for NO production. Biochem Biophys Res Commun 222: 706-712, 1996.
40. Rodriguez-Pascual F, Hausding M, Ihrig-Biedert I, Furneaux H, Levy AP, Forstermann U, and Kleinert H. Complex contribution of the 3′-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J Biol Chem 275: 26040-26049, 2000.
41. Roy D, Perreault M, and Marette A. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent. Am J Physiol Endocrinol Metab 274: E692-E699, 1998.
42. Ryden M, Dicker A, Gotherstrom C, Astrom G, Tammik C, Arner P, and Le Blanc K. Functional characterization of human mesenchymal stem cell-derived adipocytes. Biochem Biophys Res Commun 311: 391-397, 2003.
43. Ryden M, Elizalde M, van Harmelen V, Ohlund A, Hoffstedt J, Bringman S, and Andersson K. Increased expression of eNOS protein in omental versus subcutaneous adipose tissue in obese human subjects. Int J Obes Relat Metab Disord 25: 811-815, 2001.
44. Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, and Martyn JA. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Am J Physiol Endocrinol Metab 282: E386-E394, 2002.
45. Waite KJ, Floyd ZE, Arbour-Reily P, and Stephens JM. Interferon-gamma- induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J Biol Chem 276: 7062-7068, 2001.
46. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, and Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003.
47. Wellen KE and Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119, 2005.
48. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, and Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830, 2003.