Human cancer xenograft perfusion in situ in rats: A new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agents

Journal of the American Association for Laboratory Animal Science

Volumn 45, Issue 3, 2006, Pages 38-44

  Dauchy, Erin M ^a   Dauchy, Robert T ^a   Davidson, Leslie K ^a   Lynch, Darin T ^a   Krause, Jean A ^a   Blue, Lia M ^a   Sauer, Leonard A ^a   Blask, David E ^a  

^a BASSETT RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FATTY ACID; GROWTH INHIBITOR; HYDROXY FATTY ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; MELATONIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGENIC AGENT; NEUROHORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PH; ARTICLE; ARTIFICIAL LUNG; BREAST TUMOR; CARBON DIOXIDE TENSION; CATHETER; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG INHIBITION; DRUG UPTAKE; FEMALE; GAS ANALYSIS; HUMAN; MALE; NONHUMAN; OXYGEN TENSION; PERFUSION; RAT; TUMOR GROWTH; TUMOR XENOGRAFT; VENOUS BLOOD;

ANALGESICS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; EICOSAPENTAENOIC ACID; FEMALE; HUMANS; LINOLEIC ACIDS, CONJUGATED; MELATONIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEOPLASM TRANSPLANTATION; PERFUSION; RATS; RATS, NUDE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

RODENTIA;

EID: 33744828692     PISSN: 15596109     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. q/11. J Biol Chem 269:12733-13735.
2. Berger M, Haag LA, Goodman M, Ruderman NB. 1976. Glucose metabolism in perfused skeletal muscle. Biochem J 158:191-202.
3. Blask DE, Brainard GC, Dauchy RT, Hannifan JP, Davidson LK, Krause JA, Sauer LA, Rivera-Bermudez MA, Dubocovich ML, Jasser SA, Lynch DT, Rollag MD, Zalatan F. 2005. Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res 65(23):11174-11184.
4. Blask DE, Dauchy RT, Sauer LA, Holowachuk EW, Ruhoff MS, Kopff HS. 1999. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism receptor-mediated signal transduction events. Cancer Res 59:4693-4701.
5. Blask DE, Dauchy RT, Sauer LA, Krause JA, Brainard GC. 2003. Growth and fatty acid metabolism of human breast cancer (MCF-T) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression. Breast Cancer Res Treat 79:313-320.
6. Blask DE, Sauer LA, Dauchy RT. 2002. Melatonin as a chronobiotic/ anticancer agent: cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem 2:113-132.
7. Bradford MM. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdoch PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Muir WS. 2003. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278:11303-11311.
9. Dauchy RT, Blask DE, Sauer LA. 2003. A new surgical technique for perfusion of the epididymal fat pad in situ in rats. Contemp Top Lab Anim Sci 42(3):39-43.
10. Dauchy RT, Blask DE, Sauer LA, Davidson LK, Krause JA, Smith LC, Dauchy EM. 2003. Physiologic melatonin concentration, omega-3 fatty acids, and conjugated linoleic acid inhibit fatty acid transport in rodent hind limb skeletal muscle in vivo. Comp Med 53:186-190.
11. Dauchy RT, Dauchy EM, Sauer LA, Blask DE, Davidson LK, Krause JA, Lynch DT. 2004. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. Cancer Lett 209:7-15.
12. Dauchy RT, Sauer LA. 1986. Preparation of "tissue-isolated" rat tumors for perfusion: a new surgical technique that preserves continuous blood flow. Lab Anim Sci 36:678-681.
13. Folch JM, Lees M, Sloane-Stanley GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-507.
14. Glantz SA. 1992. Primer of biostatistics. 3rd ed. New York: McGraw-Hill.
15. Glasgow WC, Hui R, Everhart AL, Jayawickreme SP, Angerman-Stewart J, Han B-B, Eling TE. 1997. The linoleic acid metabolite, (13-S)- hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes. J Biol Chem 272:19269-19276.
16. Gullino PM. 1961. Technique for growing in vivo "host-isolated" tumors. Fed Proc 20:153.
17. Gullino PM. 1968. In vitro perfusion of tumors. In: Norman JC, editor. Organ perfusion and preservation. New York: Appleton-Century-Croft. p 877-898.
18. Gullino PM, Grantham FH, Courtney AH, Losonczy I. 1967. Relationship between oxygen and glucose consumption by transplanted tumors in vivo. Cancer Res 27:1041-1052.
19. Hardy S, St Onge GG, Joly E, Langelier Y, Prentki M. 2005. Oleate promotes the proliferation of breast cancer cells via the G-protein-coupled receptor GPR40. J Biol Chem 280:13285-13291.
20. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M, Tanaka, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shinohara T, Hinuma S, Fujisawa Y, Fujino M. 2003. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR 40. Nature (London) 422:173-176.
21. Katsuma S, Hatae N, Yano T, Yoshinao R, Kimura M, Hirasawa A, Tsujimoto G. 2005. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in murine enteroendocrine cell line STC-1. J Biol Chem 280:19507-19515.
22. Kotarsky K, Nilsson NE, Flodgren E, Owman C, Olde B. 2003. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301:406-410.
23. Kowalski TJ, Wu G, Watford M. 1997. Rat adipose tissue amino acid metabolism in vivo as assessed by microdialysis and arteriovenous techniques. Am J Physiol 273(3 Pt 1):E613-E622.
24. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
25. McDonald-Gibson RG. 1987. Quantitative measurements of arachidonic acid in tissues or fluids. In: Benedetto C, McDonald-Gibson RG, Nigram S, Slater F, editors. Prostaglandins and related substances. Washington (DC): IRL Press, p 259-268.
26. National Research Council. 1996. Guide for care and use of laboratory animals. National Academy Press, Washington, D.C.
27. Ross BD. 1972. Perfusion techniques in biochemistry. London: Clarendon Press-Oxford, p 8-99.
28. Ruderman NB, Houghton CRS, Hems R. 1971. Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 124:639-651.
29. 3H] thymidine incorporation in hepatoma 7288CTC perfused in situ. Cancer Res 48:3106-3111.
30. 3H-thymidine incorporation in hepatoma 7288CTC perfused in situ. Br J Cancer 66:297-303.
31. Sauer LA, Dauchy RT, Blask DE. 2000. Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. Cancer Res 60:5289-5295.
32. Sauer LA, Dauchy RT, Blask DE, Krause JA, Davidson LK, Dauchy EM. 2005. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. J Nutr 135:2124-2129.
33. Sauer LA, Dauchy RT, Blask DE, Krause JA, Davidson LK, Dauchy EM, Welham KJ, Coupland K. 2004. Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats. J Nutr 134:1989-1997.
34. Sauer LA, Stayman JW III, Dauchy RT. 1982. Amino acid, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res 42:4090-4097.
35. Yonezawa T, Katoh K, Obara Y. 2004. Existence of GRP40 functioning in a human breast cancer cell line, MCF-7. Biochem Biophys Res Commun 314:805-309.