Low density lipoprotein aged in plasma forms clusters resembling subendothelial droplets: Aggregation via surface sites

Biophysical Journal

Volumn 90, Issue 11, 2006, Pages 4239-4247

  De Spirito, Marco ^a   Brunelli, Roberto ^b   Mei, Giampiero ^c   Bertani, Francesca R ^d,f   Ciasca, Gabriele ^a   Greco, Giulia ^d   Papi, Massimiliano ^a   Arcovito, Giuseppe ^a   Ursini, Fulvio ^e   Parasassi, Tiziana ^d  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; FRACTAL ANALYSIS; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIPID OXIDATION; LIPOLYSIS; NORMAL HUMAN; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SUBENDOTHELIUM;

EID: 33744925898     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.075788     Document Type: Article

References (36)

1. Skålén, K., M. Gustafsson, E. Knutsen Rydberg, L. Mattsson Hultén, O. Wiklund, T. L. Innerarity, and J. Borén. 2002. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature. 417:750-754.
2. Öörni, K., M. O. Pentikäinen, M. Ala-Korpela, and P. T. Kovanen. 2000. Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions. J. Lipid Res. 41:1703-1714.
3. Piha, M., L. Lindstedt, and P. T. Kovanen. 1995. Fusion of proteolyzed low-density lipoprotein in the fluid phase: a novel mechanism generating atherogenic lipoprotein particles. Biochemistry. 34:10120-10129.
4. Nievelstein, P. F., A. M. Fogelman, G. Mottino, and J. S. Frank. 1991. Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue. Arterioscler. Thromb. 11:1795-1805.
5. Pentikäinen, M. O., E. M. P. Lehtonenm, K. Öörni, S. Lusa, P. Somerharju, M. Jauhiainen, and P. T. Kovanen. 1997. Human arterial proteoglycans increase the rate of proteolytic fusion of low density lipoprotein particles. J. Biol. Chem. 272:25283-25288.
6. Hakala, J. K., K. Öörni, M. O. Pentikäinen, E. Hurt-Camejo, and P. T. Kovanen. 2001. Lipolysis of LDL by human secretory phospholipase A(2) induces particle fusion and enhances the retention of LDL to human aortic proteoglycans. Arterioscler. Thromb. Vasc. Biol. 21:1053-1058.
7. Öörni, K., J. K. Hakala, A. Annila, M. Ala-Korpela, and P. T. Kovanen. 1998. Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles. J. Biol. Chem. 273:29127-29134.
8. McNamara, J. R., D. M. Small, Z. Li, and E. J. Schaefer. 1996. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B. J. Lipid Res. 37:1924-1935.
9. Galeano, N. F., R. Milne, Y. L. Marcel, M. T. Walsh, E. Levy, T. D. Ngu'yen, A. Gleeson, Y. Arad, L. Witte, M. Al-Haideri, S. C. Rumsey, and R. J. Deckelbaum. 1994. Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyceride-rich LDL of normal size. J. Biol. Chem. 269:511-519.
10. Tikkanen, M. J., T. G. Cole, K. S. Hahm, E. S. Krul, and G. Schonfeld. 1984. Expression of apolipoprotein B epitopes in very low density lipoprotein subfractions. Studies with monoclonal antibodies. Arteriosclerosis. 4:138-146.
11. Marcel, Y. L., M. Hogue, P. K. Weech, J. Davignon, and R. W. Milne. 1988. Expression of apolipoprotein B epitopes in lipoproteins. Relationship to conformation and function. Arteriosclerosis. 8:832-844.
12. Kinoshita, M., E. S. Krul, and G. Schonfeld. 1990. Modification of the core lipids of low density lipoproteins produces selective alterations in the expression of apoB-100 epitopes. J. Lipid Res. 31:701-708.
13. Chen, G. C., S. Zhu, D. A. Hardman, J. W. Schilling, K. Lau, and J. P. Kane. 1989. Structural domains of human apolipoprotein B-100. Differential accessibility to limited proteolysis of B-100 in low density and very low density lipoproteins. J. Biol. Chem. 264:14369-14375.
14. Chen, G. C., K. Lau, R. L. Hamilton, and J. P. Kane. 1991. Differences in local conformation in human apolipoprotein B-100 of plasma low density and very low density lipoproteins as identified by cathepsin D. J. Biol. Chem. 266:12581-12587.
15. Campos, H., K. S. Arnold, M. E. Balestra, T. L. Innerarity, and R. M. Krauss. 1996. Differences in receptor binding of LDL subfractions. Arterioscler. Thromb. Vasc. Biol. 16:794-801.
16. Weitz, D. A., M. Y. Lin, and J. S. Huang. 1987. Fractal and scaling in kinetic colloid aggregation. In Physics of Complex and Supermolecular Fluids. S. A. Safran and N. A. Dark, editors. Wiley-Interscience, New York. 509-545.
17. Mandelbrot, B. B. 1982. The Fractal Geometry of Nature. Freeman, San Francisco.
18. Weitz, D. A., and M. Oliveria. 1984. Fractal structures formed by kinetic aggregation of aqueous gold colloids. Phys. Rev. Lett. 52:1433-1436.
19. Lin, M. Y., H. M. Lindsay, D. A. Weitz, R. C. Ball, and R. Klein. 1989. Universality of fractal aggregates as probed by light scattering. Proc. R. Soc. Lond. A. 423:71-87.
20. Ball, R. C., D. A. Weitz, T. A. Witten, and F. Leyvraz. 1987. Universal kinetics in reaction-limited aggregation. Phys. Rev. Lett. 58:274-277.
21. Broide, M. L., and R. J. Cohen. 1990. Experimental evidence of dynamic scaling in colloidal aggregation. Phys. Rev. Lett. 64:2026-2029.
22. Kerker, M. 1969. The Scattering of Light and Other Electromagnetic Radiation. Academic Press, New York.
23. Chen, S. H., and J. Texteira. 1986. Structure and fractal dimension of protein-detergent complexes. Phys. Rev. Lett. 57:2583-2586.
24. Berne, B. J., and R. Pecora. 1976. Dynamic Light Scattering. J. Wiley & Son, New York.
25. Provencher, S. 1982. Contin: a general purpose constrained regularization program for inverting noisy linear algebric and integral equations. Comput. Phys. Commun. 27:213-227.
26. Provencher, S. 1982. A constrained regularization method for inverting data represented by linear algebraic or integral equations. Comput. Phys. Commun. 27:229-242.
27. Maulucci, G., M. De Spirito, G. Arcovito, F. Boffi, T. Congiu Castellano, and G. Briganti. 2005. Particle size distribution in DMPC vesicles solutions undergoing different sonication time. Biophys. J. 88:3545-3550.
28. Berliner, J. A., M. C. Territo, A. Sevanian, S. Ramin, J. A. Kim, B. Bamshad, M. Esterson, and A. M. Fogelman. 1990. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J. Clin. Invest. 85:1260-1266.
29. Lin, M. Y., H. M. Lindsay, D. A. Weitz, R. C. Ball, R. Klein, and P. Meakin. 1990. Universal reaction-limited colloid aggregation. Phys. Rev. A. 41:2005-2020.
30. Brunelli, R., G. Mei, E. K. Krasnowska, F. Pierucci, L. Zichella, F. Ursini, and T. Parasassi. 2000. Estradiol enhances the resistance of LDL to oxidation by stabilizing apoB-100 conformation. Biochemistry. 39:13897-13903.
31. Pentikäinen, M. O., E. M. P. Lehtonen, and P. T. Kovanen. 1996. Aggregation and fusion of modified low density lipoprotein. J. Lipid Res. 37:2638-2649.
32. Öörni, K., M. Sneck, D. Brömme, M. O. Pentikäinen, K. A. Lindstedt, M. Mäyränpää, H. Aitio, and P. T. Kovanen. 2004. Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. J. Biol. Chem. 279:34776-34784.
33. Hakala, J. K., K. Öörni, M. Ala-Korpela, and P. T. Kovanen. 1999. Lipolytic modification of LDL by phospholipase A2 induces particle aggregation in the absence and fusion in the presence of heparin. Arterioscler. Thromb. Vasc. Biol. 19:1276-1283.
34. Hevonoja, T., M. O. Pentikäinen, M. T. Hyvönen, P. T. Kovanen, and M. Ala-Korpela. 2000. Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. Biochim. Biophys. Acta. 1488:189-210.
35. Brunelli, R., G. Greco, M. Barteri, E. K. Krasnowska, G. Mei, F. Natella, A. Pala, S. Rotella, F. Ursini, L. Zichella, and T. Parasassi. 2003. One site on the apoB-100 specifically binds 17-beta-estradiol and regulates the overall structure of LDL. FASEB J. 17:2127-2129.
36. Stefani, M., and C. M. Dobson. 2003. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J. Mol. Med. 81:678-699.